Effects of depressive and anxious symptoms on norepinephrine and platelet P-selectin responses to acute psychological stress among elderly caregivers

Aschbacher, Kirstin; Mills, Paul J.; Känel, Roland von; Hong, Suzi; Mausbach, Brent T.; Roepke, Susan K.; Dimsdale, Joel E.; Patterson, Thomas L.; Ziegler, Michael G.; Ancoli‐Israel, Sonia; Grant, Igor

doi:10.1016/j.bbi.2007.10.002

Cited by 79 publications

(58 citation statements)

References 92 publications

(112 reference statements)

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“…The transient nature of the genetic effects of chronic heterotypic stress in our study is consistent with clinical observations that the symptoms of IBS improve with the resolution of major life stressors (13,41,57). It is noteworthy that the plasma and urine levels of norepinephrine are elevated in IBS, as well as in chronically stressed subjects (2,17,28,37).…”

Section: Discussionsupporting

confidence: 92%

Norepinephrine mediates the transcriptional effects of heterotypic chronic stress on colonic motor function

Choudhury¹,

Shi²,

Sarna³

2009

American Journal of Physiology-Gastrointestinal and Liver Physi

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Chronic stress precipitates or exacerbates the symptoms of functional bowel disorders, including motility dysfunction. The cellular mechanisms of these effects are not understood. We tested the hypothesis that heterotypic chronic stress (HeCS) elevates the release of norepinephrine from the adrenal medulla, which enhances transcription of the gene-regulating expression of Ca(v)1.2 (L-type) channels in colonic circular smooth muscle cells, resulting in enhanced colonic motor function. The experiments were performed in rats using a 9-day heterotypic chronic stress (HeCS) protocol. We found that HeCS, but not acute stress, time dependently enhances the contractile response to ACh in colonic circular smooth muscle strips and in single dissociated smooth muscle cells, the plasma levels of norepinephrine and the mRNA and protein expressions of the alpha(1C) subunit of Ca(v)1.2 channels. These effects result in faster colonic transit and increase in defecation rate. The effects of HeCS are blocked by adrenalectomy but not by depletion of norepinephrine in sympathetic neurons. The inhibition of receptors for glucocortocoids, corticotropin-releasing hormone or nicotine also does not block the effects of heterotypic chronic stress. Norepinephrine acts on alpha- and beta(3)-adrenergic receptors to induce the transcription of alpha(1C) subunit. We conclude that HeCS alters colonic motor function by elevating the plasma levels of norepinephrine. Colonic motor dysfunction is associated with enhanced gene transcription of Ca(v)1.2 channels in circular smooth muscle cells. These findings suggest the potential cellular mechanisms by which heterotypic chronic stress may exacerbate motility dysfunction in patients with irritable bowel syndrome.

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Section: Discussionsupporting

confidence: 92%

Norepinephrine mediates the transcriptional effects of heterotypic chronic stress on colonic motor function

Choudhury¹,

Shi²,

Sarna³

2009

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…These effects include a greater risk for depression (3–9), anxiety (3, 10), physical morbidity (3), mortality (11, 12), and obesity (13). Caregiver status is also associated with poorer sleep quality (14), increased levels of stress hormones (15–18), reduced immune function (15, 17, 19), slower wound healing (20), new cases of hypertension (21), and new cases of coronary heart disease (22–24). Recent research has additionally linked the depression often experienced by ADRD caregivers with an increased incidence of emergency department visits (25).…”

Section: Introductionmentioning

confidence: 99%

Video-Based Coping Skills to Reduce Health Risk and Improve Psychological and Physical Well-Being in Alzheimer's Disease Family Caregivers

Williams

Bishop-Fitzpatrick

Lane

et al. 2010

Psychosomatic Medicine

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Objective-To determine whether video-based coping skills (VCS) training with telephone coaching reduces psychosocial and biological markers of distress in primary caregivers of a relative with Alzheimer's Disease or related dementia (ADRD) Methods-A controlled clinical trial was conducted with 116 ADRD caregivers who were assigned, alternately as they qualified for the study, to a Wait List control condition or the VCS training arm in which they viewed two modules/week of a version of the Williams LifeSkills Video adapted for ADRD family care contexts, did the exercises and homework for each module presented in an accompanying Workbook, and received one telephone coaching call per week for five weeks on each week's two modules. Questionnaire-assessed depressive symptoms, state and trait anger and anxiety, perceived stress, hostility, caregiver self-efficacy, salivary cortisol across the day and before and after a stress protocol, and blood pressure and heart rate during a stress protocol were assessed prior to VCS training, seven weeks after training was completed and at three and six months follow-up.Results-Compared to controls, participants who received VCS training plus telephone coaching showed significantly greater improvements in depressive symptoms, trait anxiety, perceived stress, and average systolic and diastolic blood pressure that were maintained over the six-month followup period.Conclusions-VCS training augmented by telephone coaching reduced psychosocial and biological indicators of distress in ADRD caregivers. Future studies should determine the longterm benefits to mental and physical health from this intervention.

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“…Serotonin, CD40L and PECAM-1 levels correlated negatively with the results of the LTE-Q. This might be due to the fact that chronic life stress sensitizes towards additional stressors, possibly representing an adaptive process to continuing challenges [50].…”

Section: Accepted Manuscriptmentioning

confidence: 98%

Differential changes in platelet reactivity induced by acute physical compared to persistent mental stress

Hüfner

Koudouovoh-Tripp

Kandler

et al. 2015

Physiology & Behavior

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Effects of depressive and anxious symptoms on norepinephrine and platelet P-selectin responses to acute psychological stress among elderly caregivers

Cited by 79 publications

References 92 publications

Norepinephrine mediates the transcriptional effects of heterotypic chronic stress on colonic motor function

Norepinephrine mediates the transcriptional effects of heterotypic chronic stress on colonic motor function

Video-Based Coping Skills to Reduce Health Risk and Improve Psychological and Physical Well-Being in Alzheimer's Disease Family Caregivers

Differential changes in platelet reactivity induced by acute physical compared to persistent mental stress

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