Effects of delta sleep-inducing peptide on pre-and postsynaptic glutamate and postsynaptic GABA receptors in neurons of the cortex, hippocampus, and cerebellum in rats

Григорьев, В. В.; Ivanova, T. A.; Kustova, Elena; Petrova, L. N.; Serkova, T. P.; Bachurin, S. O.

doi:10.1007/s10517-006-0323-9

Cited by 9 publications

(4 citation statements)

References 7 publications

(7 reference statements)

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“…Another study has reported the ability of DSIP to block presynaptic NMDA receptors in the culture of neuronal cells of the rat cerebral cortex, as well as to reduce glutamate-or NMDA-stimulated uptake of Ca 2+ into synaptosomes [16]. An antihypoxic effect has been shown for DSIP in vitro, where it activated oxidative phosphorylation and increased the resistance of brain neurons to hypoxia [17].…”

Section: Discussionmentioning

confidence: 99%

DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion

et al. 2021

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A structural analogue of the DSIP, peptide KND, previously showed higher detoxification efficacy upon administration of the cytotoxic drug cisplatin, compared to DSIP. DSIP and KND were investigated using the model of acute myocardial infarction in male SD rats and the model of acute focal stroke in C57Bl/6 mice. A significant decrease in the myocardial infarction area was registered in KND-treated animals relative to saline-treated control animals (19.1 ± 7.3% versus 42.1 ± 9.2%). The brain infarction volume was significantly lower in animals intranasally treated with KND compared to the control saline-treated animals (7.4 ± 3.5% versus 12.2 ± 5.6%). Injection of KND in the first minute of reperfusion in the models of myocardial infarction and cerebral stroke reduced infarction of these organs, indicating a pronounced cardioprotective and neuroprotective effect of KND and potentiality for the treatment of ischemia-reperfusion injuries after transient ischemic attacks on the heart and brain, when administered during the reperfusion period. A preliminary pilot study using the model of myocardial infarction with the administration of DSIP during occlusion, and the model of cerebral stroke with the administration of KND during occlusion, resulted in 100% mortality in animals. Thus, in the case of ischemia-reperfusion injuries of the myocardium and the brain, use of these peptides is only possible during reperfusion.

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Section: Discussionmentioning

confidence: 99%

DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion

et al. 2021

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“…Thus, Sudakov and colleagues showed that DSIP-caused activation of neurons at the sensorimotor cortex, dorsal hippocampus, ventral thalamic nuclei, and lateral hypothalamus could be explained by its action on NMDA receptors of these structures [ 50 ]. Grigor’ev et al showed that DSIP potentiated GABA-activated currents in hippocampal and cerebellar neurons and blocked NMDA-activated potentiation in cortical and hippocampal neurons [ 51 ]. There are available data that DSIP improves mitochondrial respiratory activity.…”

Section: Discussionmentioning

confidence: 99%

Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke

et al. 2021

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Background and Objectives: Mutual effect of the preliminary and therapeutic intranasal treatment of SD rats with DSIP (8 days) on the outcome of focal stroke, induced with intraluminal middle cerebral occlusion (MCAO), was investigated. Materials and Methods: The groups were the following: MCAO + vehicle, MCAO + DSIP, and SHAM-operated. DSIP or vehicle was applied nasally 60 (±15) minutes prior to the occlusion and for 7 days after reperfusion at dose 120 µg/kg. The battery of behavioral tests was performed on 1, 3, 7, 14, and 21 days after MCAO. Motor coordination and balance and bilateral asymmetry were tested. At the end of the study, animals were euthanized, and their brains were perfused, serial cryoslices were made, and infarction volume in them was calculated. Results: Although brain infarction in DSIP-treated animals was smaller than in vehicle-treated animals, the difference was not significant. However, motor performance in the rotarod test significantly recovered in DSIP-treated animals. Conclusions: Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions.

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“…DSIP optimizes the excitation/inhibition relationship [36]. Namely, it potentiates GABA-activated currents in the hippocampal and cerebellar neurons in rats [37], which could be one of the major mechanisms of action in the model of lindane-induced seizures. On the other hand, Shandra et al [18] believe that the neuroprotective role of DSIP on NMDA receptors functions through the reduction of excitatory amino-acids and decrease of Ca 2+ influx.…”

Section: Discussionmentioning

confidence: 99%

Modulatory effects of delta sleep-inducing peptide in a lindane model of generalized seizures

Hrnčić¹,

Grubač²,

Šutulović³

et al. 2018

ARCH BIOL SCI BELGRA

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Effects of delta sleep-inducing peptide on pre-and postsynaptic glutamate and postsynaptic GABA receptors in neurons of the cortex, hippocampus, and cerebellum in rats

Cited by 9 publications

References 7 publications

DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion

DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion

Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke

Modulatory effects of delta sleep-inducing peptide in a lindane model of generalized seizures

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