Effects of dexmedetomidine, with or without vatinoxan (MK-467), on minimum alveolar concentration of isoflurane in cats

Pypendop, Bruno H.; Ahokoivu, Hanna; Honkavaara, Juhana

doi:10.1016/j.vaa.2019.02.004

Cited by 15 publications

(10 citation statements)

References 20 publications

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“…Furthermore, in a recent study by Hector et al (2017), vatinoxan unexpectedly increased the minimum alveolar concentration (MAC) of sevoflurane in dogs, an effect speculated to be related to possible CNS penetration by the drug. More recently, similar findings were also reported in cats (Pypendop et al 2019). As the beneficial effects of α 2-adrenoceptor agonists, namely sedation, antinociception and anaesthetic-sparing are mediated at the level of the CNS (Doze et al 1989;Guo et al 1996;Kita et al 2000), significant distribution of vatinoxan across the canine blood-brain barrier would potentially decrease its clinical appeal.…”

Section: Introductionsupporting

confidence: 69%

Concentrations of medetomidine enantiomers and vatinoxan, an α2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs

Honkavaara

Raekallio

Syrja

et al. 2020

Veterinary Anaesthesia and Analgesia

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show abstract

Section: Introductionsupporting

confidence: 69%

Concentrations of medetomidine enantiomers and vatinoxan, an α2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs

Honkavaara

Raekallio

Syrja

et al. 2020

Veterinary Anaesthesia and Analgesia

Self Cite

View full text Add to dashboard Cite

show abstract

“…In cats anesthetized with isoflurane and a constant rate infusion of dexmedetomidine, vatinoxan administration resulted in a higher MAC value than a control group receiving saline instead of vatinoxan (Pypendop et al 2019). This raises questions regarding the drug's capability to cross the blood-brain-barrier in domestic species, requiring further pharmacokinetic studies to determine its concentration in plasma and CNS.…”

Section: Vatinoxanmentioning

confidence: 99%

Use of intravenous lidocaine to treat dexmedetomidine-induced bradycardia in sedated and anesthetized dogs

Tisotti

Valverde

Hopkins

et al. 2021

Veterinary Anaesthesia and Analgesia

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This thesis evaluated the use of intravenous lidocaine to treat the bradycardia associated with the administration of the sedative dexmedetomidine in canine anesthetic protocols. Research Beagle dogs were assigned to three different groups in a randomized crossover design that involved the administration of intravenous dexmedetomidine in different modalities of the anesthetic protocol. In two groups, dexmedetomidine was administered to dogs while awake and in the third group while anesthetized with isoflurane.After receiving dexmedetomidine, dogs were given intravenous lidocaine as a bolus 30 minutes later, followed by a second bolus and a constant rate infusion 20 minutes after the first bolus, in one of the awake groups and the anesthetized group. The other awake group received the lidocaine bolus and constant rate infusion 5 minutes after the dexmedetomidine.Intravenous lidocaine increased heart rate in awake and anesthetized dogs pretreated with intravenous dexmedetomidine. Additional benefits from lidocaine administration included an increase in cardiac index and a decrease in systemic vascular resistance.iii DEDICATIONIn Memoriam of my grandparents Ieda Hainzenreder and João de Mesquita.Foremost, I would like to thank my supervisor, Dr. Alexander Valverde, for opening the doors for me, for being resolute, tireless and for his guidance during my program. I would also like to thank all the anesthesia faculties I had the opportunity to work with and absorb some of their knowledge, but specially to Drs. Andrea Sanchez, Carolyn Kerr and Melissa Sinclair for the personal and professional support along these three years.

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“…Dexmedetomidine (Dexmedesed; Dechra Veterinary Products LLC, KS, USA) was diluted to 0.1 mg mL −1 using sterile 0.9% saline. Vatinoxan and dexmedetomidine were administered by target-controlled infusion as previously described, using previously published pharmacokinetic data obtained in anesthetized cats (Pypendop et al 2019(Pypendop et al , 2020a. The vatinoxan target plasma concentration (TPC) was 1 µg mL −1 and remained constant throughout the study.…”

Section: Conditionsmentioning

confidence: 99%

“…MACISO was determined at each condition (BL, Vat, Vat/Dex5, Vat/Dex10, Vat/Dex20) in each cat during the first treatment (dopamine, phenylephrine or norepinephrine) of the study, according to previously published methods (Pypendop et al 2019). A single MACISO determination was performed for each condition.…”

Section: Maciso Determinationmentioning

confidence: 99%

Effects of dopamine, norepinephrine or phenylephrine on the prevention of hypotension in isoflurane-anesthetized cats administered vatinoxan or vatinoxan and dexmedetomidine

Kobluk

Pypendop

2022

Veterinary Anaesthesia and Analgesia

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Effects of dexmedetomidine, with or without vatinoxan (MK-467), on minimum alveolar concentration of isoflurane in cats

Cited by 15 publications

References 20 publications

Concentrations of medetomidine enantiomers and vatinoxan, an α2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs

Concentrations of medetomidine enantiomers and vatinoxan, an α2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs

Use of intravenous lidocaine to treat dexmedetomidine-induced bradycardia in sedated and anesthetized dogs

Effects of dopamine, norepinephrine or phenylephrine on the prevention of hypotension in isoflurane-anesthetized cats administered vatinoxan or vatinoxan and dexmedetomidine

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