Effects of dexamethasone and gamma globulin combined with prednisone on the therapeutic effect and immune function of Henoch‐Schonlein purpura nephritis in children

Abstract

Background Henoch‐Schonlein purpura nephritis (HSPN) is a serious complication of Henoch‐Schonlein purpura (HSP), which is usually treated with immunosuppressant and glucocorticoid. This study was designed to explore the effect of dexamethasone and gamma globulin combined with prednisone in the treatment of pediatric HSPN. Methods According to the treatment plan, 60 children treated with dexamethasone and gamma globulin were included in the control group, and the rest 55 children treated with dexamethasone and gamma globulin combined with prednisone were selected as the research group. The clinical manifestations, therapeutic effect, immune function, serum inflammatory factors, blood coagulation function, urine routine, renal function, and adverse reactions were compared between the two groups. Results The clinical manifestations of children in the research group were significantly better than those in the control group after treatment (P < .05). The total effective rate in the research group (94.55%) was markedly higher than that in the control group (76.67%) (P < .05). CD3+, CD4+, CD8+, IL‐10, PT, and APTT increased while CD4+/CD8+, IgA, IL‐8, TNF‐α, FIB, urine protein, urine red blood cell, Scr, and BUN decreased in both groups after treatment, and the changes of all the above indexes in the research group were significant than those in the control group (P < .05). The incidence of adverse reactions in the research group was remarkably superior to that in the control group (P < .05). Conclusion Dexamethasone and gamma globulin combined with prednisone can improve the immune function of children with HSPN and promote the recovery of renal function.

Recurrence of Henoch Schoenlein Purpura Nephritis in Children: A Retrospective Study

“…This finding is in line with several studies in which relapses occurred more frequently in children treated with an adjunctive steroid therapy [ 21 , 22 ]. Contrastingly, in Chen L et al study, corticosteroids improved the immune function of children with HSPN and promoted the recovery of renal function [ 23 ].In the same line, Hou et al successfully treated patients with HSPN by administering corticosteroid in combination with leflunomide therapy [ 24 ].Our controversial finding highlights the recommendation to limit the use of steroids to a carefully selected group of HSPN children, even though corticosteroids may alleviate the symptoms.…”

Application of intelligent nursing based on cloud computing of internet of things in children with pneumonia and sepsis treated with human gamma globulin

“…It is enriched with various antibodies in the serum of healthy people, and a direct intravenous infusion of HGG boost the immune system of the child in the short term, and in combination with antibiotics can enhance the combined effect of anti-infective treatment. 4,5 However, HGG administration may cause a variety of adverse events and there is little experience with this drug in children and febrile patients. 6 Therefore, the use of this adjunctive therapy in pediatric patients with pneumonia sepsis requires close supervision.…”