Effects of Dextran 40 on Erythrocyte Aggregation

Engeset, J; Stalker, Amy; Matheson, N. A.

doi:10.1016/s0140-6736(66)91138-x

Cited by 16 publications

(12 citation statements)

References 5 publications

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“…All rouleaux were disrupted by the addition of 7*0 g/100 ml. These results are comparable with those reported by Engeset et al (1966). DISCUSSION These results show that rouleaux have no effect on the rate of packing produced by a centrifugal field of about 200 g. Similarly, aggregate formation has been shown to be of no influence in this context.…”

Section: Low Molecular Weight Dextran and Rouleaux Formationsupporting

confidence: 90%

The interactions of fibrinogen and dextrans with erythrocytes

Rampling¹,

Sirs²

1972

The Journal of Physiology

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SUMMARY1. The rate of packing of erythrocytes in whole blood, under a centrifugal field of 200 9, has been studied using an automatic recording centrifuge.2. Reduction of the supernatant fibrinogen concentration, by repeatedly washing the cells, lowers the rate of packing and reduces the cell flexibility.3. Resuspending the cells in their own plasma or in isotonic solutions containing fibrinogen restores their flexibility.4. Rouleaux formation has been shown to have no effect on the rate of packing by comparison of blood diluted with plasma, isotonic NaCl or Ringer-Locke solutions. While the degree of rouleaux formation varied with the diluent used, the rate of packing and packed cell haematocrit were the same, for the same dilution.5. Both formalin and dextran altered the degree of rouleaux formation and reduced erythrocyte flexibility. Dextran was found to act indirectly on the erythrocyte flexibility by reducing the plasma fibrinogen concentration.

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Section: Low Molecular Weight Dextran and Rouleaux Formationsupporting

confidence: 90%

The interactions of fibrinogen and dextrans with erythrocytes

Rampling¹,

Sirs²

1972

The Journal of Physiology

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“…The degree of departure of this clumping from normal in vitro is dependent on the colloid composition of the plasma, in particular the ratio of high to low molecular weight colloids (Thorsen & Hint, 1950). A normal degree of clumping can be made much worse by the addition to blood of a high molecular weight colloid (Thorsen & Hint, 1950;Engeset, Stalker & Matheson, 1966). Gross abnormalities in red cell dispersion can thus be induced in vitro by the addition to blood of increasing amounts of Dextran of high molecular weight as illustrated by Engeset et al (1966).…”

mentioning

confidence: 99%

“…A normal degree of clumping can be made much worse by the addition to blood of a high molecular weight colloid (Thorsen & Hint, 1950;Engeset, Stalker & Matheson, 1966). Gross abnormalities in red cell dispersion can thus be induced in vitro by the addition to blood of increasing amounts of Dextran of high molecular weight as illustrated by Engeset et al (1966). Such gross abnormalities in red cell dispersion are not limited to in vitro situations.…”

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confidence: 99%

“…In vivo it is now increasingly accepted that blood flow rate is also an important determinant of red cell dispersion. The importance of flow rate is clear from recent microcirculatory studies (Pories et al, 1962;Stalker, 1964;Engeset et al, 1967a) and from the relationship between red cell aggregation and shear rate in vitro. The degree of red cell aggregation or dispersion in the microcirculation is therefore determined by the plasma colloid composition which decides the tendency of the red cells to clump and by the opposing effect of the shearing forces applied to the cell masses as a result of blood flow rate.…”

mentioning

confidence: 99%

“…Severe intravascular aggregation was induced in the microcirculation of rabbit ear chambers by infusion of Dextran molecular weight 250,000 followed by haemoconcentration induced by subcutaneous infiltration of hypertonic dextrose (Engeset et al, 1967a). Thereafter flow was sluggish and the red cells were clumped together in irregular slowly flowing masses in both arterioles and venules.…”

mentioning

confidence: 99%

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The microcirculation in shock

Matheson

1969

Postgraduate Medical Journal

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SummarySome aspects ofblood fluidity in hypoperfusion with particular reference to the important role of the red cell are discussed. Changes in different organ beds and the internal fluidity of the rcd cell, which is of obvious importance in capillary flow are not considered.It is not certain to what extent the phenomena discussed are critical factors in morbidity and mortality in shock because of paucity of objective data but there are good reasons for assuming them to be of importance and for directing treatment towards their correction.The properties of Dextran 40 applicable to the therapy of disordered blood fluidity are described.

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Erythrocyte flexibility, blood fibrinogen and surgery

Sirs¹

1975

Thromboembolism

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Effects of Dextran 40 on Erythrocyte Aggregation

Cited by 16 publications

References 5 publications

The interactions of fibrinogen and dextrans with erythrocytes

The interactions of fibrinogen and dextrans with erythrocytes

The microcirculation in shock

Erythrocyte flexibility, blood fibrinogen and surgery

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