Effects of dietary 5-aminolevulinic acid on growth performance and nonspecific immunity of Litopenaeus vannamei, as determined by transcriptomic analysis

Ye, Yucong; Li, Siwen; Du, Xinglin; Zhang, Lin; Bao, Ning; Li, Yiming; Zhao, Yunlong

doi:10.1016/j.fsi.2024.109746

Fish & Shellfish Immunology

2024

DOI: 10.1016/j.fsi.2024.109746

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Effects of dietary 5-aminolevulinic acid on growth performance and nonspecific immunity of Litopenaeus vannamei, as determined by transcriptomic analysis

Yucong Ye,

Siwen Li,

Xinglin Du

et al.

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Multi-Omics Integrative Analysis to Reveal the Impacts of Shewanella algae on the Development and Lifespan of Marine Nematode Litoditis marina

Xue,

Zhang

2024

IJMS

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Understanding how habitat bacteria affect animal development, reproduction, and aging is essential for deciphering animal biology. Our recent study showed that Shewanella algae impaired Litoditis marina development and lifespan, compared with Escherichia coli OP50 feeding; however, the underlying mechanisms remain unclear. Here, multi-omics approaches, including the transcriptome of both L. marina and bacteria, as well as the comparative bacterial metabolome, were utilized to investigate how bacterial food affects animal fitness and physiology. We found that genes related to iron ion binding and oxidoreductase activity pathways, such as agmo-1, cdo-1, haao-1, and tdo-2, were significantly upregulated in L. marina grown on S. algae, while extracellular structural components-related genes were significantly downregulated. Next, we observed that bacterial genes belonging to amino acid metabolism and ubiquinol-8 biosynthesis were repressed, while virulence genes were significantly elevated in S. algae. Furthermore, metabolomic analysis revealed that several toxic metabolites, such as puromycin, were enriched in S. algae, while many nucleotides were significantly enriched in OP50. Moreover, we found that the “two-component system” was enriched in S. algae, whereas “purine metabolism” and “one-carbon pool by folate” were significantly enriched in E. coli OP50. Collectively, our data provide new insights to decipher how diet modulates animal fitness and biology.

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Multi-Omics Integrative Analysis to Reveal the Impacts of Shewanella algae on the Development and Lifespan of Marine Nematode Litoditis marina

Xue,

Zhang

2024

IJMS

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Effects of dietary 5-aminolevulinic acid on growth performance and nonspecific immunity of Litopenaeus vannamei, as determined by transcriptomic analysis

Cited by 1 publication

References 71 publications

Multi-Omics Integrative Analysis to Reveal the Impacts of Shewanella algae on the Development and Lifespan of Marine Nematode Litoditis marina

Multi-Omics Integrative Analysis to Reveal the Impacts of Shewanella algae on the Development and Lifespan of Marine Nematode Litoditis marina

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