Effects of diet supplementation with Camu-camu (Myrciaria dubia HBK McVaugh) fruit in a rat model of diet-induced obesity

Nascimento, Ozanildo Vilaça do; Boleti, Ana Paula de Araújo; Yuyama, Lúcia Kiyoko Ozaki; Lima, Emerson Silva

doi:10.1590/s0001-37652013005000001

Cited by 52 publications

(38 citation statements)

References 23 publications

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“…In the present study, we demonstrated that the pulp of Camu-camu reduced body weight and epididymal and visceral fat, such as reduced fat deposited in the face, heart and liver, in addition to decrease the inflammatory proteins [16]. Several experimental studies have shown that exercise combined with continued dieting results in reduced adiposity, lipid profile and reduction of biochemical parameters in rats [17][18][19].…”

Section: Introductionsupporting

confidence: 59%

“…Researchers report results of biological assays on the action of Camu-camu (Myrciaria dubia H.B.K. McVaugh) on the reduction of lipid profile and lipid peroxidation, on triglyceride levels with decreased hypercholesterolemia in obese and diabetic rats [16,33,34] cholesterol reduction total cholesterol, LDL-c, triglycerides and modifications in the metabolic profile of adults with metabolic syndrome [35,36].…”

Section: Discussionmentioning

confidence: 99%

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Dietary supplementation with camu-camu and continuous exercises in the treatment of obesity

et al. 2018

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Objective The goal of this study were to investigate the effects of continuous exercise with/or without the ingestion the Camu-camu pulp in a rat model of obesity. Methods Neonate male Wistar rats, receiving monosodium glutamate, subcutaneously were separated into foour groups: sedentary group S (no treatment), exercise group E (continuous swimming training), Camu-camu group C (25mL of pulp of Camu-camu/day) and exercise and Camu-camu group EC (25mL of pulp of Camu-camu/day, continuous swimming). After 12 weeks, the animals were received euthanasia. Results The exercise program was conducted for five days for 12 weeks and the effects of supplementation with or without Camu-camu in obese rats were analyzed, showing that the relative levels of the variables cholesterol, triglycerides, glucose, High Density Lipoprotein and Low Density Lipoprotein and in all groups there was a significant reduction (.<0.001), except for the control group. Body weight and feed intake, epididymal and visceral fat deposits were not significantly different between the means of groups C and E, but these groups showed a significant difference when compared to the EC group (.<0.001). Conclusion The results demonstrate the effectiveness of continuous exercise and diet supplemented with Camu-camu fruit pulp to control obesity.

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Section: Introductionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Dietary supplementation with camu-camu and continuous exercises in the treatment of obesity

et al. 2018

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“…Respecto de la grasa corporal, los tejidos adiposos retroperitoneal, epididimal y visceral (mesentérica, perineal, omental) se removieron y pesaron en báscula analítica, y posteriormente se sumaron, revelando el valor total de grasa corporal de cada animal 14 . Además, se computaron el índice de adiposidad (IA) y grasa hepática conforme al método de Folch et al 15 .…”

Section: Diseño Experimental Y Dietasunclassified

El consumo de la polidextrosa previene la obesidad y sus comorbilidades en ratas alimentados con dieta hipercalórica

Souza

Zampieri

et al. 2020

Rev. chil. nutr.

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RESUMEN El objetivo de este trabajo fue evaluar el efecto de las diferentes concentraciones de polidextrosa en la prevención de la obesidad y sus comorbilidades, en ratas alimentados con dieta hipercalórica. Se utilizaron ratas machos Wistar, repartidos en 4 grupos: Grupo control (HC) y 3 grupos que recibieron dieta hipercalórica con suplementación del 2%, 4% y 6% de polidextrosa (HC2%P, HC4%P y HC6%P respectivamente). La dieta hipercalórica utilizada fue la del tipo de cafetería para inducir la obesidad. Se midió peso corporal e ingesta de la dieta, se realizaron pruebas de tolerancia a la glucosa y a la insulina. Los animales fueron sometidos a eutanasia para toma de muestra de sangre medidas antropométricas y pesaje de órganos y tejidos. La polidextrosa disminuyó significantemente el peso, la grasa corporal, la glicemia, los triglicéridos, la intolerancia a la glucosa y la resistencia a la insulina, y aumentó los niveles del colesterol HDL. Se concluye que el consumo de polidextrosa redujo las complicaciones derivadas de la obesidad en ratas alimentados con dieta hipercalórica, siendo éste un potencial tratamiento para el control de la obesidad, la diabetes tipo II y las enfermedades cardiovasculares.

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“…Further, fecal cholesterol excretion was increased. In addition, assays performed by Nascimento et al [44] in a rat model of diet-induced obesity that ingested daily 25 mL of camu camu fruit pulp by 12 weeks resulted in a significant weights reduction of the fat in white adipose tissues. Triacylglycerols (↓40.6%), total cholesterol (↓39.6%), LDL cholesterol (↓2.14%), and VLDL cholesterol (↓36.4%) levels were also decreased, and HDL cholesterol (↑12.3%) increased in experimental groups.…”

Section: Antiobesity Hypolipidemic and Antihypertensive Activitiesmentioning

confidence: 99%

Myrciaria dubia “Camu Camu” Fruit: Health-Promoting Phytochemicals and Functional Genomic Characteristics

Gómez¹,

Maddox²,

Cobos³

et al. 2018

Breeding and Health Benefits of Fruit and Nut Crops

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Camu camu is a typical Amazon native fruit shrub that possesses a diploid genome, moderate genetic diversity, and population structure. The fruits accumulate several essential nutrients and synthesize L-ascorbic acid (vitamin C) in great quantities and an array of diverse secondary metabolites with corroborated in vitro and in vivo health-promoting activities. These beneficial effects include antioxidative and antiinflammatory activities, antiobesity, hypolipidemic, antihypertensive and antidiabetic effects, DNA damage and cancer protection effects, and other bioactivities. Many health-promoting phytochemicals are biosynthesized in several metabolic pathways of camu camu. Their reconstruction from the fruit transcriptome database was accomplished by our research group. These include basic metabolic pathways such as glycolysis and pentose phosphate pathway, vitamin C biosynthesis pathways, and pathways involved in secondary metabolites production. Due to their agronomic potential and fruits growing demand, recently, based on an ideotype, programs were initiated for their domestication and genetic improvement, but so far with very negligible achievements. Consequently, we propose new strategies to accelerate the processes of domestication and genetic improvement based on state of the art technologies for multiomic data analysis and innovative molecular tools.

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Effects of diet supplementation with Camu-camu (Myrciaria dubia HBK McVaugh) fruit in a rat model of diet-induced obesity

Cited by 52 publications

References 23 publications

Dietary supplementation with camu-camu and continuous exercises in the treatment of obesity

Dietary supplementation with camu-camu and continuous exercises in the treatment of obesity

El consumo de la polidextrosa previene la obesidad y sus comorbilidades en ratas alimentados con dieta hipercalórica

Myrciaria dubia “Camu Camu” Fruit: Health-Promoting Phytochemicals and Functional Genomic Characteristics

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