Effects of diazepam and β-CCM on working memory in mice: relationships with emotional reactivity

Krazem, Ali; Borde, Nathalie; Béracochéa, Daniel

doi:10.1016/s0091-3057(00)00444-5

Cited by 20 publications

(19 citation statements)

References 26 publications

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“…The capability of a Benzodiazepine receptor inverse agonist to enhance acquisition and/or consolidation processes has been established in several different memory tasks [30][31][32]4]. The dose of β-carboline required for enhancing memory is usually lower than the dose required for eliciting anxiogenic actions [5,26] and this rule was replicated in our study.…”

Section: Discussionsupporting

confidence: 71%

“…It is well-established that agonists at the benzodiazepine site, of these receptor notably benzodiazepines, have anxiolytic and amnesic properties whereas β-carboline alkaloids as benzodiazepine receptor inverse agonist exert anxiogenic and learning-enhancing actions by antagonizing the action of benzodiazepines on GABA-A receptors [1][2][3][4][5]. A number of β-carboline alkaloids such as harmane (1-methyl-9H-pyrido- [3,4-b]indole) (HA) 1-methyl-β-carboline), harmaline (1-methyl-7-methoxy-3, 4-dihydro-β-carboline) and NO (9H-pyrido [3,4-b] indole), exist naturally in plant derived food products (wheat, rice, corn, barley, soybeans, rye, grapes, mushrooms, and vinegar), plant derived beverages (wine, beer, whisky, brandy, and sake), and plant derived inhaled substances (tobacco) [6].…”

Section: Introductionmentioning

confidence: 99%

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Low and high doses of Norharmane respectively improve and impair learning and memory in streptozotocin-induced rat model of sporadic alzheimer’s disease

Hossein¹,

Charmchi²,

Behnaz³

2017

Alzheimers Dement Cogn Neurol

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Low and high doses of Norharmane respectively improve and impair learning and memory in streptozotocin-induced rat model of sporadic alzheimer’s disease

Hossein¹,

Charmchi²,

Behnaz³

2017

Alzheimers Dement Cogn Neurol

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“…act through the benzodiazepine binding site: positive (agonist), neutral (antagonist), and negative (inverse agonist) modulators [3]. It is established that agonists at the benzodiazepine site present anxiolytic and amnesic properties, whereas inverse agonists could exert opposite actions [4,5]. Recent genetic studies with mice carrying a point mutation in α1, α2, α3 or α5 subunits have suggested a specifi c contribution of individual receptor subtypes to the spectrum of behavioral actions of these compounds [6].…”

Section: Research Articlementioning

confidence: 99%

Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test

Samardžić¹,

Puškaš²,

Obradović³

et al. 2014

Acta Veterinaria

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It has been shown in electrophysiological studies that the ligand L-655,708 possesses a binding selectivity and a moderate inverse agonist functional selectivity for α5-containing GABA-A receptors. The present study is aimed to investigate the antidepressant effects of the ligand L-655,708 in the forced swim test (FST) and its impact on locomotor activity in rats. The behavior of the animals was recorded with a digital camera, and the data were analyzed by one-way ANOVA, followed by Dunnett’s test. In FST, L-655,708 significantly decreased immobility time at a dose of 3 mg/kg after a single and repeated administration (p<0.05), exerting acute and chronic antidepressant effects. However, it did not induce significant differences in the time of struggling behavior during FST. Furthermore, L-655,708 did not show a significant effect on locomotor activity (p>0.05). These data suggest that negative modulation at GABA-A receptors containing the α5 subunit may produce antidepressant effects in rats. These effects were not confounded by locomotor influences.

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“…This sequential procedure relies on working memory since the ability to alternate requires that the subject retain specific information, which varies from trial to trial. It is also sensitive to various manipulations (ie delay intervals, increased number of trials) and pharmacological treatments affecting memory processes (Tako et al, 1988;Ragozzino et al, 1994;Krazem et al, 2001;Stefani and Gold, 2001). …”

Section: Cognitive Studiesmentioning

confidence: 99%

Cognitive Enhancing Properties and Tolerability of Cholinergic Agents in Mice: A Comparative Study of Nicotine, Donepezil, and SIB-1553A, a Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors

Bontempi¹,

Whelan²,

Risbrough³

et al. 2003

Neuropsychopharmacol

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Several studies have demonstrated the importance of nicotinic mechanisms in the pathophysiology of neurodegenerative and cognitive disorders, warranting the search and development of novel nicotinic ligands as potential therapeutic agents. The present study was designed to assess whether the subtype-selective nicotinic acetylcholine receptor (nAChR) ligand SIB-1553A [( 7 )-4-{[2-(1-methyl-2-pyrrolidinyl)ethyl]thio}phenol hydrochloride], with predominant agonist activity at b4 subunit-containing human nAChRs, and no activity at muscle nAChR subtypes, could enhance cognitive performance in rodents with a more desirable safety/tolerability profile as compared to the nonselective prototypic nAChR ligand nicotine. SIB-1553A was equi-efficacious to nicotine in improving working memory performance in scopolamine-treated mice as measured by increased alternation in a T-maze, and was more efficacious than nicotine in improving the baseline cognitive performance of aged mice. This effect on working memory was confirmed in a delayed nonmatching to place task using the eight-arm radial maze. SIB-1553A produced dose-dependent side effects (ie motor deficits and seizures), although these effects were observed at doses 12 to 640-fold above those required to increase cognitive performance. Overall, SIB-1553A was significantly less potent than nicotine in eliciting these undesirable effects. Thus, the subtype-selective profile of SIB-1553A appears to translate into a more efficacious and better tolerated nAChR ligand as compared to nicotine. In the present studies, cognitive enhancement induced by SIB-1553A was similar in magnitude to that produced by the clinically efficacious acetylcholinesterase inhibitor donepezil. Taken together, the present data confirm the importance of nAChR subtypes in modulating cognitive processes, and suggest that activation of nAChR subtypes by selective nAChR ligands may be a viable approach to enhance cognitive performance.

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Effects of diazepam and β-CCM on working memory in mice: relationships with emotional reactivity

Cited by 20 publications

References 26 publications

Low and high doses of Norharmane respectively improve and impair learning and memory in streptozotocin-induced rat model of sporadic alzheimer’s disease

Low and high doses of Norharmane respectively improve and impair learning and memory in streptozotocin-induced rat model of sporadic alzheimer’s disease

Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test

Cognitive Enhancing Properties and Tolerability of Cholinergic Agents in Mice: A Comparative Study of Nicotine, Donepezil, and SIB-1553A, a Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors

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