Effects of diet-induced obesity and voluntary wheel running on the axial and peripheral skeleton microstructure in mice

Deletion of Rptor in Preosteoblasts Reveals a Role for the Mammalian Target of Rapamycin Complex 1 (mTORC1) Complex in Dietary‐Induced Changes to Bone Mass and Glucose Homeostasis in Female Mice

“…In response to HFD feeding, we observed little or no significant changes in both trabecular and cortical bone parameters in the control mice. This was consistent with some (43,55) but not other studies (49,50,(56)(57)(58)(59)(60) . Studies using C57BL/6J male mice fed with HFD from 4 to 23 weeks (56) , 12 to 23 weeks (57) or 7 to 28 weeks of age (58) have reported positive correlation between obesity and bone mineral density, associated with higher femoral trabecular thickness and mineral content and higher cortical bone area and thickness despite lower bone formation and high marrow adiposity.…”

“…This was consistent with some (43,55) but not other studies (49,50,(56)(57)(58)(59)(60) . Studies using C57BL/6J male mice fed with HFD from 4 to 23 weeks (56) , 12 to 23 weeks (57) or 7 to 28 weeks of age (58) have reported positive correlation between obesity and bone mineral density, associated with higher femoral trabecular thickness and mineral content and higher cortical bone area and thickness despite lower bone formation and high marrow adiposity. Conversely, other studies stated deleterious effects in the distal femur and proximal tibia including lower trabecular BV/TV, increased bone turnover, and higher RANKL, TNF, and PPAR-gamma along with higher marrow adiposity and lower fracture resistance (49,50,59,60) .…”