Effects of Delphinidin in Anthocyanin on MDA-MB-231 Breast Cancer Cells

장혜연,; 이송희,; 안인정,; 이해님,; 김혜리,; 박영석,; 박병권,; 김병수,; 김상기,; 조성대,; 남정석,; 최창순,; 정지윤,

doi:10.3746/jkfn.2014.43.2.231

Cited by 4 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Delphinidin reduced tumor growth in xenografted mice. These findings suggest that delphinidin has the potential to be developed as a cancer prevention drug due to its growth inhibitory effects and activation of apoptosis in human breast cancer cells [ 83 ].…”

Section: Delphinidin and Anticancer Activitiesmentioning

confidence: 99%

Delphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives

Sharma

Choi

Kim

et al. 2021

IJMS

View full text Add to dashboard Cite

Until now, several studies have looked at the issue of anthocyanin and cancer, namely the preventive and inhibitory effects of anthocyanins, as well as the underlying molecular processes. However, no targeted review is available regarding the anticarcinogenic effects of delphinidin and its glycosides on various cancers and their plausible molecular mechanisms. Considerable evidence shows significant anticancer properties of delphinidin-rich preparations and delphinidin alone both in vitro and in vivo. This review covers the in vitro and preclinical implications of delphinidin-mediated cell protection and cancer prevention; thus, we strongly recommend that delphinidin-rich preparations be further investigated as potential functional food, dietary antioxidant supplements, and natural health products targeting specific chronic diseases, including cancer. In addition to in vitro investigations, future research should focus on more animal and human studies to determine the true potential of delphinidin.

show abstract

Section: Delphinidin and Anticancer Activitiesmentioning

confidence: 99%

Delphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives

Sharma

Choi

Kim

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

Anticancer potential of delphinidin and its derivatives: therapeutic and mechanistic insights

Iqbal,

Omara,

Kahwa

et al. 2024

Med Chem Res

View full text Add to dashboard Cite

Anthocyanins are water-soluble naturally occurring flavonoids present in fruits, flowers, leaves, and roots of fruit plants and vegetables. One of the important anthocyanidin components of red wine and berries is delphinidin (DP). This review provides an update on the potential of DP in cancer therapy, with a further understanding of the mechanisms involved. Delphinidin has been shown to elicit inhibitory effects on catabolizing enzymes of human granulocytes and parasites, TNF-induced COX-2 expression in mouse epidermal cells, and reduce oxidative stress. It also inhibited anchorage-independent growth and caused cell death in breast cancer cell lines. Delphinidin increased Nrf2 expression, increased HO-1 production, and promoted mRNA expression of mitochondrial biogenesis-related factors. Further, DP has anti-proliferative and pro-apoptotic effects in various cancer cell lines such as lung, breast, and ovarian cancer cells. The mTOR-related pathway is the most important signaling pathway in the activation of autophagy, and DP has been shown to exert its cytotoxic effects on cancer cell lines via activating protein kinases. Among DP derivatives, delphinidin-3-O-glucoside has the best anticancer activity because it is easily absorbed. However, the metabolism of DP and its bioavailability in biological systems need to be explored to fully understand its benefits.

show abstract

Semisynthesis of anthocyanins

Majhi,

Manickam

2024

Semisynthesis of Bioactive Compounds and Their Biological Activities

View full text Add to dashboard Cite

Effects of Delphinidin in Anthocyanin on MDA-MB-231 Breast Cancer Cells

Cited by 4 publications

References 16 publications

Delphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives

Delphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives

Anticancer potential of delphinidin and its derivatives: therapeutic and mechanistic insights

Semisynthesis of anthocyanins

Contact Info

Product

Resources

About