Effects of Dexmedetomidine on Renal Ischaemia Reperfusion Injury in Streptozotocin-Induced Diabetic Rats

Kuzgun, Ozge; Özkardeşler, Sevda; Özbılgın, Şule; Akan, Mert; Ergür, Bekir Uğur; Kamaci, Gonca; Güneli, Mehmet Ensari; Ates, N. Bahar; Şişman, Ali Rιza; Dalak, Reci Meseri

doi:10.5152/tjar.2018.62592

Cited by 1 publication

(3 citation statements)

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Section: Discussionmentioning

confidence: 99%

“…Previous studies were considered when deciding on dexmedetomidine doses. 9,10 For the IR model, the abdomen was dissected under anaesthesia, the abdominal aorta was clamped using a haemostasis clamp for 30 minutes, and then the clamp was removed and the abdominal aorta was reperfused for 2 hours. The rats were sacrificed using the intracardiac blood collection method under deep anaesthesia.…”

Section: Methodsmentioning

confidence: 99%

“…In the study by Kuzgun et al, it was observed that the proximal tubule and total cell damage scores were improved in the groups that received intraperitoneal dexmedetomidine (100 μg/kg) before the renal IR model in rats in which diabetes mellitus was induced using streptozotocin. 10 In another study examining the effects of dexmedetomidine on IR-induced kidney damage, intraperitoneal dexmedetomidine (25 µg/kg) was injected 30 minutes before IR in one group. It was found that focal renal haemorrhage, focal tubular necrosis, neutrophil infiltration, and vacuolar degeneration in renal tubular epithelial cells were significantly lower than in the IR group.…”

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confidence: 99%

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Effects of Dexmedetomidine Administered Through Different Routes on Kidney Tissue in Rats with Spinal Cord Ischaemia–Reperfusion Injury

Şengel

Köksal

Dursun

et al. 2022

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Background Ischaemia–reperfusion (IR) injury, which can be encountered during surgical procedures involving the abdominal aorta, is a complex process that affects distant organs, such as the heart, liver, kidney, and lungs, as well as the lower extremities. In this study, we aimed to contribute to the limited literature by investigating the protective effect of dexmedetomidine, which was administered through different routes, on kidney tissue in rats with spinal cord IR injury. Methods A total of 30 rats were randomly divided into five groups: control (C group), IR (IR group), IR-intraperitoneal dexmedetomidine (IRIPD group), IR-intrathecal dexmedetomidine (IRITD group), and IR-intravenous dexmedetomidine (IRIVD group). The spinal cord IR model was established. Dexmedetomidine was administered at doses of 100 µg/kg intraperitoneally, 3 µg/kg intrathecally, and 9 µg/kg intravenously. Histopathologic parameters in kidney tissue samples taken at the end of the reperfusion period and biochemical parameters in serum were evaluated. Results When examined histopathologically, tubular dilatation was found to be significantly reduced in the IRIVD, IRITD, and IRIPD groups compared with the IR group ( p = 0.012, all). Vascular vacuolization and hypertrophy were significantly decreased in the IRIVD, IRITD, and IRIPD groups compared with the IR group ( p = 0.006, all). Tubular cell degeneration and necrosis were significantly reduced in the IRIVD, IRITD, and IRIPD groups compared with the IR group ( p = 0.008, p = 0.08, and p = 0.030, respectively). Lymphocyte infiltration was significantly decreased in the IRIVD and IRITD groups compared with the IR group ( p = 0.006 and p = 0.06, respectively). Conclusion It was observed that dexmedetomidine administered by different routes improved the damage caused by IR in kidney histopathology. We think that the renoprotective effects of dexmedetomidine administered intravenously and intrathecally before IR in rats are greater.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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