Effects of diet restriction on life span and age-related changes in dogs

Kealy, Richard D.; Lawler, Dennis F.; Ballam, J.M.; Mantz, Sandra L.; Biery, Darryl N.; Greeley, Elizabeth H.; Lust, George; Segre, Mariangela; Smith, Gail K.; Stowe, Howard D.

doi:10.2460/javma.2002.220.1315

Cited by 498 publications

(433 citation statements)

References 15 publications

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“…This damage is thought to remain latent for some time, but eventually results in an earlier onset of aging and degenerative disease as well as increased rates of certain cancers. This theory is supported by the finding that adult giant breed dog cells have a lower proliferative capacity than those of other breeds (45), that large dogs tend to develop nonhereditary cataracts (thought to be due to accumulated oxidative damage) at an earlier age than small dogs (75), as well as the finding that dogs fed an energetically restricted diet tend to live longer than dogs fed a regular diet (38,43).…”

Section: Reduced Lifespan In Giant Breedssupporting

confidence: 66%

Lifespan and disease predispositions in the Irish Wolfhound: A review

Urfer¹,

Gaillard²,

Steiger³

2007

Veterinary Quarterly

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Section: Reduced Lifespan In Giant Breedssupporting

confidence: 66%

Lifespan and disease predispositions in the Irish Wolfhound: A review

Urfer¹,

Gaillard²,

Steiger³

2007

Veterinary Quarterly

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“…Metabolic derangements also arise (14)(15)(16)(17) , and there are alterations in renal function (18) . All in all, obesity adversely affects quality of life (19) , and shortens lifespan (20) . Given these adverse effects on health and quality of life, canine obesity presents a major welfare challenge for veterinary surgeons.…”

Section: The Significance Of Obesity In Petsmentioning

confidence: 99%

Outcomes of weight management in obese pet dogs: what can we do better?

German

2016

Proc. Nutr. Soc.

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Obesity is arguably the biggest health and welfare issue affecting pet dogs. Although successful weight loss has health benefits, current strategies are far from ideal. Many obese dogs that start a weight programme fail to lose weight, or subsequently regain the weight they have lost. Given that current weight loss strategies are not perfect, clinicians need to focus carefully on tailoring the programme, perhaps setting a pragmatic target for weight loss, so as to ensure the benefits are maximised. This review will summarise key findings from recent clinical research into pet obesity, and present a framework for improving success, by better tailoring weight management regimens and end points to the individual.

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“…For example, dogs fed a regular diet demonstrated greater radiographic severity of OA in the elbow in comparison to CR dogs after 6 years of diet treatment, but at year 8 (end of life mark), OA severity of both groups was not statistically different (Huck et al 2009). Similarly, a study that examined dogs with and without diet intervention for an entire lifespan found that there was only a 9 % decrease in OA incidence in the CR group (Kealy et al 2002). These findings indicate that CR may delay the onset of symptoms or radiographic evidence of OA but may not ultimately prevent the development of OA (Kealy et al 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, a study that examined dogs with and without diet intervention for an entire lifespan found that there was only a 9 % decrease in OA incidence in the CR group (Kealy et al 2002). These findings indicate that CR may delay the onset of symptoms or radiographic evidence of OA but may not ultimately prevent the development of OA (Kealy et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Life-long caloric restriction does not alter the severity of age-related osteoarthritis

McNeill

Rabey

et al. 2014

AGE

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Chronic adipose tissue inflammation and its associated adipokines have been linked to the development of osteoarthritis (OA). It has been shown that caloric restriction may decrease body mass index and adiposity. The objectives of this study were to investigate the effect of lifelong caloric restriction on bone morphology, joint inflammation, and spontaneously occurring OA development in aged mice. C57BL/NIA mice were fed either a calorie-restricted (CR) or ad libitum (AL) diet starting at 14 weeks of age. All mice were sacrificed at 24 months of age. Adipose tissue and knee joints were then harvested. Bone parameters of the joints were analyzed by micro-CT. OA and joint synovitis were determined using histology and semiquantitative analysis. Lifelong caloric restriction did not alter the severity of OA development in C57BL/NIA aged mice, and there was no difference in the total joint Mankin score between CR and AL groups (p=0.99).Mice also exhibited similar levels of synovitis (p=0.54). The bone mineral density of the femur and the tibia was comparable between the groups with a small increase in cancellous bone volume fraction in the lateral femoral condyle of the CR group compared with the AL group. Lifelong caloric restriction did not alter the incidence of OA or joint synovitis in C57BL/NIA mice, indicating that a reduction of caloric intake alone was not sufficient to prevent spontaneous age-related OA. Nonetheless, early initiation of CR continued throughout a life span did not negatively impact bone structural properties.

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Effects of diet restriction on life span and age-related changes in dogs

Abstract: Results suggest that 25% restriction in food intake increased median life span and delayed the onset of signs of chronic disease in these dogs.

Cited by 498 publications

References 15 publications

Lifespan and disease predispositions in the Irish Wolfhound: A review

Lifespan and disease predispositions in the Irish Wolfhound: A review

Outcomes of weight management in obese pet dogs: what can we do better?

Life-long caloric restriction does not alter the severity of age-related osteoarthritis

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