Effects of developmental exposure to bisphenol A and ethinyl estradiol on spatial navigational learning and memory in painted turtles (Chrysemys picta)

Manshack, Lindsey K.; Conard, Caroline M.; Johnson, Sarah A.; Alex, Jorden M.; Bryan, Sara J.; Deem, Sharon L.; Holliday, Dawn K.; Ellersieck, Mark R.; Rosenfeld, Cheryl S.

doi:10.1016/j.yhbeh.2016.07.009

Cited by 15 publications

(10 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Painted turtles ( Chrysemys picta ) also lack sex chromosomes and demonstrate TSD. When we exposed painted turtles eggs that were incubated at the male producing temperature (MPT) to the endocrine disrupting chemical, bisphenol A (BPA), it resulted in partial gonadal sex reversal to female, feminized their behavioral responses, and altered brain gene expression patterns, especially for transcripts associated with mitochondrial and ribosomal function relative to control males (Jandegian et al, 2015 ; Manshack et al, 2016 , 2017 ).…”

Section: Brain Sexual Differentiation In Example Fish and Reptilian Smentioning

confidence: 99%

Brain Sexual Differentiation and Requirement of SRY: Why or Why Not?

Rosenfeld

2017

Front. Neurosci.

Self Cite

View full text Add to dashboard Cite

Brain sexual differentiation is orchestrated by precise coordination of sex steroid hormones. In some species, programming of select male brain regions is dependent upon aromatization of testosterone to estrogen. In mammals, these hormones surge during the organizational and activational periods that occur during perinatal development and adulthood, respectively. In various fish and reptiles, incubation temperature during a critical embryonic period results in male or female sexual differentiation, but this can be overridden in males by early exposure to estrogenic chemicals. Testes development in mammals requires a Y chromosome and testis determining gene SRY (in humans)/Sry (all other therian mammals), although there are notable exceptions. Two species of spiny rats: Amami spiny rat (Tokudaia osimensis) and Tokunoshima spiny rat (Tokudaia tokunoshimensis) and two species of mole voles (Ellobius lutescens and Ellobius tancrei), lack a Y chromosome/Sry and possess an XO chromosome system in both sexes. Such rodent species, prototherians (monotremes, who also lack Sry), and fish and reptile species that demonstrate temperature sex determination (TSD) seemingly call into question the requirement of Sry for brain sexual differentiation. This review will consider brain regions expressing SRY/Sry in humans and rodents, respectively, and potential roles of SRY/Sry in the brain will be discussed. The evidence from various taxa disputing the requirement of Sry for brain sexual differentiation in mammals (therians and prototherians) and certain fish and reptilian species will be examined. A comparative approach to address this question may elucidate other genes, pathways, and epigenetic modifications stimulating brain sexual differentiation in vertebrate species, including humans.

show abstract

Section: Brain Sexual Differentiation In Example Fish and Reptilian Smentioning

confidence: 99%

Brain Sexual Differentiation and Requirement of SRY: Why or Why Not?

Rosenfeld

2017

Front. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, it is also becoming apparent that exposure to BPA, especially during development, can result in neurobehavioral and other disorders [2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14]. Examples of neurobehavioral disorders that have been associated with BPA in rodent and other animal models include cognitive deficits, increased anxiety, socio-sexual deficiencies, compromised maternal and/or paternal care, and decreased voluntary physical activity [15; 16; 17; 18; 19; 20; 21; 22; 23]. Evidence also links exposure to this chemical to neurological disorders, such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) [2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 24; 25; 26; 27].…”

Section: Introductionmentioning

confidence: 99%

Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues

Rosenfeld

2017

Frontiers in Neuroendocrinology

Self Cite

View full text Add to dashboard Cite

Animal and human studies provide evidence that exposure to the endocrine disrupting chemical (EDC), bisphenol A (BPA), can lead to neurobehavioral disorders. Consequently, there is an impetus to identify safer alternatives to BPA. Three bisphenol compounds proposed as potential safer alternatives to BPA are bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF). However, it is not clear whether these other compounds are safer in terms of inducing less endocrine disrupting effects in animals and humans who are now increasingly coming into contact with these BPA-substitutes. In the past few years, several animal studies have shown exposure to these other bisphenols induce similar neurobehavioral disruption as BPA. We will explore in this review article the current studies suggesting these other bisphenols result in neuroendocrine disruptions that may be estrogen receptor-dependent. Current work may aide in designing future studies to test further whether these BPA-substitutes can act as neuroendocrine disruptors.

show abstract

“…In other studies examining neurobehavioral disruptions induced by developmental exposure to BPA and EE in California mice, deer mice ( P . maniculatus bairdii ), Sprague-Dawley rats, and painted turtles ( Chrysemys picta ), we have found that these EDCs do not always induce similar gene expression changes in the brain or behavioral alterations [ 29 , 32 – 36 , 61 , 62 ]. Thus, the current data suggest that EE may not be the ideal positive control for BPA developmental exposure studies and other steroidogenic compounds, such as androgens, should possibly be tested as well.…”

Section: Discussionmentioning

confidence: 99%

Multigenerational effects of bisphenol A or ethinyl estradiol exposure on F2 California mice (Peromyscus californicus) pup vocalizations

et al. 2018

Self Cite

View full text Add to dashboard Cite

Rodent pups use vocalizations to communicate with one or both parents in biparental species, such as California mice (Peromyscus californicus). Previous studies have shown California mice developmentally exposed to endocrine disrupting chemicals, bisphenol A (BPA) or ethinyl estradiol (EE), demonstrate later compromised parental behaviors. Reductions in F1 parental behaviors might also be due to decreased emissions of F2 pup vocalizations. Thus, vocalizations of F2 male and female California mice pups born to F1 parents developmentally exposed to BPA, EE, or controls were examined. Postnatal days (PND) 2–4 were considered early postnatal period, PND 7 and 14 were defined as mid-postnatal period, and PND 21 and 28 were classified as late postnatal period. EE pups showed increased latency to emit the first syllable compared to controls. BPA female pups had decreased syllable duration compared to control and EE female pups during the early postnatal period but enhanced responses compared to controls at late postnatal period; whereas, male BPA and EE pups showed greater syllable duration compared to controls during early postnatal period. In mid-postnatal period, F2 BPA and EE pups emitted greater number of phrases than F2 control pups. Results indicate aspects of vocalizations were disrupted in F2 pups born to F1 parents developmentally exposed to BPA or EE, but their responses were not always identical, suggesting BPA might not activate estrogen receptors to the same extent as EE. Changes in vocalization patterns by F2 pups may be due to multigenerational exposure to BPA or EE and/or reduced parental care received.

show abstract

Effects of developmental exposure to bisphenol A and ethinyl estradiol on spatial navigational learning and memory in painted turtles (Chrysemys picta)

Cited by 15 publications

References 73 publications

Brain Sexual Differentiation and Requirement of SRY: Why or Why Not?

Brain Sexual Differentiation and Requirement of SRY: Why or Why Not?

Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues

Multigenerational effects of bisphenol A or ethinyl estradiol exposure on F2 California mice (Peromyscus californicus) pup vocalizations

Contact Info

Product

Resources

About