Effects of diabetes mellitus type I on skeletal muscle: an integrative review

Abstract

Introduction: The Diabetes Mellitus (DM) is considered a serious public health problem in Brazil and in the world, increased by the modern life style, characterized by reduced physical activity, increased obesity and aging of the population. The diabetic myopathy is characterized as a complication in the striated skeletal muscles caused by diabetes, characterized by decreased muscle mass, weakness and reduced physical capacity. Thus the present study aimed to review in the literature the main changes suffered by muscle cells associated with Diabetes Mellitus type I. Material and Methods: The present review regards to the major studies in digital databases about the effects of DM type I on the morphology of the skeletal muscles. The search for references was performed in the following databases: Medical Literature and Retrieval System Online (MEDLINE/ PUBMED), Google Scholar and Scientific Electronic Library Online (SCIELO). Articles should have the following criteria to enter in the research: articles published in the last ten years, in English, Portuguese or Spanish and available online. Results: The database that had the highest number of publications was MEDLINE (98), followed by SCIELO (56) and Google Scholar (43). Only, 4 articles were selected. The articles were described according to the year of publication, title of work, journal and objectives. Conclusion: This review shows a clear association between diabetes mellitus type I and changes in skeletal muscle. The risks of atrophy in the muscles, especially the members, were significantly higher in patients with this syndrome than in normal patients. Which makes the issue of fundamental importance to the area of health.

Effects of Breast Cancer and Type 2 Diabetes Mellitus on Pulmonary Volumes and Pressures in Adult Women

“…This is due to the double function of the abdominal muscles, which are a fundamental part of the coughing mechanism [25] their tone fluctuates constantly depending on posture [26]; and ii) the results obtained for MIP-IC presented a diminution which expresses the proposed relation between them, supported by the observations of Fadil et al (2015), who determined a parallel reduction between pressures and volumes in subjects with DM2 [27]. Investigations in mice with DM showed diminished capillarisation and angiogenesis in the skeletal muscle, resulting in smaller fibre size and muscle belly; in the long term these alterations will generate a reduction in muscle functioning [28].…”

“…Likewise, when BC is combined with DM, a significant diminution was found compared to the CG, and we therefore attribute this greater diminution to the sum of the two conditions. This indicates that there are two phenomena acting in parallel on the respiratory system: on the one hand DM, which, as explained above, diminishes muscle mass and strength [28]; and on the other cancer and its treatment, which provoke various alterations in the ventilation system such as loss of pneumocytes and tensioactive agent, and the appearance of oedema in the basal membrane [23]. These changes in conjunction would reinforce one another, generating a greater diminution of IC as compared to the other groups.…”

Representação social sobre saúde em uma escola no Rio de Janeiro

“…Esse cenário pode ser reforçado por inúmeras publicações que procuram estabelecer uma relação de causa e efeito entre atividade física e saúde, tendo a atividade física como um remédio para esses males [29][30][31][32][33][34] .…”

Investigation of the Effect of Diabetes on Lower Limb Muscles with Surface Electromyography (EMG)

“…In addition to growth and function, TIDM has been shown to impair the ability to repair damage, as evidenced by studies of muscle regeneration using chemical and genetic models of TIDM. Overall, these investigations show that TIDM has a deleterious influence on skeletal muscle and its ability to grow, maintain, and repair [9]. Muscle growth and development are significantly impaired in Type I Diabetes Mellitus (TIDM), resulting in reduced muscle mass and myofiber size, poor metabolic control, and a switch to a glycolytic phenotype.…”