Effects of dextrans on the plasma protein changes during the postoperative period

Skrede, Sverre; Rø, Johannes; Mjølnerød, Ove Kr.

doi:10.1016/0009-8981(73)90359-8

Cited by 5 publications

(1 citation statement)

References 26 publications

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“…This protein, as well as other macromolecules, increases ESR by stimulating erythrocyte aggregation; a mechanism which far outweighs the retarding ePfect on ESR of the simultaneously increased plasma viscosity. Thirdly, the ESR-increase during dextran treatment cannot be explained by changes of other high molecular weight proteins, such as the immunoglobulins, since their concentrations were also reduced (Skrede et al, 1973). The haematocrit also influences the ESR and usclally these parameters are inversely related (Dintenfass, 1971).…”

Section: Discussionmentioning

confidence: 99%

Haemostatic Parameters and Erythrocyte Sedimentation Rate in Dextran-Warfarin Treated Vascular Surgical Patients

Rø¹,

Kluge²,

Taksdal³

et al. 1974

Scandinavian Journal of Thoracic and Cardiovascular Surgery

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Haematological tests and parameters of coagulation and fibrinolysis were studied in 13 patients given postoperative thrombosis prophylaxis with dextran 70 (Macrodex) or dextran 40 (Rheomacrodex), combined with warfarin. The same parameters were examined in a control group of 20 patients. Dextrans, in particular dextran 70, induced an increase of the erythrocyte sedimentation rate (ESR) which by far exceeded the normal postoperative BSR-elevation. Hyperfibrinogenaemia, which is probably the main cause of the usual postoperative ESRincrease, was far less pronounced, or absent, in the dextran-treated patients. The extent of fibrinogen consumption and fibrinolysis seemed to he uninfluenced by the dextran treatment. An accumulation of high molecular weight fractions of dextran in serum occurred during the treatment, and this is probably the main cause of the altered ESR-respcnse. The dextran trzatment did not intraduce errors in the control of anticoagulant thzrapy with Thrombotest (TT). Bleeding was not induced by the combined prophylaxis with dextran and warfarin, provided the TT-values were above 7 % . PreparationsRheomacrodex 10 % in saline. Average molecular weight (fiw) 40000, with more than 90% between I & 10000 and R, 80 000. Abbreviation: dextran 40.Macrodex 6 % in saline. M, 70 000, with more than 90% between 25 OOO and 125 000. Abbreviation: dextran 70. These preparations were purchased from Pharmacia, Uppsala, Sweden.Marevan (warfarin sodium), Nyegaard & CO., Oslo, Norway. MethodsThrombosis prophylaxis. Warfarin treatment was started several days prior to surgery. The dosage was guided by the TT-values, aiming at a level between 7 and 15% before, during and after surgery. Scand Cardiovasc J Downloaded from informahealthcare.com by UB Giessen on 11/01/14For personal use only. , , Scand J Thor Cardiovasc Surg 8 Scand Cardiovasc J Downloaded from informahealthcare.com by UB Giessen on 11/01/14 For personal use only.

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Section: Discussionmentioning

confidence: 99%