Effects of desipramine and alprazolam in the forced swim test in rats after long-lasting termination of chronic exposure to picrotoxin and pentylenetetrazol

G, Cannizzaro; Flugý, A.; Cannizzaro, Carla; Gagliano, M.; Simonetti, Michele

doi:10.1016/0924-977x(93)90272-n

Cited by 19 publications

(8 citation statements)

References 36 publications

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“…It is also possible that the elevated anxiety observed in the HSPP-H withdrawal group could contribute to the altered behavior in the FST. This is supported by previous studies demonstrating that agents that increase anxiety, including pentylenetetrazol, a corticotropin-releasing factor receptor type 1 (CRF1) agonist, or a diazepam inverse agonist, all decrease immobility time in the FST, similar to the effects observed in the present study (31)(32)(33). In addition, exposure to stress produces a state where subsequent antidepressant treatment increases, instead of decreases, immobility (34).…”

Section: Behavioral Studiessupporting

confidence: 78%

A Postpartum Model in Rat: Behavioral and Gene Expression Changes Induced by Ovarian Steroid Deprivation

Suda

Segi-Nishida

Newton

et al. 2008

Biological Psychiatry

136

103

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Background-Postpartum depression (PPD) affects approximately 10% to 20% of women during the first 4 weeks of the postpartum period and is characterized by labile mood with prominent anxiety and irritability, insomnia,and depressive mood. During the postpartum period, elevated ovarian hormones abruptly decrease to the early follicular phase levels that are postulated to play a major role in triggering PPD. However, the underlying neurobiological mechanisms that contribute to PPD have not been determined.

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Section: Behavioral Studiessupporting

confidence: 78%

A Postpartum Model in Rat: Behavioral and Gene Expression Changes Induced by Ovarian Steroid Deprivation

Suda

Segi-Nishida

Newton

et al. 2008

Biological Psychiatry

136

103

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“…Cannizzaro et al [36], Sabatino et al [37], Helfer et al [38], Ma and Leung [39], Witnick et al [40], did not find changes in FST and in taste preference in the animals kindled with either pentylenetetrazole, or amygdala stimulation. In contrast, Mortazavi et al [41] found that pentylenetetrazole-kindled animals showed increased immobility time in FST.…”

Section: Discussionmentioning

confidence: 94%

Kindling epileptogenesis in immature rats leads to persistent depressive behavior

Mazarati¹,

Shin²,

Auvin³

et al. 2007

Epilepsy & Behavior

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Depression is a frequent comorbidity in epilepsy patients. A variety of biological factors may underlie epilepsy-associated depression. We examined whether kindling-induced chronic increase in seizure susceptibility is accompanied by behavioral symptoms of depression. Three week-old Wistar rats underwent rapid kindling -84 initially subconvulsant electrical stimulations of ventral hippocampus delivered every five minutes -followed by depression-specific behavioral tests performed two and four weeks later. Kindled animals exhibited sustained increase in the immobility time in the forced swim test and the loss of taste preference towards calorie-free saccharin, as compared to controls. Initial loss of preference towards the intake of calorie-containing sucrose was followed by the increased consumption at four weeks. At both time points, animals exhibited enhanced seizure susceptibility upon test stimulations of the hippocampus. We conclude that neuronal plastic changes associated with kindling state are accompanied by the development of depressive behavior.

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“…Since PDE4BÀ/À mice displayed anxiety-like behavior, it is possible that the 'antidepressant-like' effect in the FST resulted from anxiety-related struggling, leading to decreased immobility. This is supported by studies showing that treatment causing anxiogenic-like effects (eg acute pentylenetetrazol or the CRF1 agonist cortagine) results in antidepressant-like behavior in the FST (Cannizzaro et al, 1993;Tezval et al, 2004). Therefore, the 'antidepressant-like' effect of PDE4BÀ/À mice observed in the FST may be a 'false positive' result.…”

Section: Pde4b-deficiency and Behavior H-t Zhang Et Almentioning

confidence: 90%

“…They also showed a slight but significant increase in hippocampal neurogenesis. The behavioral pattern of the anxiogenic-like effect and reduced immobility in the FST observed in PDE4BÀ/À mice appears not uncommon; it also occurs in BDNF transgenic mice (Govindarajan et al, 2006) and in rats treated acutely with pentylenetetrazol (Cannizzaro et al, 1993) or fluoxetine (Zienowicz et al, 2006). Thus, the present data suggest that PDE4B plays a role in the anxiogenic-like effects of acute rolipram (Heaslip and Evans, 1995;Imaizumi et al, 1994), which also exerts antidepressant activity.…”

Section: Pde4b-deficiency and Behavior H-t Zhang Et Almentioning

confidence: 99%

Anxiogenic-Like Behavioral Phenotype of Mice Deficient in Phosphodiesterase 4B (PDE4B)

Zhang

Huang

Masood

et al. 2007

Neuropsychopharmacol

157

143

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Phosphodiesterase-4 (PDE4), an enzyme that catalyzes the hydrolysis of cyclic AMP and plays a critical role in controlling its intracellular concentration, has been implicated in depression-and anxiety-like behaviors. However, the functions of the four PDE4 subfamilies (PDE4A, PDE4B, PDE4C, and PDE4D) remain largely unknown. In animal tests sensitive to anxiolytics, antidepressants, memory enhancers, or analgesics, we examined the behavioral phenotype of mice deficient in PDE4B (PDE4BÀ/À). Immunoblot analysis revealed loss of PDE4B expression in the cerebral cortex and amygdala of PDE4BÀ/À mice. The reduction of PDE4B expression was accompanied by decreases in PDE4 activity in the brain regions of PDE4BÀ/À mice. Compared to PDE4B + / + littermates, PDE4BÀ/À mice displayed anxiogenic-like behavior, as evidenced by decreased head-dips and time spent in head-dipping in the holeboard test, reduced transitions and time on the light side in the light-dark transition test, and decreased initial exploration and rears in the open-field test. Consistent with anxiogenic-like behavior, PDE4BÀ/À mice displayed increased levels of plasma corticosterone. In addition, these mice also showed a modest increase in the proliferation of neuronal cells in the hippocampal dentate gyrus. In the forced-swim test, PDE4BÀ/À mice exhibited decreased immobility; however, this was not supported by the results from the tail-suspension test. PDE4BÀ/À mice did not display changes in memory, locomotor activity, or nociceptive responses. Taken together, these results suggest that the PDE4B subfamily is involved in signaling pathways that contribute to anxiogenic-like effects on behavior.

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Effects of desipramine and alprazolam in the forced swim test in rats after long-lasting termination of chronic exposure to picrotoxin and pentylenetetrazol

Cited by 19 publications

References 36 publications

A Postpartum Model in Rat: Behavioral and Gene Expression Changes Induced by Ovarian Steroid Deprivation

A Postpartum Model in Rat: Behavioral and Gene Expression Changes Induced by Ovarian Steroid Deprivation

Kindling epileptogenesis in immature rats leads to persistent depressive behavior

Anxiogenic-Like Behavioral Phenotype of Mice Deficient in Phosphodiesterase 4B (PDE4B)

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