Effects of Dehydroepiandrosterone and Atamestane Supplementation on Frailty in Elderly Men

Muller, Majon; Beld, Annewieke W. van den; Schouw, Yvonne T. van der; Grobbee, Diederick E.; Lamberts, Steven W. J.

doi:10.1210/jc.2005-2433

Cited by 54 publications

(65 citation statements)

References 16 publications

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“…It is well established that androgens increase muscle mass in men (26)(27)(28), while the possible role of estrogens and ERs for muscle mass in men remains unclear. Clinical trials investigating the effects of aromatase inhibition in older men showed no effect of the intervention on body composition or muscle strength (29,30) and, thus, did not support an important role of serum E 2 levels for lean mass in men. Nevertheless, animal studies have indicated that not only AR activation but also ER activation modulates lean mass (31)(32)(33)(34).…”

Section: Discussionmentioning

confidence: 91%

Serum estradiol is associated with lean mass in elderly Swedish men

Vandenput

Mellström

Karlsson

et al. 2010

European Journal of Endocrinology

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Objective: Association studies in men have shown that androgens are inversely related to fat measures, while the relation between sex steroids and lean mass remains unclear. We, therefore, investigated the associations between serum sex steroid levels and body composition in elderly men with a main focus on lean mass measures. Design and methods: A cross-sectional survey of a population-based cohort of 3014 elderly men, aged 69-80 years (Osteoporotic Fractures in Men study, Sweden). Serum levels of testosterone and estradiol (E 2 ) were measured by mass spectrometry, sex hormone-binding globulin (SHBG) levels were measured by IRMA, and measures of body composition were obtained by dual-energy X-ray absorptiometry. Results: Total as well as free serum testosterone associated independently inversely (P!0.001), while total as well as free serum E 2 associated independently directly (P!0.001) with total body fat mass and trunk fat mass. Serum SHBG associated independently inversely with central fat distribution. Serum E 2 and free E 2 but not serum testosterone or free testosterone levels associated positively with lean mass (P!0.01). Elderly men within the lowest quartile of free E 2 had 0.5 kg less lean mass in the legs than subjects within the highest quartile, while the subjects in the different quartiles of free testosterone did not differ in lean mass. Conclusions: Serum E 2 , but not serum testosterone, is directly associated with lean mass in this large study of elderly Swedish men. In addition, serum SHBG is associated with central fat distribution and we confirmed that serum testosterone is inversely associated with fat mass.

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Section: Discussionmentioning

confidence: 91%

Serum estradiol is associated with lean mass in elderly Swedish men

Vandenput

Mellström

Karlsson

et al. 2010

European Journal of Endocrinology

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“…Aromatase inhibitors have been used in boys with idiopathic short stature to promote linear growth (24,25), in eugonadal young adults to study metabolic effects (26,27), and in eugonadal and hypogonadal elderly to examine the effect on frailty (26,28,29). The only clinical effect shown thus far is an increase in body height of about 6 cm in boys with idiopathic short stature, i.e.…”

Section: Previous Experience With Aromatase Inhibitionmentioning

confidence: 99%

Somatic and psychological effects of low-dose aromatase inhibition in men with obesity-related hypogonadotropic hypotestosteronemia

Loves

Jong

Sorge

et al. 2013

European Journal of Endocrinology

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“…Eight of the 11 studies used specific criteria to select "frail" participants, although these criteria were variously defined. 10e13, 15,16,18,19 In the other three studies, two enrolled people only by age (>70 years) 17,20 and the remaining one enrolled frail or fractured older adults. 14 All studies agreed that decline in physiological reserves is an important component of frailty, although they operationalized the concept differently.…”

Section: Study Population and Frailty Indicatorsmentioning

confidence: 99%

“…11,18,19 Isometric grip strength and leg extensor power were used in one study. 16 Another used the short physical performance battery to evaluate effectiveness of frailty intervention. 10 One study specified the rapid-gait test, stand-up test, and Barthal index as its frailty indicators.…”

Section: Study Population and Frailty Indicatorsmentioning

confidence: 99%

Interventions targeting geriatric frailty: A systemic review

Lee

Chan

2012

Journal of Clinical Gerontology and Geriatrics

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a b s t r a c tGeriatric frailty has drawn growing interest in recent years for its associations with multiple adverse outcomes. Previous studies showed that interventions may improve some aspects of frailty such as physical function. However, interventions targeting the entire frailty construct have not been systemically reviewed. We conducted a comprehensive search for randomized controlled trials targeting geriatric frailty. Only trials that measured outcomes based on their predefined frailty indicators were included. Of 98 articles, 11 met the inclusion criteria. Eight studies were classified as high quality. Of the six exercise-based interventions, five showed significant improvements on at least two of their frailty indicators. Hormone replacement therapy was not effective. Two of the three multifactorial interventions have not published their results, and the third did not show significant improvements. More studies with standardized definitions and measurements of frailty are needed to determine the effectiveness of interventions on geriatric frailty.

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Effects of Dehydroepiandrosterone and Atamestane Supplementation on Frailty in Elderly Men

Abstract: The results of this double-blind, randomized trial do not support the hypothesis that hormone replacement with DHEA and/or atamestane might improve the course of frailty.

Cited by 54 publications

References 16 publications

Serum estradiol is associated with lean mass in elderly Swedish men

Serum estradiol is associated with lean mass in elderly Swedish men

Somatic and psychological effects of low-dose aromatase inhibition in men with obesity-related hypogonadotropic hypotestosteronemia

Interventions targeting geriatric frailty: A systemic review

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