Effects of desloratadine citrate disodium injection on rat models of ovalbumin‐induced allergic rhinitis: involvement of T‐cell responses modulation

Yuan, Xin; Ghosh, Arijit; Jie, Qiong; He, Guangwei; Wu, Yafang

doi:10.1002/alr.21594

Cited by 8 publications

(6 citation statements)

References 37 publications

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“…17 As we know, the immune system is a sensitive target for toxicologic factors in environment. 18 A perfect balance of Th1 and Th2 response is essential to a normal immune response. Th2 immunoresponse is the main mechanism for AR.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ursolic Acid on the Expression of Th1–Th2-related Cytokines in a Rat Model of Allergic Rhinitis After PM2.5 Exposure

Sun

Han

Wang

et al. 2020

Am J Rhinol�Allergy

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Background Allergic rhinitis (AR) is a global health problem and closely related to environmental factors. Ursolic acid (UA) has potential in the treatment of allergic inflammation. The effects of UA intervention on PM2.5-induced AR remain uncertain. Objective To assess the effects of UA on nasal symptoms and the expression of T-helper (Th)1–Th2-related cytokines in a rat model of AR after fine particulate matter (particulate matter ≤ 2.5 µm [PM2.5]) exposure. Methods A total of 40 healthy female Sprague-Dawley rats were randomly divided into 4 groups: normal control group (NC group), ovalbumin (OVA)- induced AR model (AR group), PM2.5-exposed AR group exposed to 200 g/m3 PM2.5 for 30 days via inhalation (ARE group), and a group with UA intervention to the AR model after PM2.5 exposure (UA group). UA intervention was adopted after PM2.5 exposure in the UA group. Nasal symptoms and levels of Th1–Th2 cytokines in the serum were detected in each individual rat. The pathological changes and expression of Eotaxin in the nasal mucosa of each individual rat were examined by histology. Results PM2.5 significantly increased the number of sneezes and nasal rubs in the rats with AR, and UA alleviated these symptoms. UA decreased interleukin (IL)-4, IL-5, IL-13, Eotaxin-1, and OVA Immunoglobulin E (IgE) protein levels. In the AR group, hematoxylin and eosin staining showed disordered arrangement of the nasal mucosa epithelium, cell shedding, eosinophilic infiltration, swelling of the glands, and submucosal vascular congestion. UA group showed reduced eosinophilic infiltration and orderly arrangement of the mucosal epithelium when compared with the ARE group. Immunohistochemical results showed that the expression of Eotaxin in the UA group was lower than that in the ARE group. Conclusion UA could relieve nasal symptoms caused by PM2.5 exposure, the possible mechanism of which is to inhibit the expression of Th2 cytokines, eosinophilic infiltration, and specific IgE production.

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Section: Discussionmentioning

confidence: 99%

Effects of Ursolic Acid on the Expression of Th1–Th2-related Cytokines in a Rat Model of Allergic Rhinitis After PM2.5 Exposure

Sun

Han

Wang

et al. 2020

Am J Rhinol�Allergy

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“…Pharmacological pharmacokinetic studies have shown that it has higher solubility than other second-generation antihistamines with better safety, so it may have better efficacy for the treatment of chronic urticaria. 7,8 Currently, there are few studies on the effects of desloratadine citrate disodium on serum immunological function indices (IgE, C3 and C4), inflammatory factors (IL-4, IL-17 and IL-33), and chemokines (MCP-1, RANTES and Eotaxin) in patients with chronic urticaria.…”

Section: Introductionmentioning

confidence: 99%

Effects of Desloratadine Citrate Disodium on Serum Immune Function Indices, Inflammatory Factors and Chemokines in Patients with Chronic Urticaria

Wang

Zhao

Yan

2019

J Coll Physicians Surg Pak

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were selected as study subjects. Inclusion criteria were clinically diagnosed as chronic urticaria, with symptoms and signs of urticaria 24 hours before the experiment; and no other antihistamines, anticholinergic agents, receptor agonists, aspirin drugs or glucocorticoids taken within 2 weeks. Exclusion criteria were pregnant women, lactating women, women of childbearing age who planned to have children in the near future;

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“…Remodeling occurs in all inflammatory responses, and the mechanism and severity vary, depending on the disease. 8 Th2 immune response and air-way remodeling are well-known mechanisms responsible for AR 9,10 ; however, little is known regarding how PM2.5 exposure affects Th2related cytokines and the extent of nasal remodeling in AR.…”

mentioning

confidence: 99%

T-Helper Type 1-T-Helper Type 2 Shift and Nasal Remodeling after Fine Particulate Matter Exposure in a Rat Model of Allergic Rhinitis

Dong

Hong

et al. 2017

Am J Rhinol�Allergy

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Effects of desloratadine citrate disodium injection on rat models of ovalbumin‐induced allergic rhinitis: involvement of T‐cell responses modulation

Abstract: DLC (i.v.), given after an allergen challenge, improved Th1 cytokines level and restrained Th2 responses alleviating the symptoms of AR. Our results indicate that DLC injection may exhibit such effects through the modulation of T-cell responses.

Cited by 8 publications

References 37 publications

Effects of Ursolic Acid on the Expression of Th1–Th2-related Cytokines in a Rat Model of Allergic Rhinitis After PM2.5 Exposure

Effects of Ursolic Acid on the Expression of Th1–Th2-related Cytokines in a Rat Model of Allergic Rhinitis After PM2.5 Exposure

Effects of Desloratadine Citrate Disodium on Serum Immune Function Indices, Inflammatory Factors and Chemokines in Patients with Chronic Urticaria

T-Helper Type 1-T-Helper Type 2 Shift and Nasal Remodeling after Fine Particulate Matter Exposure in a Rat Model of Allergic Rhinitis

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