Effects of dietary allicin on health and growth performance of weanling piglets and reduction in attractiveness of faeces to flies

Huang, Ruihua; Qiu, Xuan; Shi, Feng; Hughes, Claude L.; Lu, Zhifeng; Zhu, Weiwen

doi:10.1017/s1751731110001953

Cited by 15 publications

(9 citation statements)

References 22 publications

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“…However, Yan & Kim (2013) demonstrated that with 0.05% fermented garlic powder administration, ADG but not DM digestibility increased in weaning piglets. Huang et al (2011) showed that allicin supplementation may improve growth performance, decrease diarrhea incidence and fly attractiveness of the faces of weanling piglets, perhaps indicating reduced dissemination of pathogens. A recent study conducted by Yun, Nyachoti & Kim (2018) found that diets supplemented with fermented garlic by Leuconostoc mesenteroides KCCM35046 (0.1% and 0.2%) inhibited body weight losses of lactating sows and promoted the ADG of suckling piglets in lactation period.…”

Section: Nutritional Applications In Animalsmentioning

confidence: 99%

The nutritional applications of garlic (Allium sativum) as natural feed additives in animals

Chen¹,

Wang²,

Yin³

et al. 2021

PeerJ

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Garlic (Allium sativum) is an essential vegetable that has been widely utilized as seasoning, flavoring, culinary and in herbal remedies. Garlic contains several characteristic organosulfur compounds, such as diallyl sulfide, allicin (diallyl thiosulphate), γ-glutamylcysteine, and S-allyl cysteine (alliin) and ajoene, which garlic has beneficial effects on inflammation, oxidative stress markers, hypertension, hyperlipidaemia and endothelial function in vitro or in animal model. These bioactive molecules are also playing pivotal role in livestock and fisheries production apart from its application in humans. Supplementation of animal feed with garlic and its related products is consistent with the modern agricultural concept of organic animal husbandry. This review compiles the information describing the effects of feeding garlic and its extracts on selected performance parameters in animals (chicken, rabbits, ruminants, pigs and fish). This review may provide reference for scientists and entrepreneurs to investigate the applications of feeds added with garlic and allicin by-products for the improvement of animal husbandry and aquatic production.

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Section: Nutritional Applications In Animalsmentioning

confidence: 99%

The nutritional applications of garlic (Allium sativum) as natural feed additives in animals

Chen¹,

Wang²,

Yin³

et al. 2021

PeerJ

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“…The active compounds in garlic that seem to have beneficial effects are sulphide breakdown products such as alliin, diallylsulphides, and allicin [ 34 ]. Several studies have shown that dietary supplementation of garlic appears to improve the immune response and growth performance of growing pigs [ 39 , 40 , 41 ]. Horn et al [ 42 ] observed that this plant could partially mitigate the stress effects of the postweaning period, producing a positive effect on growth performance, intestinal function, and antioxidant status.…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Supplementation of Garlic and Oregano Essential Oil on Biomarkers of Oxidative Status, Stress and Inflammation in Postweaning Piglets

Rivera-Gomis

Rubio

Conesa³

et al. 2020

Animals

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The effects of two different concentrations of micro capsuled oregano essential oil (OEO) and purple garlic powder on biomarkers of oxidative status, stress, and inflammation, as well as on average daily gain (ADG) and feed conversion ratio (FCR), were evaluated in piglets during the postweaning period. The trial was carried out with 300 crossbred pigs of 21 days of age fed with different concentrations of OEO and purple garlic powder and ZnO. Saliva and serum samples were taken to evaluate a panel of biomarkers of oxidative status, stress, and inflammation. OEO and garlic powder at 0.4% did not produce significant changes in C-reactive protein (CRP) and cortisol and yielded higher levels of the antioxidant biomarker CUPRAC in serum than higher doses (p < 0.01); they yielded a better ADG than the control and ZnO diets. OEO and garlic powder at higher concentrations than 0.4% showed higher concentrations of CRP (p < 0.05). Overall, doses of OEO and garlic powder at 0.4% did not lead to inflammation, stress, or negative changes in oxidative biomarkers in piglets during the postweaning period and gave better productive performance than the control and ZnO diets. High doses of OEO and garlic powder were ineffective and could negatively affect the animals. Therefore, our results highlight the importance of the dose used when OEO or garlic are supplemented to piglets.

