Effects of deep brain stimulation of the subthalamic nucleus on inhibitory and executive control over prepotent responses in Parkinson's disease

Jahanshahi, Marjan

doi:10.3389/fnsys.2013.00118

Cited by 79 publications

(76 citation statements)

References 148 publications

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“…For what concerns food reward, no differences in pleasantness ratings of appetizing food have been observed between PD and matched controls (Macht, Brandstetter, & Ellgring, 2007;Sienkiewicz-Jarosz et al, 2005, 2013. In contrast, motivational responses to food can be altered in PD patients.…”

Section: Motivation and Rewardmentioning

confidence: 66%

“…Moreover, the association between depression and a reduced BMI has been observed in men but not in women (Pilhatsch et al, 2013). Even if both changes in cognitive functions and emotional processes may be side effects of DBS (Castrioto, Lhommée, Moro, & Krack, 2014;Jahanshahi, 2013;Troster, 2009), no association so far has been observed between MMSE (Serranová et al, 2011) or BDI (Locke et al, 2011;Macia et al, 2004;Serranová et al, 2011) and weight gain after surgery. In conclusion, studies on the relation between cognitive deficits, depression, and weight are sparse and often exclude patients with severe cognitive or emotional disturbances.…”

Section: Cognition and Moodmentioning

confidence: 87%

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Body weight and food intake in Parkinson's disease. A review of the association to non-motor symptoms

2015

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Section: Motivation and Rewardmentioning

confidence: 66%

Section: Cognition and Moodmentioning

confidence: 87%

Body weight and food intake in Parkinson's disease. A review of the association to non-motor symptoms

2015

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“…An increasing body of evidence based on STN DBS on vs. off methodology also suggests that STN DBS in PD patients is associated with a deficit in inhibitory control over proponent responses (Jahanshahi, 2013;Jahanshahi, Obeso, Rothwell, & Obeso, 2015). The STN receives direct cortical information through the "hyperdirect pathway" (Monakow, Akert, & Kunzle, 1978;Nambu, Tokuno, & Takada, 2002), which is then relayed to the basal ganglia output structures.…”

Section: Discussionmentioning

confidence: 99%

In Parkinson’s disease STN stimulation enhances responsiveness of movement initiation speed to high reward value

2016

Self Cite

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“…For instance, Chiken and Nambu (2014) reviewed studies arguing that deep brain stimulation work by disrupting abnormal signal transmission in PD, dystonia, and tremor, while Smith et al (2014) reviewed data on the role of thalamo-striatal pathway in motor symptoms in PD, and suggest that deep brain stimulation to this pathway can aid in the treatment of PD symptoms. Unlike these reviews, Jahanshahi (2013) reviewed recent studies on the effects of subthalamic deep brain stimulation on motor and cognitive processes in PD, focusing on inhibitory and cognitive control. This review shows that beside motor processes, deep brain stimulation has a complex effect on cognitive control as well as other cognitive processes.…”

Section: Reviewsmentioning

confidence: 99%

Basal ganglia: physiological, behavioral, and computational studies

2015

Frontiers Research Topics

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Keywords: basal ganglia, dopamine, Parkinson's disease (PD), computational modeling, animal studies, human imaging studies, deep brain stimulationThe basal ganglia has received much attention over the last two decades, as it has been implicated in many neurological and psychiatric disorders, including Parkinson's disease (PD), Attention Deficit Hyperactivity Disorder (ADHD), Tourette's syndrome, and dystonia. Most of current basal ganglia research-in both animals and humans-attempts to understand the neural and biochemical substrates of basic motor and learning processes, and how these are affected in human patients as well as animal models of brain disorders, particularly PD.The current volume contains research articles and reviews describing basic, pre-clinical and clinical neuroscience research of the basal ganglia written by researchers of the basal ganglia and attendees of the 11th Triennial Meeting of the International Basal Ganglia Society (IBAGS) that was held on March 3-7th, 2013 at the Princess Hotel, Eilat, Israel. Specifically, articles in this volume include research reports on the biochemistry, computational theory, anatomy, and physiology of single neurons and functional circuitry of the basal ganglia networks.Below, we provide a summary of articles published in the volume. We divided the articles into 4 sections: animal studies, human studies, computational modeling, and reviews. ANIMAL STUDIESUsing physiological recordings, Adler et al. (2013) studied the relationship of both medium spiny cells and interneurons of the striatum while monkeys were performing a Pavlovian conditioning task, showing that both classes of neurons play a key role in conditioning. Along these lines, Yael et al. (2013) studied the effects of D2 antagonists (haloperidol) on striatal activity, finding evidence that it alters firing patterns of medium spiny cells and interneurons. Interestingly, Bronfeld et al. (2013) found that microinjection of the GABA A antagonist bicuculline in the dorsal striatum leads to Tourette's tics in rats, potentially highlighting a role of interneurons in such motor symptoms. However, future studies should explain the exact function of interneurons in the generation of tics. In another study, Plata et al. (2013) found that the administration of nicotine activates inhibitory interneurons in the striatum, which can treat motor symptoms of PD (as similar to dopaminergic medications). The implications of these findings remain to be shown in clinical studies. Using whole-cell patch-clamp recordings, Arias-Garcia et al. (2013) found, for the first time, that Ca 2+ -activated K + channels explain the different durations between corticostriatal responses in the basal ganglia direct and indirect pathways. Future research should explain the relationship between these findings and motor symptoms in PD.While the above studies focus on the striatum, other studies in the volume address the function of other downstream basal ganglia structures. For example, Lavian et al. (2013) studied the effects of high and...

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Effects of deep brain stimulation of the subthalamic nucleus on inhibitory and executive control over prepotent responses in Parkinson's disease

Cited by 79 publications

References 148 publications

Body weight and food intake in Parkinson's disease. A review of the association to non-motor symptoms

Body weight and food intake in Parkinson's disease. A review of the association to non-motor symptoms

In Parkinson’s disease STN stimulation enhances responsiveness of movement initiation speed to high reward value

Basal ganglia: physiological, behavioral, and computational studies

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