Effects of dietary carbohydrate on the incidence of mammary tumors induced in rats by 7, 12‐dimethylbenz[α] anthracene

Hoehn, Susan K.; Carroll, K. K.

doi:10.1080/01635587909513625

Cited by 19 publications

(3 citation statements)

References 10 publications

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“…Studies in rats have found an increased incidence of 7,12-dimethylbenz(a)anthracene-induced breast cancer in animals fed diets high in vegetable fat [ 14] and sugar [15]. There are several points in the current study that are of particular interest.…”

confidence: 73%

Trends in diet and breast cancer mortality in England and Wales 1928–1977

1981

Nutrition and Cancer

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Trends in age-adjusted breast cancer mortality and consumption of meat, fat, sugar, cereal, and fruit and vegetables were studied for England and Wales over the 50-year period from 1928 to 1977. At the onset of World War II, there was a marked reduction in both breast cancer mortality and intake of sugar, meat and fat, and an increased consumption of cereals and vegetables. Consumption of these foodstuffs returned to pre-war levels by 1954, but breast cancer mortality did not return to pre-war levels until some 15 years later. The association between the various dietary components and subsequent breast cancer mortality was determined for various lag intervals. Significant correlations were found for cereal, fat, sugar and meat consumption, the correlation being maximal for a diet-breast cancer death lag interval of 12 years. These findings add weight to the hypothesis that breast cancer development is related to a diet rich in meat, fat and sugar, and that some protection against cancer may be afforded by a reduction in these dietary components and an increase in cereal consumption.

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confidence: 73%

Trends in diet and breast cancer mortality in England and Wales 1928–1977

1981

Nutrition and Cancer

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“…In 1979, Hoehn et al demonstrated that after injection of 7,12-dimethylbenz(α)-anthracene (DMBA), rats that consumed sucrose/dextrose diets developed more mammary tumors than rats fed with starch (6). However using the same rat model, Klurfeld and colleagues observed opposite results that consumption of a corn starch diet was associated with the most palpable and largest tumors than rats fed with sucrose or lactose diets (7).…”

Section: Introductionmentioning

confidence: 99%

A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway

et al. 2016

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Epidemiological studies have shown that dietary sugar intake has a significant impact on the development of breast cancer. One proposed mechanism for how sugar impacts cancer development involves inflammation. In the current study, we investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models, along with mechanisms that may be involved. We found that sucrose intake in mice comparable to levels of Western diets led to increased tumor growth and metastasis, when compared to a non-sugar starch diet. This effect was ascribed in part to increased expression of 12-lipoxygenase 12-LOX) and its arachidonate metabolite 12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid 12-HETE). We determined that fructose derived from the sucrose was responsible for facilitating lung metastasis and 12-HETE production in breast tumors. Overall, our data suggested that dietary sugar induces 12-LOX signaling to increase risks of breast cancer development and metastasis.

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“…This was observed at both high and low levels of dietary fat. 23 Like the epidemiological data, however, the results of experiments with animals Indicated that dietary carbohydrate had less influence on mammary carcinogenesis than did dietary fat.…”

Section: Effects Of Dietary Components Other Than Fat On Mammary Carcmentioning

confidence: 86%

Diet and carcinogenesis

Carroll

1981

Nutrition and Cancer

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Analysis of epidemiological data and experiments with animals have provided evidence that dietary fat has an important influence on mammary cancer. Further epidemiological studies should be carried out to examine this relationship more fully, and additional experimental work is required to determine the mechanisms by which dietary fat influences mammary cancer in animals. Dietary carbohydrate and minor dietary components, such as retinoids and certain trace elements, have also been shown to influence mammary cancer in animals. Decreasing the fat content of the diet may offer a practical means of reducing mortality from breast cancer, which continues to be a major cause of death in many parts of the world.

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Effects of dietary carbohydrate on the incidence of mammary tumors induced in rats by 7, 12‐dimethylbenz[α] anthracene

Cited by 19 publications

References 10 publications

Trends in diet and breast cancer mortality in England and Wales 1928–1977

Trends in diet and breast cancer mortality in England and Wales 1928–1977

A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway

Diet and carcinogenesis

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