Effects of diet and exercise on adipocytokine levels in patients with moderate to severe chronic kidney disease

Aydemir, Nihal; Pike, Mindy; Alsouqi, Aseel; Headley, Samuel; Evans, Elizabeth; Milch, Charles; Moody, Kelsey Anne; Germain, Michael J.; Lipworth, Loren; Himmelfarb, Jonathan; İkizler, T. Alp; Robinson‐Cohen, Cassianne

doi:10.1016/j.numecd.2020.04.012

Cited by 11 publications

(12 citation statements)

References 32 publications

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“…Hunan is in southern China where rice is the staple food, which contains twice the amount of water and half of the energy as the same amount of steamed bread consumed in northern China 20 . Dietary restriction, exercise and attempting to attain a certain body type are the important reasons for underweight among young women in China 21 . The proportion of overweight/obese (15.48%) women in Hunan Province was consistent with the average in China, but is much lower than that in high-income countries, which was reported to be approximately 55.8% in the USA 22 , 23 .…”

Section: Discussionmentioning

confidence: 99%

Effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women based on a retrospective cohort

Xie

Yang

Wang

et al. 2021

Sci Rep

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To investigate the prevalence of underweight, overweight and obesity as defined by pre-pregnancy body mass index (BMI) and the relationship between pre-pregnancy BMI and pregnancy and perinatal outcomes in women based on a retrospective cohort. Women registered via the Free Pre-pregnancy Health Check (FPHC) program from 2017 to 2019 in Hunan Province, China, were included to the study cohort. The data regarding maternal characteristics, pregnancy outcomes, and infant characteristics were retrieved from the surveillance system of the FPHC program. Logistic regressions were performed to calculate odds ratios (ORs) and adjusted odds ratios (AORs) with 95% confidence intervals (95% CIs) to assess the associations between pre-pregnancy BMIs and the outcomes. Among a total of 398,368 women, 54,238 (13.62%) were underweight (BMI < 18.5 kg/m2), 51,251 (12.87%) were overweight (24.0 kg/m2 ≤ BMI < 28.0 kg/m2), and 10,399 (2.61%) were obese (BMI ≥ 28.0 kg/m2). Underweight occurred more commonly in the 20–24 years old (17.98%), Han Chinese (13.89), college-educated (16.09%), rural (13.74%), and teacher/public servant/office clerk (16.09%) groups. Obesity occurred more often in the older than 35-year-old (4.48%), minority (3.64%), primary school or below (4.98%), urban (3.06%), and housewife (3.14%) groups (P < 0.001). Compared with the normal BMI group, underweight was associated with increased risk of low birth weight (LBW) (AOR = 1.25) and small-for-gestational age (SGA) (AOR = 1.11), but protected against gestational hypertensive disorder (GHD) (AOR = 0.85), gestational diabetes mellitus (GDM) (AOR = 0.69), macrosomia (AOR = 0.67), post-term pregnancy (AOR = 0.76), and cesarean-section (AOR = 0.81). Overweight and obesity were associated with increased risk of GHD (AOR = 1.28, 2.47), GDM (AOR = 1.63, 3.02), preterm birth (AOR = 1.18, 1.47), macrosomia (AOR = 1.51, 2.11), large-for-gestational age (LGA) (AOR = 1.19, 1.35), post-term pregnancy (AOR = 1.39, 1.66), and cesarean- section (AOR = 1.60, 2.05). Pre-pregnancy underweight is relatively common in Hunan Province, China. Pre-pregnancy underweight to some extent is associated with better maternal outcomes, but it has certain adverse effects on neonatal outcomes. Pre-pregnancy overweight, especially obesity, has a substantial adverse effect on pregnancy and perinatal outcomes.

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Section: Discussionmentioning

confidence: 99%

Effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women based on a retrospective cohort

Xie

Yang

Wang

et al. 2021

Sci Rep

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“…Such responses include AMPK activation, autophagy, ROS elimination, Nrf2 signaling pathway activation and enhancement of antioxidative capacity in the kidney [ 231 , 232 , 233 , 234 , 235 ]. In certain studies, exercise has been shown to have a synergistic effect on CR [ 236 , 237 ]. Therefore, CR and exercise may be applied simultaneously to enhance kidney function in diabetes [ 238 , 239 ].…”

