Effects of Deficiency and Excess of Thyroid Hormone on the Distribution of Fatty Acids in Lipids of the Rat

Ellefson, Ralph D.; Mason, Harold L.

doi:10.1210/endo-75-2-179

Cited by 24 publications

(12 citation statements)

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“…Other authors have reported variations with a small amplitude (9). We would tentatively conclude that hypothyroidism has important quantitative effects upon the TG metabolism o f several tissues, but does not seem to alter qualita tively these TG.…”

Section: E Ffect O F Cretinism Upon Brown Adipose Tissuesupporting

confidence: 52%

“…Normal rat fetuses and neonates, as well as hypo thyroid neonates were studied, since we have found in a previous work that cretinism induces marked alterations of the T G metabolism in the brown and white adipose tissues of tire rat (14). Moreover, it has been shown that the modifications of the fatty acid pattern of tissue lipids are correlated with altera tions o f the thyroid status o f adult rats (9).…”

Section: Introductionmentioning

confidence: 99%

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A Study of Phospholipids and Triglycerides in Several Tissues of the Rat during Fetal and Neonatal Development

Ricquier¹,

Hemon²

1976

Neonatology

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Gas-liquid chromatography analysis of triglyceride (TG) and phospholipid (PL) fatty acids was performed in several tissues of the rat during fetal and neonatal development and the effect of cretinism investigated. Liver and brown fat had a low TG content in the fetus, the TG of brown fat being characterized by a high proportion of saturated fatty acids; only saturated fatty acids were synthetized from glucose by brown fat fragments. The onset of suckling was followed by an immediate accumulation of TG in liver and brown fat, and the fatty acid pattern of these TG was modified, but in opposite directions; the proportion of arachidonic acid increased in the PL of all tissues. Propylthiouracil feeding of the mother from the day of birth induced an abnormal accumulation of TG in the brown adipose tissue of the rat by the time they had the syndrome of cretinism. The fatty acid pattern of these TG was similar to that of controls.

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Section: E Ffect O F Cretinism Upon Brown Adipose Tissuesupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

A Study of Phospholipids and Triglycerides in Several Tissues of the Rat during Fetal and Neonatal Development

Ricquier¹,

Hemon²

1976

Neonatology

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“…A number of studies have indicated that thyroid hormones markedly affect lipid metabolism in man and in several species of animals. Thyroxine administration to normal rats increases the hepatic concentrations of all fatty acids, especially those in phospholipid and free fatty acid fractions (40). Therefore, it is possible that the lower phospholipid concentrations observed by us in the SMSG and lacrimal glands of rats fed vitamin E-supplemented diets may be due to lower thyroid hormone levels.…”

Section: Omentioning

confidence: 74%

Effect of Vitamin E on Lipid Composition of Submandibular and Lacrimal Glands in Rats

Alam¹,

Alam²

1979

Experimental Biology and Medicine

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“…In the treated group (n = 12), eicosapentaenoic acid (3.5 g/day) and docosahexaenoic acid (1.5 g/day) (Promega, Parke-Davis, Morris Plains, N.J.) were added to the regular diet for 4 weeks. At the beginning and the end of the 4-week period, the plasma concentration of lipids (enzymatic method 19 ) and the fatty acid profiles (gas chromatographic method 20 ) were determined. After 4 weeks, the animals were euthanatized with ketamine (300 mg i.m.…”

Section: Methodsmentioning

confidence: 99%

Dietary omega-3 fatty acids and endothelium-dependent responses in porcine cerebral arteries.

Kim

Shimokawa

Vanhoutte

1992

Stroke

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Purpose: We sought to determine the effect of dietary -3 polyunsaturated fatty acids enhances endotheliumdependent relaxations in the basilar artery by two mechanisms: 1) replacement of endogenous arachidonic acid and suppression of the concomitant release of vasoconstrictor prostaglandins from the endothelium, and 2) enhancement of the release of endothelium-derived relaxing factor. (Stroke 1992;23:407-413) KEY WORDS • basilar artery • endothelium-derived relaxing factor • fatty acids, unsaturated • pigs T he dietary intake of large amounts of marine oils rich in w-3 polyunsaturated fatty acids probably accounts for the low incidence of coronary artery disease among Greenland Eskimos.1 High contents of (o-3 polyunsaturated fatty acids, especially eicosapentaenoic acid, are found in the plasma and platelets of Eskimos.2 ? Eicosapentaenoic acid is transformed into trienoic prostanoids, such as thromboxane A 3 and prostaglandin I 3 .4 -6 Thromboxane A 3 does not possess proaggregatory activity, unlike the dienoic prostanoid thromboxane A 2 , 7 and prostaglandin I 3 has effects comparable to those of prostacyclin.5 Hence, supplementation with (o-3 fatty acids inhibits platelet aggregation and prolongs bleeding time, presumably due to the decreased production of thromboxane A 2 . 8 Previous studies demonstrate that dietary supplementation with cod-liver oil or purified co-3 fatty acids augments endothelium-dependent relaxations in isoFrom the Department of Physiology and Biophysics (P.K., H.S.), Mayo Clinic, Rochester, Minn., and the Center for Experimental Therapeutics (P.M.

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Effects of Deficiency and Excess of Thyroid Hormone on the Distribution of Fatty Acids in Lipids of the Rat

Cited by 24 publications

References 0 publications

A Study of Phospholipids and Triglycerides in Several Tissues of the Rat during Fetal and Neonatal Development

A Study of Phospholipids and Triglycerides in Several Tissues of the Rat during Fetal and Neonatal Development

Effect of Vitamin E on Lipid Composition of Submandibular and Lacrimal Glands in Rats

Dietary omega-3 fatty acids and endothelium-dependent responses in porcine cerebral arteries.

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