1974
DOI: 10.1620/tjem.113.357
|View full text |Cite
|
Sign up to set email alerts
|

Effects of Dibutyryl Cyclic AMP on contractile Performance of Isolated Heart Muscle Depressed by Thiamylal and Halothane

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
4
0

Year Published

1975
1975
1993
1993

Publication Types

Select...
5

Relationship

2
3

Authors

Journals

citations
Cited by 6 publications
(4 citation statements)
references
References 5 publications
(2 reference statements)
0
4
0
Order By: Relevance
“…Sprague et al have suggested that halothane inhibits phenylephrine-induced aortic contraction by stimulating cAMP formation (23). The myocardial depressive effects of halothane and the barbiturate thiamylal on isolated dog myocardium can be reversed by exogenous dibutyryl cAMP, further suggesting that the site of action of these agents occurs before cAMP's effect (24). Triner et al (25) have recently demonstrated halothane-induced activation of adenylate cyclase in bronchial and uterine smooth muscle.…”
Section: Inhibition Of Water Flow By General Anesthetics 985mentioning
confidence: 99%
“…Sprague et al have suggested that halothane inhibits phenylephrine-induced aortic contraction by stimulating cAMP formation (23). The myocardial depressive effects of halothane and the barbiturate thiamylal on isolated dog myocardium can be reversed by exogenous dibutyryl cAMP, further suggesting that the site of action of these agents occurs before cAMP's effect (24). Triner et al (25) have recently demonstrated halothane-induced activation of adenylate cyclase in bronchial and uterine smooth muscle.…”
Section: Inhibition Of Water Flow By General Anesthetics 985mentioning
confidence: 99%
“…A similar finding was observed in dibutyryl cyclic AMP (Iwatsuki and Iwatsuki 1974). Since a positive inotropic effect of dibutyryl cyclic AMP is considered to be due to increased Ca++ available to the myofibrils in the sarcoplasm (Robinson et al 1965;Entman et al 1969; Drummond and Hemm ings 1972), the mechanisms related to Ca++ in contraction may be responsible to and Halothane and Myocardial Contractility 7…”
Section: Discussionmentioning
confidence: 56%
“…It has been also recognized that a positive inotropic effect of catecholamines (Langer 1973) or an increase in the frequency of stimulation (Grossman and Furchgott 1964;Teiger and Farah 1967) is closely related to the intracellularly increased Ca++ concentration of the myocardium. Previously we reported that, in the isolated dog heart muscle, the depression of myocardial contractility produced by thiamylal was easily reversed by dibutyryl cyclic AMP, while the depression produced by halothane resisted the counteraction of this agent (Iwatsuki and Iwatsuki 1974). It was also reported that the myocardium depressed by thiamylal or halothane showed a positive staircase phenomenon in contractility following an increase in the frequency of stimulation (Iwatsuki and Iwatsuki 1975).…”
mentioning
confidence: 94%
“…Krishna and Paradise (1972) have reported that pyruvate administered into the bathing medium reverses the myocardial depression produced by halothane, but it is ineffective for the reversal of depression produced by pentobarbital. Recently we have demonstrated in isolated heart muscle that the myocardial depression produced by thiamylal is reversed readily by dibutyryl cyclic AMP, but the depression produced by halothane resists to the antagonizing effect of this agent (Iwatsuki and Iwatsuki 1974) . These two findings suggest that the mechanism of myocardial depression may be different between thiamylal and halothane.…”
mentioning
confidence: 99%