Effects of dehydroepiandrosterone on growth performance, lipid metabolic hormones and parameters in broilers

Abstract

ABSTRACT:One hundred and eighty (180) day-old broiler chickens were used to investigate the effects of dehydroepiandrosterone (DHEA) on growth performance, carcass composition, and the serum concentrations of several lipid metabolic hormones and metabolic parameters (indicators). The broilers received the same basal diets, with DHEA added at 0 (control), 5 and 20 mg/kg feed. During the experimental period, broilers fed DHEA exhibited lower levels of triglycerides (TG), total serum cholesterol (TC), high density lipoprotein-cholesterol (HDL-C) and non-esterified fatty acids (NEFA) as compared to the control animals, but a marked increase in lipoprotein lipase (LPL) activity. Adding DHEA to the diet significantly decreased serum concentrations of thyroxine (T 4 ), serum free triiodothyronine (FT 3 ), and serum free thyroxine (FT 4 ), but significantly increased the serum leptin (LEP) and glucogon (GLU) levels in male broiler chickens. However, female broiler chickens showed pronounced differences in LEP, FT 3 and FT 4 only, while there were no differences in the other three metabolic hormones (T 3 , T 4 and GLU). Overall, these results indicate that DHEA improves lipid metabolism through the regulation of metabolic hormones and metabolic parameters, while not adversely affecting growth performance in broiler chickens.

Effects of Dehydroepiandrosterone on Gross Morphology and Behavior of Perimenopausal Rats

“…This observation in in line with previous studies, which reported that DHEA administration reduce body weight gain (Shepherd and Cleary, 1984;Cleary and Zisk, 1986;Cleary, 1991;Svec et al, 1995;Abadie et al, 2000;Zhao et al, 2007;Ma et al, 2008;Hakkak et al, 2010Hakkak et al, & 2017. The decrease in body weight gain may be related to the decrease in food intake (Weindruch et al, 1984), or related to the decrease the abdominal or body fats (Cleary and Zisk, 1986;Villareal and Holloszy, 2004;Ma et al, 2008). However, other studies reported that DHEA treatment causes a decrease in the body weight (Tagliaferro et al, 1986;Mohan et al, 1990;Yamada et al, 1991;Han et al, 1998;Ng et al, 1999;Richards et al, 2000;Kopplow et al, 2005;de Heredia et al, 2007;Caldwell et al, 2014;Chen et al, 2015), and other studies found no effect for DHEA on body weight (Lea-Currie et al, 1997 a, b;Aragno et al, 2004;Sander et al, 2006;Miyazaki et al, 2016).…”

“…The decrease in body weight gain was dose-dependent. This observation in in line with previous studies, which reported that DHEA administration reduce body weight gain (Shepherd and Cleary, 1984;Cleary and Zisk, 1986;Cleary, 1991;Svec et al, 1995;Abadie et al, 2000;Zhao et al, 2007;Ma et al, 2008;Hakkak et al, 2010Hakkak et al, & 2017. The decrease in body weight gain may be related to the decrease in food intake (Weindruch et al, 1984), or related to the decrease the abdominal or body fats (Cleary and Zisk, 1986;Villareal and Holloszy, 2004;Ma et al, 2008).…”

Effects of maggot antimicrobial peptides on growth performance, immune function, and cecal flora of yellow-feathered broilers

“…Previous studies have shown that adding antimicrobial peptides to feed can improve animal serum indicators ( 32 , 33 ). It found that adding 100 mg/kg antimicrobial peptide to the Luhua chicken diet could significantly increase the serum total protein content at 42 and 70 days of age and improve the albumin content, consistent with our study ( 34 ).…”

“…It found that adding 100 mg/kg antimicrobial peptide to the Luhua chicken diet could significantly increase the serum total protein content at 42 and 70 days of age and improve the albumin content, consistent with our study ( 34 ). Furthermore, adding 100 mg/kg antimicrobial peptide could increase the levels of IgG and IgM in broilers at 35 days of age ( 32 ). Moreover, it also found that SGAMP increased IgA levels in broiler serum ( 35 ).…”

Dietary Supplementation with Aqueous Extract of Talinum triangulare at Different Phases of Broiler Production and Effect on Growth, Serum Biochemistry and Carcass Quality

“…In the poultry industry, the production of broiler chickens with excessive body fat is currently seen as a significant economic problem (Ma et al, 2008). The deposition of abdominal fat in broilers results in increased feed cost and poor final meat quality (Assaf et al, 2004).…”