Effects of deltamethrin on hepatic microsomal cytochrome p450‐dependent monooxygenases in carp

Deér, K. Aranka; Banka, L.; Nemcsók, J.; Ábrahám, Magdolna

doi:10.1080/03601239609373030

Cited by 11 publications

(7 citation statements)

References 16 publications

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“…The effects of deltamethrin on acetylcholineesterase (AChE) and some biochemical parameters such as glutamic oxaloacetic transaminase (GOT), lactate dehydrogenase (LDH) and glucose in different tissues of adult Cyprinus carpio were studied by Balint et al (1995) who have reported inhibition of AChE with the increase in GOT and LDH activities along with increase in blood glucose level. Inhibitory effect of deltamethrin at concentrations above 2 lg/L on the monooxygenase system of carp liver (Cyprinus carpio L.) was reported by Deer et al (1996). Kumar et al (1999) studied the deltamethrin-induced hematological changes in Heteropneustes fossilis and found a significant increase of erythrocyte, leucocyte, lymphocyte, neutrophil count and a slight reduction in haemoglobin and monocytes.…”

Section: Biochemical and Hematological Alterationsmentioning

confidence: 94%

Synthetic pyrethroids (Type II) and freshwater fish culture: Perils and mitigations

Prusty¹,

Meena

Mohapatra

et al. 2015

Int Aquat Res

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As a new class of agricultural insecticides, synthetic pyrethroids are widely used to control insect pests. Synthetic pyrethroids have been shown to enter the aquatic environment from agricultural runoff or drift from aerial and ground-based spraying applications posing threat to fishes which are less tolerant to pesticides through direct exposure. These insecticides interfere with the sodium channel of the nervous system resulting in prolonged sodium tail current. Widespread application of these chemicals has warranted the attention of the ecologist to understand the impact of these chemicals on the aquatic environment. In this perspective, an updated account of toxicological evaluation of three type II synthetic pyrethroids, viz. deltamethrin, cypermethrin and fenvalerate in terms of their physico-chemical, metabolic, hematological, histological, behavioral and reproductive aspects with respect to the fishes has been presented which may be useful for policy makers, academics, environmental scientists and agricultural professionals needing ready access to this information. The aim of the present synoptic literature appraisal was to summarize the main effect of current use, type II synthetic pyrethroids (deltamethrin, cypermethrin and fenvalerate) on aquatic environment due to their persistence and accumulation. This article will focus on non-target organisms in inland fresh water environment with special reference to fin fishes and will critically evaluate the toxicity of these pyrethroids in terms of growth inhibition, metabolic disorders, neurotoxicity, reproductive failure, enzymatic dysfunction, haematological alterations, and tissue damages. The rationalized information in this milieu may be useful in ecological risk evaluation and human health management as fish serves as an important bio-indicator for aquatic systems health.

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Section: Biochemical and Hematological Alterationsmentioning

confidence: 94%

Synthetic pyrethroids (Type II) and freshwater fish culture: Perils and mitigations

Prusty¹,

Meena

Mohapatra

et al. 2015

Int Aquat Res

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“…Deltamethrin was inhibitory to the monooxygenase system of carp liver (Cyprinus carpio L.) at the higher concentration of 2 g/L. The low concentration of 0.2 g/L resulted in faster metabolism of deltamethrin and was evaluated as induction of hepatic microsomal cytochrome P450-dependent monooxygenases (Deér et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Acute toxicity, behavioral changes, and histopathological effects of deltamethrin on tissues (gills, liver, brain, spleen, kidney, muscle, skin) of Nile tilapia (Oreochromis niloticus L.) fingerlings

