Effects of diazepam on neutrophil (PMN) free amino acid profiles and immune functions in vitro. Metabolical and immunological consequences of L-alanyl-L-glutamine supplementation

Mühling, J.; Sablotzki, Armin; Fuchs, Markus; Krüll, Matthias; Dehne, M. G.; Weiß, Stefan; Gonter, Jens; Quandt, Diana; Hempelmann, G.

doi:10.1016/s0955-2863(00)00144-3

Cited by 7 publications

(1 citation statement)

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“…Experimental and clinical evidences suggested that benzodiazepines could influence immune cell properties, such as phagocyte activity, chemotaxis and the production of superoxide, and cytokines; either by reducing the stress and anxiety or through stimulation of Peripheral Benzodiazepine Receptors (PBRS) [4]. These PBRS have been identified mainly into the mitochondria of non-neuronal peripheral cells as adrenocortical cells [5] and also, in the cellular components of the immune system, such as monocytes, neutrophils, macrophages [6].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Effects of Diazepam on Different Models of Inflammation: Roles ofPeripheral Benzodiazepine Receptors and Genes for Corticosterone, Nitric Oxide andCytokines Biosynthesis

Bader¹,

Omar²,

El-Odemi³

2017

J Clin Epigenet

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Effects of Diazepam on Different Models of Inflammation: Roles ofPeripheral Benzodiazepine Receptors and Genes for Corticosterone, Nitric Oxide andCytokines Biosynthesis

Bader¹,

Omar²,

El-Odemi³

2017

J Clin Epigenet

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Sedation and the Immune System

Villa

Mega

Senzi

2017

Critical Care Sedation

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Benzodiazepine receptor-dependent modulation of neutrophil (PMN) free amino- and ?-keto acid profiles or immune functions

et al. 2004

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We have examined the effects of midazolam, Ro 5-4864 (agonist for "peripheral" [p] benzodiazepine receptors [BR]), PK 11195 (antagonist for pBR), flumazenil (antagonist for "central" BR), naloxone (antagonist for opiate receptors) and the combination of midazolam and Ro 5-4864, PK 11195, flumazenil or naloxone on intracellular amino- and alpha-keto acids and the immune function markers superoxide anion (O(2)(-)), hydrogen peroxide (H(2)O(2)) and released myeloperoxidase (MPO) activity in neutrophils (PMN). Only midazolam and Ro 5-4864 led to significant changes in the dynamic PMN free amino- and alpha-keto acid pools. Concerning PMN immune function markers, midazolam and Ro 5-4864 significantly decreased O(2)(-) and H(2)O(2) formation and released MPO. When midazolam and Ro 5-4864 were applied together they appeared to act additively. Pre-incubation with PK 11195 partially neutralized the midazolam effects whereas flumazenil or naloxone showed no effects. We therefore believe that pBR are involved in the signal transmission of anesthetic-induced cellular metabolic changes in PMN.

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Effects of diazepam on neutrophil (PMN) free amino acid profiles and immune functions in vitro. Metabolical and immunological consequences of L-alanyl-L-glutamine supplementation

Cited by 7 publications

References 50 publications

Anti-inflammatory Effects of Diazepam on Different Models of Inflammation: Roles ofPeripheral Benzodiazepine Receptors and Genes for Corticosterone, Nitric Oxide andCytokines Biosynthesis

Anti-inflammatory Effects of Diazepam on Different Models of Inflammation: Roles ofPeripheral Benzodiazepine Receptors and Genes for Corticosterone, Nitric Oxide andCytokines Biosynthesis

Sedation and the Immune System

Benzodiazepine receptor-dependent modulation of neutrophil (PMN) free amino- and ?-keto acid profiles or immune functions

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