Effects of Dexamethasone on the Pathogenesis of Porcine Circovirus Type 2 Infection in Piglets

Kawashima, Kenji; Tsunemitsu, Hiroshi; Horino, Rieko; Katsuda, Ken; Onodera, Takashi; Shoji, Takeuchi; Kubo, Michinori; Haritani, Makoto; Murakami, Yosuke

doi:10.1016/s0021-9975(03)00047-1

Cited by 22 publications

(27 citation statements)

References 28 publications

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“…2,4,6,8 However, no etiologic agents suggesting mycobacterial infection, 7 brucellosis, 3 mucormycosis, 10 and PMWS 2,4,5,8 were detected in the present cases. Sarcoidosis in humans is a disease characterized by systemic granulomatous lesions without caseous necrosis.…”

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confidence: 57%

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Thymic Granulomatous Lesions in Pigs

Baba¹,

Nakayama²,

Yasoshima³

et al. 2006

Vet Pathol

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Abstract. Rare cases of thymic granulomatous lesions were found in pigs. The lesions consisted of epithelioid cells, multinucleated giant cells, and lymphocytes. Such lesions also were observed in the mesenteric lymph nodes, spleen, kidney, and stomach. The cytoplasm of the majority of giant cells and some epithlioid cells was periodic acid-Schiff (PAS) positive. All cells were positive for vimentin, lysozyme, and desmin. Ultrastructurally, the giant cells were rich in organella and attached to adjacent epithelioid cells by membrane interdigitation. The cells included numerous coated vesicles and granules. No etiologic pathogen, including porcine circovirus type 2, was detected in the lesions. This is the rare case of idiopathic thymic granulomatous lesion in pigs.

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confidence: 57%

“…DNAs were extracted from the paraffin sections of thymus and lymph nodes according to the procedure by Kim and Chae. 5 The protocol for PCR, including primer setting and cycles, was set according to the report by Kawashima et al 4 The positive template used in PCR was prepared from PCV-2-infected cells (a gift from Dr. Kawashima).…”

mentioning

confidence: 99%

Thymic Granulomatous Lesions in Pigs

Baba¹,

Nakayama²,

Yasoshima³

et al. 2006

Vet Pathol

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“…It was concluded that dexamethasone treatment influenced PCV2 infection of lymphoid tissues and that suppression of the cell-mediated immunity may play a role in the etiology of PCVAD. 54 …”

Section: Effect Of Immune Modulationmentioning

confidence: 99%

Porcine Circovirus Type 2–Associated Disease: Update on Current Terminology, Clinical Manifestations, Pathogenesis, Diagnosis, and Intervention Strategies

2007

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Abstract. Porcine circovirus type 2 (PCV2)-associated disease (PCVAD) continues to be an important differential diagnosis on pig farms in the United States and worldwide. Case trend analyses indicate that the incidence of PCVAD is on the rise in the United States. Accurate diagnosis is important in order to implement appropriate intervention strategies. PCVAD can manifest as a systemic disease, as part of the respiratory disease complex, as an enteric disease, as porcine dermatitis and nephropathy syndrome, or as reproductive problems. PCVAD may be only a sporadic individual animal diagnosis; however, PCVAD may also manifest as a severe herd problem accelerated and enhanced by concurrent virus or bacterial infections. This article is intended to discuss the most common disease manifestations, pathogenesis, diagnostic approaches, and intervention strategies associated with PCVAD in North America.

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“…In addition, the organs of 9 stillborn piglets and 2 preweaning piglets were analyzed by polymerase chain reaction (PCR) for pathogenic bacteria and viruses, such as PCV2 [5], PRRS virus (PRRSV) [3] and PPV [8], as described previously. Serum samples also were tested for the presence of PCV2, PRRSV and PPV antibodies by indirect immunofluorescence [5], an enzyme-linked immunosorbent assay (ELISA; IDEXX Laboratories KK, Tokyo, Japan) and a hemagglutination-inhibition test (Kyoto Biken Laboratories Inc., Kyoto, Japan), respectively.…”

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confidence: 99%

“…Serum samples also were tested for the presence of PCV2, PRRSV and PPV antibodies by indirect immunofluorescence [5], an enzyme-linked immunosorbent assay (ELISA; IDEXX Laboratories KK, Tokyo, Japan) and a hemagglutination-inhibition test (Kyoto Biken Laboratories Inc., Kyoto, Japan), respectively.…”

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confidence: 99%

Reproductive Losses Associated with Porcine Circovirus Type 2 in a Japanese Herd of Seronegative Sows

Togashi

Mawatari

Mitobe

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. From April to July 2009, there was a high rate of reproductive losses in a 30-sow, farrow-to-finish swine herd in Yamagata Prefecture, Japan. Histopathological examinations of heart tissue from stillborn and preweaning piglets showed nonsuppurative, necrotizing lesions. Immunohistochemical staining and polymerase chain reaction analysis of myocardial lesions revealed the presence of porcine circovirus type 2 (PCV2) antigens and DNA in these tissues. Indirect immunofluorescence also showed that the PCV2 antibody positive rate in the sows was higher in May 2009 than in December 2008. The results of this study suggest that PCV2 spread to this farm and caused a high rate of reproductive losses.

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Effects of Dexamethasone on the Pathogenesis of Porcine Circovirus Type 2 Infection in Piglets

Cited by 22 publications

References 28 publications

Thymic Granulomatous Lesions in Pigs

Thymic Granulomatous Lesions in Pigs

Porcine Circovirus Type 2–Associated Disease: Update on Current Terminology, Clinical Manifestations, Pathogenesis, Diagnosis, and Intervention Strategies

Reproductive Losses Associated with Porcine Circovirus Type 2 in a Japanese Herd of Seronegative Sows

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