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“…Early weaning is a stressful event triggering both the occurrence of oxidative stress and the changes of gut microbiota, resulting in gut damage and disease susceptibility in infants and young animals (Huang et al, 2010;Kim et al, 2012). The N-acetyl cysteine (NAC) plays a pivotal role in protection of cells against reactive oxygen species (ROS)-induced damages (Dodd et al, 2008), direct modulation of the activity of redox-sensitive transcription factor (Atis et al, 2006), and effective prevention of bacterial translocation and oxidative stress (Ocal et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Regulation of N-acetyl cysteine on gut redox status and major microbiota in weaned piglets1

Yang

Zhu

et al. 2014

Journal of Animal Science

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This study was conducted to explore the regulation of N-acetyl cysteine (NAC) on gut redox status and proliferation of selected microbiota in weaned piglets. A total of 150 newborn piglets from 15 litters were randomly divided by litter to the control group (normally suckling), the weaning group (fed the basal diet), and the NAC group (basal + NAC diet) with 5 litters per group. Activities of total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and inhibition capacity of hydroxyl radical (IHR), and contents of malondialdehyde (MDA), H2O2, and NO in the ileum, colon, and cecum were analyzed to profile oxidative stress states. The real-time absolute quantitative PCR reaction was employed to quantify the amounts of total bacteria, Lactobacillus, Bifidobacterium, and Escherichia coli. The N-acetyl cysteine, as a universal antioxidant, was used to improve the redox status. Results showed that weaning stress resulted in the occurrence of gut oxidative stress and changes of gut microbiota (P < 0.05). Compared with the weaned piglets, the activities of ileal, colonic, and cecal T-AOC; ileal and colonic GSH-Px; cecal SOD; and colonic and cecal IHR were enhanced (P < 0.05), and the concentrations of ileal and cecal H2O2, ileal and colonic NO, and colonic MDA were reduced (P < 0.05) in the NAC-treated piglets. An increase (P < 0.05) in gut Lactobacillus and Bifidobacterium, accompanied with a decrease (P < 0.05) in Escherichia coli counts, was also observed in the NAC group. Bivariate correlation indicated that Lactobacillus and Bifidobacterium were positively correlated (P < 0.05) with the activities of T-AOC, GSH-Px, and SOD and inversely related (P < 0.05) to increased levels of H2O2, NO, OH, and MDA, and Escherichia coli showed a strong positive association (P < 0.05) with increased levels of free radicals and MDA and a negative association (P < 0.05) with the activities of antioxidant enzymes in intestines of weaned piglets. We concluded that NAC constructively regulated on the changes of the gut redox status and microbiota in piglets in response to weaning stress. The observed correlations implied that the NAC effects on the gut microbiota were confirmed, partly through an effect on oxidative stress in piglets, providing evidence that gut microbiota may be potentially improved by the modulation of the redox status by an antioxidant, which has relevance for gut health and function.

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Effects of dietary allicin on health and growth performance of weanling piglets and reduction in attractiveness of faeces to flies

Cited by 15 publications

References 22 publications

The nutritional applications of garlic (Allium sativum) as natural feed additives in animals

The nutritional applications of garlic (Allium sativum) as natural feed additives in animals

Effects of Dietary Supplementation of Garlic and Oregano Essential Oil on Biomarkers of Oxidative Status, Stress and Inflammation in Postweaning Piglets

Regulation of N-acetyl cysteine on gut redox status and major microbiota in weaned piglets1

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