Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice

Abstract

These results obtained using knockout mice indicate that GluR2-containing AMPA receptors may be critical for learning about contextual stimuli relevant to food rewards, but not drug rewards. When the results are considered in relation to our previous findings with gria1 and gria2 knockout mice, they also raise questions about the CPP paradigm representing a model of conditioned reward over a conditioned approach interpretation. However, it would be important to confirm these findings with alternative approaches, should selective ligands become available.

AMPA-Receptor GluR1 Subunits are Involved in the Control Over Behavior by Cocaine-Paired Cues

“…This observation is consistent with our previous reports that the KO does not impair instrumental responding for a natural reward (Mead and Stephens 2003), or the development of a conditioned place preference for cocaine (Mead et al, 2005) and that pharmacological antagonists of AMPA receptors have little effect on cocaine self-administration (Jackson et al, 1998). However, recent studies have implied a role for GluR1 in cocaine's reinforcing effects, with virally mediated overexpression of GluR1 increasing the break point for cocaine under a progressive ratio schedule , and deletion of gria1 preventing the formation of a conditioned place preference to cocaine (Dong et al, 2004).…”

Involvement of the AMPA Receptor GluR-C Subunit in Alcohol-Seeking Behavior and Relapse

“…Thus, GluR-A overexpression in the shell of the nucleus accumbens was found not to influence cue-induced cocaine relapsing behavior (Sutton et al, 2003), and it is also known that the alcohol deprivation effect in GluR-A knock-out mice is not different from that of wild-type controls (Cowen et al, 2003). Moreover, conflicting findings regarding cocaine-induced place preference in GluR-A knock-out mice have been reported previously (Dong et al, 2004;Mead et al, 2005). The role of the GluR-B subunit in this regard has been less studied thus far, in part because of the multiple behavioral abnormalities displayed by GluR-B knock-out mice (Gerlai et al, 1998;Mead and Stephens, 2003b); however, they also show normal cocaineinduced, but not food-induced, place preference (Mead et al, 2005).…”

“…Moreover, conflicting findings regarding cocaine-induced place preference in GluR-A knock-out mice have been reported previously (Dong et al, 2004;Mead et al, 2005). The role of the GluR-B subunit in this regard has been less studied thus far, in part because of the multiple behavioral abnormalities displayed by GluR-B knock-out mice (Gerlai et al, 1998;Mead and Stephens, 2003b); however, they also show normal cocaineinduced, but not food-induced, place preference (Mead et al, 2005). Therefore, although there is an increasing interest in the possible role of AMPA receptor subunit composition in drug-seeking behavior (Self and Choi, 2004), this genotypephenotype correlation remains elusive and, indeed, similar consequences in relapsing behavior have been hypothesized after the genetic deletion of different AMPA receptor subunits (Mead and Stephens, 2003a,b).…”

Locomotor activating effects and addiction-like features of MDPV as assessed in preclinical studies: a review.

“…However, this inference is not uniquely accepted by the scientific community (Bardo and Bevins, 2000;Sanchis-Segura and Spanagel, 2006), and alternative interpretations have been proposed (Mead et al, 2005). Nevertheless, it is a fact that addictive drugs, in a certain dose range, have the ability to elicit this approach response towards the stimulus that have been paired with (Carbo-Gas et al, 2014;Braida et al, 2004).…”