Section: Therapeutic Approaches To Counteracting Dkdmentioning

confidence: 99%

NADH/NAD+ Redox Imbalance and Diabetic Kidney Disease

2021

Biomolecules

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Diabetic kidney disease (DKD) is a common and severe complication of diabetes mellitus. If left untreated, DKD can advance to end stage renal disease that requires either dialysis or kidney replacement. While numerous mechanisms underlie the pathogenesis of DKD, oxidative stress driven by NADH/NAD+ redox imbalance and mitochondrial dysfunction have been thought to be the major pathophysiological mechanism of DKD. In this review, the pathways that increase NADH generation and those that decrease NAD+ levels are overviewed. This is followed by discussion of the consequences of NADH/NAD+ redox imbalance including disruption of mitochondrial homeostasis and function. Approaches that can be applied to counteract DKD are then discussed, which include mitochondria-targeted antioxidants and mimetics of superoxide dismutase, caloric restriction, plant/herbal extracts or their isolated compounds. Finally, the review ends by pointing out that future studies are needed to dissect the role of each pathway involved in NADH-NAD+ metabolism so that novel strategies to restore NADH/NAD+ redox balance in the diabetic kidney could be designed to combat DKD.

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“…Therefore, it is possible that visceral fat loss can increase adiponectin levels in overweight subjects [14]. It should be emphasized that though hypoadiponectinemia is an important risk factor for metabolic disorders [13,21], adiponectin levels are higher in CKD patients and have been associated with CKD progression [12,16,[19][20][21]. Song et al speculate that serum adiponectin is a biomarker of renal dysfunction rather than a true risk factor, intimately involved in CKD progression [21].…”

Section: Discussionmentioning

confidence: 99%

“…The factors related to both metabolic disorders, including obesity and chronic kidney disease, are adiponectin and ghrelin. Adiponectin is a cytokine produced by adipose tissue [12][13][14][15][16][17][18][19][20][21]. It is cleared rapidly from the circulation primarily by the liver, involving in part the biliary route, and secondarily by the kidneys [12][13][14]16].…”

Section: Introductionmentioning

confidence: 99%

“…Despite high prevalence of metabolic disorders (e.g., insulin resistance) patients with renal disease have paradoxically higher serum adiponectin levels than subjects with normal kidney function [12,13,23]. What is more, elevated adiponectin concentration in established chronic kidney disease positively predict progression of disease [13,16,[18][19][20][21]23], what can be associated with the fact that kidneys express and secrete adiponectin which is increased upon inflammatory stimulus [15,[19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Nutritional Status, Selected Nutrients Intake and Their Relationship with the Concentration of Ghrelin and Adiponectin in Patients with Diabetic Nephropathy

et al. 2021

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Background: Overnutrition is one of the risk factors of chronic kidney disease (CKD). The factors related to both obesity and CKD are adiponectin and ghrelin. The aim of the study was to assess if there is a link of nutritional status and selected nutrients intake with adiponectin and ghrelin in patients with diabetic nephropathy (DN). Methods: The study involved 55 patients diagnosed with DN in the pre-dialysis period (two groups: GFR < 30 and >30 mL/min/1.73 m2). In all participants standard blood tests, total ghrelin and total adiponectin plasma concentrations and anthropometric measurements (BMI, WHR- waist–hip ratio, body composition analysis) were performed. The evaluation of energy and nutrient intakes was made using the three-day food record method. Results: Excessive body weight was found in 92.80% patients. The average daily energy intake was 1979.67 kcal/day (14.45% protein energy, 28.86% fat, and carbohydrates 56.89%). In the group with eGFR < 30 mL/min/1.73 m2 the analysis showed a negative relationship between ghrelin and WHR value, and the creatine and albumin concentrations. There was a positive correlation between ghrelin concentration and the consumption of carbohydrates and sucrose. In the group of patients with eGFR > 30 mL/min/1.73 m2, a positive correlation was found between the concentration of ghrelin and the consumption of vegetable protein, carbohydrates, and glucose. Conclusions: The study confirms the high prevalence of obesity in patients with DN-Excessive supply of protein was found in the patients’ diets, which may contribute to the deterioration of the course of the disease and its prognosis. In patients with eGFR < 30 there was a negative correlation between ghrelin concentration and nutritional status, and in patents with eGFR > 30 between ghrelin concentration and some nutrients intake.

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Effects of diet and exercise on adipocytokine levels in patients with moderate to severe chronic kidney disease

Cited by 11 publications

References 32 publications

Effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women based on a retrospective cohort

Effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women based on a retrospective cohort

NADH/NAD+ Redox Imbalance and Diabetic Kidney Disease

Nutritional Status, Selected Nutrients Intake and Their Relationship with the Concentration of Ghrelin and Adiponectin in Patients with Diabetic Nephropathy

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