Effects of Dementia on Mortality in the Radiation Effects Research Foundation Adult Health Study

Yamada, Michiko; Kasagi, Fumiyoshi; Sasaki, Hideo; Mimori, Yasuyo; Suzuki, Gen

doi:10.1159/000075562

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…Small sample sizes [4,8,11] , the use of death certifi cates to ascertain dementia [7] , an exclusive focus on AD cases [4,8,9] , and non-representative study populations [6,9,13,14] restrict the breadth of possible inference and limit the interpretability of results to date. The present study makes use of comprehensive longitudinal data on community-dwelling and institutionalized seniors from the Canadian Study of Health and Aging (CSHA) to identify the leading reported underlying causes of death (UCD) among elderly demented and in relation to non-demented subjects.…”

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confidence: 99%

Underlying Cause of Death in Demented and Non-Demented Elderly Canadians

Chamandy¹,

Wolfson

2005

Neuroepidemiology

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This paper examines the associations between clinical dementia and underlying cause of death (UCD) in a population-based sample of seniors who took part in the Canadian Study of Health and Aging (CSHA). Cause-of-death data were obtained via death certificates for 2,924 of 2,982 deceased subjects. Among the decedents were 823 clinically demented and 670 clinically non-demented participants. Using logistic regression we examined factors associated with a particular UCD in the overall group and also in the subgroup of demented seniors. Dementia was found to be associated with an increased risk of death from pneumonia. Both Alzheimer’s disease and vascular dementia appear to decrease the risk of mortality from neoplasm. To our knowledge, this study is the first of its kind that combines a large, representative sample with thorough clinical assessment of cognitive status.

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confidence: 99%

Underlying Cause of Death in Demented and Non-Demented Elderly Canadians

Chamandy¹,

Wolfson

2005

Neuroepidemiology

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“…Through a PubMed literature review focused on dementia excess mortality and relative risk spanning 1980 to 2018, we identified 4470 total hits, of which 34 studies were marked for extraction (additional details in supporting information) 23–56 . The data sources included clinical or community‐based cohorts and excluded studies conducted solely in nursing homes.…”

Section: Methodsmentioning

confidence: 99%

Global mortality from dementia: Application of a new method and results from the Global Burden of Disease Study 2019

Nichols¹,

Abd‐Allah²,

Abdoli³

et al. 2021

A&D Transl Res & Clin Interv

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Introduction Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods We meta‐analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end‐stage disease to calculate the total number of deaths that could be attributed to dementia. Results We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41–4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27–2.71]) than men (0.56 million [0.14–1.51]), largely but not entirely due to the higher life expectancy in women (age‐standardized female‐to‐male ratio 1.19 [1.10–1.26]). Due to population aging, there was a large increase in all‐age mortality rates from dementia between 1990 and 2019 (100.1% [89.1–117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally.

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“…1 Several community-based studies have specifically investigated mortality in dementia and reported an increased risk of death in demented compared with nondemented subjects. [2][3][4][5][6] However, few studies have utilized a validated neuropsychological battery to ascertain "caseness" of dementia or mild cognitive impairment in the community setting. Even fewer studies have examined the effect of less-severe cognitive disorders, such as mild cognitive impairment, on mortality risk in a community setting.…”

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confidence: 99%

Level of Cognitive Impairment Predicts Mortality in High-Risk Community Samples: The Memory and Medical Care Study

Lee¹,

Kasper²,

Shore³

et al. 2006

JNP

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Over the course of 3 years, the authors investigated the relationship between severity of cognitive impairment and mortality in a community sample of 498 elders at high risk for cognitive impairment. Subjects were classified as having no cognitive disorder, mild cognitive impairment, or dementia, based on a validated battery of four neuropsychological tests. Severity of impairment was based on Mini-Mental State Examination scores. Additional data were obtained from subjects' knowledgeable informants and Medicare records. Kaplan-Meier survival estimates and Cox hazard proportion analysis of the sample revealed that presence of cognitive impairment increases mortality in a fashion that parallels the severity of the impairment.

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Effects of Dementia on Mortality in the Radiation Effects Research Foundation Adult Health Study

Cited by 5 publications

References 11 publications

Underlying Cause of Death in Demented and Non-Demented Elderly Canadians

Underlying Cause of Death in Demented and Non-Demented Elderly Canadians

Global mortality from dementia: Application of a new method and results from the Global Burden of Disease Study 2019

Level of Cognitive Impairment Predicts Mortality in High-Risk Community Samples: The Memory and Medical Care Study

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