YILDIRIM

Benlı

Selvı

et al. 2006

Environmental Toxicology

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Deltamethrin, a synthetic pyrethroid contaminating aquatic ecosystems as a potential toxic pollutant, was investigated in the present study for acute toxicity. The purpose of this study was to evaluate LC(50) values of deltamethrin on Nile tilapia (Oreochromis niloticus L.) fingerlings and investigate histopathological responses of fish exposed to deltamethrin. The 48 h LC(50) value for Nile tilapia fingerlings was estimated as 4.85 microg/L using static test system. In addition, behavioral changes at each deltamethrin concentration were observed closely. All fish, exposed to 5 microg/L deltamethrin revealed severe morphological alterations in the gills and liver. In the gills hyperemia, fusion of secondary lamellae and telangiectasis were observed; whereas hydropic degenerations in liver were observed in all examined fish. The results are significant for reporting acute deltamethrin toxicity in terms of behavioral and histopathological changes: Deltamethrin is highly toxic to fingerlings.

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“…2 and 3c) and low micromolar concentration of DM towards CYP 1A isoenzymes [4] were proven in vitro. The crucial role of cytochrome P450-dependent monooxygenases in the metabolism of pyrethroids has been demonstrated by numerous studies [4,10,12,36]. Although, DM was found to be a strong enzyme inhibitor [e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Xenobiotics may undergo redox cycling via the cytochrome P450 system [10,23], and the involvement of the CYP 1A isoenzymes in the biotransformation of certain planar organic contaminants [24], pyrethroid pesticides [5,23], e.g. deltamethrin [12,36] has also been demonstrated. Elevated oxyradical production as a consequence of induction of cytochrome(s) P450 activities [10,23,32,35] may result in toxicological consequences as oxidative damage in the tissues [10,17,19], mutagenesis and carcinogenesis [32].…”

Section: Introductionmentioning

confidence: 99%

Influence of the polyphenolic tannic acid on the toxicity of the insecticide deltamethrin to fish. A comparative study examining both biochemical and cytopathological parameters

Varanka

Deér

Rojik

et al. 2002

Acta Biologica Hungarica

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Humics and pesticides are present in aquatic environment and the toxicological consequences of their chemical interaction is well studied. However, data concerning the mechanism of the biochemical action of humic-pesticide combinations are scarce, especially in vertebrates. Thus we have chosen to study the in vivo effects of the plant polyphenolic tannic acid and the pyrethroid insecticide deltamethrin [Decis] alone or in combination on hepatic xenobiotic-metabolizing enzyme activities and the associated redox-parameters in carp, as the complex assessment of these systems are regarded to serve as a relevant biomarker of environmental pollution. Stress effects and tissue damage were followed by determination of the plasma glucose level, the activities of plasma transaminases, and by electron microscopy. Tannic acid alone exerted weak prooxidant effect due to its marked antioxidant enzyme inhibitory activity. Deltamethrin, applied in a very low dose, induced oxyradical production in fish via activation of cytochrome P450 isozymes. This effect was promoted by the antioxidant enzyme inhibitory action of tannic acid, when the two chemicals were combined; however, the ultrastructural damage of the hepatocytes was reduced by the common cytoprotective capacity of the phenolic. Numerous humics are known to alter the toxicity of pesticides and their influence depends on their type and concentration. Therefore, our work taken together with other comparative studies may contribute to the assessment of the impact of humics in nature, especially in case of environmental pollution.

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Effects of deltamethrin on hepatic microsomal cytochrome p450‐dependent monooxygenases in carp

Cited by 11 publications

References 16 publications

Synthetic pyrethroids (Type II) and freshwater fish culture: Perils and mitigations

Synthetic pyrethroids (Type II) and freshwater fish culture: Perils and mitigations

Acute toxicity, behavioral changes, and histopathological effects of deltamethrin on tissues (gills, liver, brain, spleen, kidney, muscle, skin) of Nile tilapia (Oreochromis niloticus L.) fingerlings

Influence of the polyphenolic tannic acid on the toxicity of the insecticide deltamethrin to fish. A comparative study examining both biochemical and cytopathological parameters

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