Effects of Dehydroepiandrosterone Sulfate Upon Phenotype and in Vitro Functions of Dendritic Cells

Селедцова, Н. В.; Хонина, Н. А.; Тихонова, М. А.; Останин, А. А.; Пасман, Н. М.; Черных, Е. Р.

doi:10.15789/1563-0625-2007-6-589-596

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The stimulatory effect of DHEAS on the immune system that results in the activation of natural killer cells (NK cells) and Th1 cells is well-known [ 34 ]. We have also shown that DHEAS can induce the in vitro maturation and Th1-stimulating activity of DCs [ 35 ]. Therefore, we suggest that immune dysfunctions in pregnant women with increased levels of DHEAS could result from impaired immunological tolerance, and the reduction in the tolerogenic potential of DCs might be caused by elevated concentrations of DHEAS.…”

Section: Introductionmentioning

confidence: 99%

Elevated levels of dehydroepiandrosterone as a potential mechanism of dendritic cell impairment during pregnancy

et al. 2015

View full text Add to dashboard Cite

BackgroundThis study aimed to test the hypothesis that immune dysfunction and the increased risk of spontaneous abortion in pregnant women with hyperandrogenia (HA) are caused by the reduced tolerogenic potential of dendritic cells (DCs) that results from elevated levels of dehydroepiandrosterone sulfate (DHEAS).MethodsThe phenotypic and functional properties of monocyte-derived DCs generated from blood monocytes from non-pregnant women, women with a normal pregnancy, or pregnant women with HA, as well as the in vitro effects of DHEAS on DCs in healthy pregnant women were investigated.ResultsIn a normal pregnancy, DCs were shown to be immature and are characterized by a reduced number of CD83+ and CD25+ DCs, the ability to stimulate type 2 T cell responses and to induce T cell apoptosis. By contrast, DCs from pregnant women with HA had a mature phenotype, were able to stimulate both type 1 (IFN-γ) and type 2 (IL-4) T cell responses, and were characterized by lower B7-H1 expression and cytotoxic activity against CD8+ T cells. The addition of DHEAS to cultures of DCs from healthy pregnant women induced the maturation of DCs and increased their ability to activate type 1 T cell responses.ConclusionOur data demonstrated the reduction in the tolerogenic potential of DCs from pregnant women with HA, and revealed new mechanisms involved in the hormonal regulation of DCs mediated by DHEAS.

show abstract

Section: Introductionmentioning

confidence: 99%

Elevated levels of dehydroepiandrosterone as a potential mechanism of dendritic cell impairment during pregnancy

et al. 2015

View full text Add to dashboard Cite

show abstract

Contribution of Dehydroepiandrosterone Sulfate and Progesterone to In Vitro Regulation of Tolerogenic Activity of IFN-α-Induced Dendritic Cells

et al. 2011

Self Cite

View full text Add to dashboard Cite

Dehydroepiandrosterone sulfate and progesterone exhibited an immunomodulatory effect on the tolerogenic characteristics of IFN-α-induced dendritic cells. The hormone effects depended on the initial level of allostimulatory activity of dendritic cells in mixed lymphocyte culture. However, dehydroepiandrosterone sulfate significantly more often stimulated allostimulatory activity by attenuating the tolerogenic properties of dendritic cells, while progesterone potentiated their tolerogenic potential. The capacity of the hormones (dehydroepiandrosterone sulfate and progesterone) to attenuate tolerogenic activity of dendritic cells was associated with reduction of FasL expression on these cells, while the increase in tolerogenic activity was associated with the increase in the percentage of CD123(+) dendritic cells, and under conditions of modification with dehydroepiandrosterone sulfate it was associated with increased B7-H1 expression. Possible contribution of indolamine-2,3-dioxygenase and prostaglandin E2 to stimulation of tolerogenic characteristics of dendritic cells modified with dehydroepiandrosterone sulfate and progesterone, respectively, was demonstrated.

show abstract

Effects of Dehydroepiandrosterone Sulfate Upon Phenotype and in Vitro Functions of Dendritic Cells

Cited by 2 publications

References 0 publications

Elevated levels of dehydroepiandrosterone as a potential mechanism of dendritic cell impairment during pregnancy

Elevated levels of dehydroepiandrosterone as a potential mechanism of dendritic cell impairment during pregnancy

Contribution of Dehydroepiandrosterone Sulfate and Progesterone to In Vitro Regulation of Tolerogenic Activity of IFN-α-Induced Dendritic Cells

Contact Info

Product

Resources

About