Effects of dietary calcium pyruvate on gastrointestinal tract development, intestinal health and growth performance of newly weaned piglets fed low‐protein diets

Wan, Ke; Li, Yunxia; Sun, Weizhong; An, Rui; Tang, Zhiru; Wu, Liuting; Chen, Huiyuan

doi:10.1111/jam.14494

Cited by 16 publications

(11 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Researchers also showed that weaned pigs fed low CP diets (16% instead of 20% CP) can reduce up to 30% the daily treatments for diarrheic symptoms in the 6-15 kg phase [145]. Furthermore, a low CP diet (15.5% instead of 20% CP) helps in lowering IL-1, TNF-α, IL-2, IL-6 and increasing IL-10 and IL-13 concentrations in the colonic mucosa of weanling piglets, probably due to a reduction of the inflammation elicited by the ingestion of antinutritional factors and feed antigens usually occurring with common protein sources such as soybean meal [146].…”

Section: Adjusting Diet Composition: Protein and Fibermentioning

confidence: 99%

“…However, pig performance typically declines when dietary CP percent is heavily reduced, so lower productivity should be taken into account when opting for this alternative strategy to phase out medicinal levels of ZnO [144]. Even if later additions of dietary high CP can counterbalance for the initial lower performance [145], some compensatory strategies are currently under investigation, such as management precautions and supplementation of both essential and branched-chain AA [146][147][148]. Overall, these insights show that dietary CP plays a role in the PWD onset and that its concentration should be carefully determined to avoid an easier E. coli F4 gut colonization at weaning.…”

Section: Adjusting Diet Composition: Protein and Fibermentioning

confidence: 99%

See 1 more Smart Citation

Towards Zero Zinc Oxide: Feeding Strategies to Manage Post-Weaning Diarrhea in Piglets

Bonetti

Tugnoli²,

Piva

et al. 2021

Animals

107

View full text Add to dashboard Cite

Zinc oxide (ZnO) at pharmacological doses is extensively employed in the pig industry as an effective tool to manage post-weaning diarrhea (PWD), a condition that causes huge economic losses because of its impact on the most pivotal phase of a piglet’s production cycle. In a multifactorial way, ZnO exerts a variety of positive effects along the entire gastrointestinal tract by targeting intestinal architecture, digestive secretions, antioxidant systems, and immune cells. ZnO also has a moderate antibacterial effect against Escherichia coli F4 (K88), the main causative agent of PWD. However, the environmental impact of ZnO and new emerging threats are posing serious questions to the sustainability of its extensive utilization. To work towards a future free from pharmacological ZnO, novel nutritional approaches are necessary, and many strategies have been investigated. This review article provides a comprehensive framework for ZnO utilization and its broad mode of action. Moreover, all the risks related to pharmacological ZnO levels are presented; we focus on European institutions’ decisions subsequently. The identification of a novel, complete solution against PWD should be accompanied by the adoption of holistic strategies, thereby combining good management practices to feeding approaches capable of mitigating Escherichia coli F4 (K88) infections and/or lowering ZnO utilization. Promising results can be obtained by adjusting diet composition or employing organic acids, natural identical compounds, polyphenol-rich extracts, prebiotics, and probiotics.

show abstract

Section: Adjusting Diet Composition: Protein and Fibermentioning

confidence: 99%

Section: Adjusting Diet Composition: Protein and Fibermentioning

confidence: 99%

Towards Zero Zinc Oxide: Feeding Strategies to Manage Post-Weaning Diarrhea in Piglets

Bonetti

Tugnoli²,

Piva

et al. 2021

Animals

107

View full text Add to dashboard Cite

show abstract

“…(2018) found that dietary lysine restriction enhanced the relative abundances of Escherichia-Shigella , Aquabacterium , and Candidatus Methylomirabilis in the ileum of piglets at the genus level, while reducing the abundance of Streptococcus , Bacteroides , Bacillus , Pasteurella , Clostridium sensu stricto , Faecalibacterium , Paucisalibacillus , and Lachnoclostridium . A low-protein diet decreased the relative richness of Firmicutes in the colon contents of weaned piglets at the phylum level, yet increased the relative richness of Proteobacteria ( Wan et al., 2020 ). In a study by Raza et al.…”

Section: Effects Of Dietary Protein/amino Acid Metabolism On Intestinal Microorganismsmentioning

confidence: 99%

Mutual interaction between gut microbiota and protein/amino acid metabolism for host mucosal immunity and health

