Effects of Diet and Exercise on Insulin Resistance during Pregnancy

Clapp, James F.

doi:10.1089/met.2006.4.84

Cited by 84 publications

(54 citation statements)

References 43 publications

(54 reference statements)

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“…Previous researches have shown insulin resistance was significantly increased in late pregnancy compared with either control or early pregnancy (Kirwan et al, 2002;Melczer et al, 2002). This difference may be related to differences in dietary composition, life style between western and eastern societies (Clapp, 2006;Sivabalan et al, 2008), variability between insulin assays in different experimental researches, differences in the population studied and sampling time during pregnancy (Manley et al, 2008).…”

Section: Discussionmentioning

confidence: 96%

Interleukin-10, Mean Arterial Blood Pressure and Insulin Resistance in Normal Pregnancy

Jahromi¹,

Farjam²,

Davami³

et al. 2011

OnLine Journal of Biological Sciences

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Problem statement:The purpose of this study was to investigate whether serum of Interleukin-10 (IL-10) Concentration change during normal pregnancy and, if so, to relate these changes corresponding alterations in insulin resistance and blood pressure. Approach: This cross sectional study was carried out on 86 healthy pregnant women including 26, 23 and 37 individuals in the 1st, 2nd and 3rd trimesters, respectively and in 21 healthy non pregnant women. Serum IL-10 concentration was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Insulin resistance value was calculated using the homeostasis model assessment, HOMA-IR. Results: Serum IL-10 concentration was found to be significantly higher in patients in all gestational age as compared non pregnant women. Il-10 level was significantly increased with increase in gestational age. Pregnant women exhibited higher score of HOMA IR compared non pregnant women, but there were no difference in this score between pregnant subjects in different gestational age. There were not significant correlation between IL-10 level with IR and blood pressure. Conclusion: The results of the study show maternal IL-10 level increase with further increase in gestational age and there is no significant correlation between IL-10 level with Mean Arterial blood Pressure (MAP) and IR.

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Section: Discussionmentioning

confidence: 96%

Interleukin-10, Mean Arterial Blood Pressure and Insulin Resistance in Normal Pregnancy

Jahromi¹,

Farjam²,

Davami³

et al. 2011

OnLine Journal of Biological Sciences

View full text Add to dashboard Cite

show abstract

“…Kirwan et al (2002);Melczer (2002); Stanley et al (1998) have been shown insulin resistance was significantly increased in late pregnancy compared with either control or early pregnancy. This difference may be related to differences in dietary composition, life style between western and eastern societies (Clapp, 2006), variability between insulin assays in different experimental researches (Manley et al, 2008), differences in the population studied and sampling time during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Do Resistin and Tumor Necrosis Factor-Î± Relate to Changes in Insulin Resistance in Normal Pregnancy?

Zareian¹,

Jahromi²,

Rad³

et al. 2010

American Journal of Biochemistry and Biotechnology

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Problem statement:The purpose of this study was to evaluate the role of resistin and Tumor Necrosis Factor-α (TNF-α) in insulin resistance during pregnancy. Approach: Serum resistin and TNF-α concentrations were measured by ELISA in 86 healthy pregnant women (26, 23 and 37 of them in the 1st, 2nd and 3rd trimesters, respectively) and in 21 healthy non pregnant women in a cross sectional study. Results: Resistin concentration was significantly higher in the third trimester (9.5±3.3 ng mL −1 ) as compared with non pregnant women (7±3.3 ng mL −1 ). Serum TNF-α level were also significantly increase in pregnant women (2.6±1.9 pg mL −1 ) as compared with maternal healthy controls (0.8 ±0.7 pg mL −1 ). There were significant correlation between gestational age and BMI (r = 0.28, p = 0.01), resistin (r = 0.36, p = 0.002) and TNF-α (r = -0.44, p<0.0001). There was not significant correlation between gestational age and Insulin Resistance (IR). We also did not found correlation between IR and resistin as well as between IR and TNF-α in pregnant women. Conclusion: TNF-α and resistin do not appear to contribute greatly to pregnancy induced insulin resistance in healthy pregnancy.

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“…The limited evidence from physical activitybased interventions suggests that in order to be more successful in preventing the deterioration of glucose tolerance and insulin sensitivity, pregnant women should engage in regular physical activity at least three times per week at moderate intensity for 30 minutes or more [42][43][44][45][46][47]. However, since glucose response to exercise is influenced by several factors, such as exercise modality, duration, and intensity [48][49][50], further research is needed.…”

Section: Physical Activitymentioning

confidence: 99%

The Prevention of Gestational Diabetes

Cagnazzo¹,

Caserta²

2013

J Diabetes Metab

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The negative impact of the gestational diabetes on the maternal and fetal health is well known and this impact is closely related to gestational age at which the diagnosis is done. Therefore, the use of therapeutic options able to prevent or delay the gestational diabetes occurrence has a positive impact on maternal and neonatal outcomes.Physical activity and dietary advice represent the first choice and they are the most studied as well. They represent a non-pharmacological option and have a positive impact on insulin resistance although they do not seem to prevent the gestational diabetes onset.The preconceptional use of metformin in women with polycystic ovary syndrome protects the pancreatic beta cell reserve preventing or delaying the occurrence of gestational diabetes. However, there are also doubts on the drug safety in pregnancy since it completely crosses the placenta.From this point of view, the inositol could represent an excellent alternative.Its role as insulin sensitizing agent is well documented on improving both the hormonal and reproductive parameters. However, the studies on its preconceptional use in preventing gestational diabetes are too limited though the first results are extremely encouraging.

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Effects of Diet and Exercise on Insulin Resistance during Pregnancy

Cited by 84 publications

References 43 publications

Interleukin-10, Mean Arterial Blood Pressure and Insulin Resistance in Normal Pregnancy

Interleukin-10, Mean Arterial Blood Pressure and Insulin Resistance in Normal Pregnancy

Do Resistin and Tumor Necrosis Factor-Î± Relate to Changes in Insulin Resistance in Normal Pregnancy?

The Prevention of Gestational Diabetes

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