Tang

Chen

et al. 2021

Animal Nutrition

Self Cite

View full text Add to dashboard Cite

In recent years, many studies have shown that the intestinal microflora has various effects that are linked to the critical physiological functions and pathological systems of the host. The intestinal microbial community is widely involved in the metabolism of food components such as protein, which is one of the essential nutrients in diets. Additionally, dietary protein/amino acids have been shown to have had a profound impact on profile and operation of gut microbiota. This review summarizes the current literature on the mutual interaction between intestinal microbiota and protein/amino acid metabolism for host mucosal immunity and health.

show abstract

“…After the duodenum, jejunum, and ileum were rinsed with normal saline (0.9% NaCl), the intestinal mucosa from a 6 cm middle area was scraped off using a slide and snap-frozen in liquid nitrogen, and a 2 cm middle tissue sample was rinsed and then snap frozen in liquid nitrogen. The colonic chyme was snap-frozen in liquid nitrogen and stored at −80°C for further analysis (Wan et al, 2020).…”

Section: Sample Collectionmentioning

confidence: 99%

Organic Selenium Increased Gilts Antioxidant Capacity, Immune Function, and Changed Intestinal Microbiota

Dong

Chen

et al. 2021

Front. Microbiol.

View full text Add to dashboard Cite

Selenium is an indispensable essential micronutrient for humans and animals, and it can affect biological functions by combining into selenoproteins. The purpose of this study was to investigate the effects of 2-hydroxy-4-methylselenobutanoic acid (HMSeBA) on the antioxidant performance, immune function, and intestinal microbiota composition of gilts. From weaning to the 19th day after the second estrus, 36 gilts (Duroc × Landrace × Yorkshire) were assigned to three treatments: control group, sodium selenite group (0.3 mg Se/kg Na2SeO3), and HMSeBA group (0.3 mg Se/kg HMSeBA). Dietary supplementation with HMSeBA improved the gilts tissue selenium content (except in the thymus) and selenoprotein P (SelP1) concentration when compared to the Na2SeO3 or control group. Compared with the control group, the antioxidant enzyme activity in the tissues from gilts in the HMSeBA group was increased, and the concentration of malondialdehyde in the colon had a decreasing trend (p = 0.07). Gilts in the HMSeBA supplemented group had upregulated gene expression of GPX2, GPX4, and SelX in spleen tissue, TrxR1 in thymus; GPX1 and SelX in duodenum, GPX3 and SEPHS2 in jejunum, and GPX1 in the ileum tissues (p < 0.05). In addition, compared with the control group, the expression of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemotactic protein-1 (MCP-1) in the liver, spleen, thymus, duodenum, ileum, and jejunum of gilts in the HMSeBA group were downregulated (p < 0.05), while the expression of interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) in the liver, thymus, jejunum, and ileum were upregulated (p < 0.05). Compared with the control group and the Na2SeO3 group, HMSeBA had increased concentration of serum cytokines interleukin-2 (IL-2) and immunoglobulin G (IgG; p < 0.05), increased concentration of intestinal immunoglobulin A (sIgA; p < 0.05), and decreased concentration of serum IL-6 (p < 0.05). Dietary supplementation with HMSeBA also increased the abundance of intestinal bacteria (Ruminococcaceae and Phascolarctobacterium; p < 0.05) and selectively inhibited the abundance of some bacteria (Parabacteroides and Prevotellaceae; p < 0.05). In short, HMSeBA improves the antioxidant performance and immune function of gilts, and changed the structure of the intestinal microflora. And this study provided data support for the application of HMSeBA in gilt and even pig production.

show abstract

Effects of dietary calcium pyruvate on gastrointestinal tract development, intestinal health and growth performance of newly weaned piglets fed low‐protein diets

Cited by 16 publications

References 44 publications

Towards Zero Zinc Oxide: Feeding Strategies to Manage Post-Weaning Diarrhea in Piglets

Towards Zero Zinc Oxide: Feeding Strategies to Manage Post-Weaning Diarrhea in Piglets

Mutual interaction between gut microbiota and protein/amino acid metabolism for host mucosal immunity and health

Organic Selenium Increased Gilts Antioxidant Capacity, Immune Function, and Changed Intestinal Microbiota

Contact Info

Product

Resources

About