SUMMARYA study has been made of the intestinal handling of water and electrolytes following the relief of smallbowel obstruction. A new technique has been described for perfusing the ileum of conscious animals. It has been shown that the ileum secretes water and electrolytes for at least 48 hours following the relief of obstruction, and that decompression increases this fluid loss during the first 6 hours after surgery. It is suggested that the fluid and electrolyte requirements during this period will be increased when decompression is performed.SMALL intestinal obstruction is a common surgical problem ( Table I) and Hoguet (1912) showed, in dogs, how important the loss of fluid and electrolytes from the obstructed gastro-intestinal tract was. Later it was suggested that this fluid loss was due to increased biliary, pancreatic, and gastro-intestinal secretions, but the exact role of the small bowel was not defined until Shields (1965) showed that obstructed bowel begins to secrete, rather than absorb, water and electrolytes within 12 hours of the onset of intestinal obstruction and that the rate of secretion increases with time. Nothing, however, is known about the handling of water and electrolytes by the small bowel after * Present address: Senior Registrar, St. Thomas's Hospital, London. second operation. At this second laparotomy the tubes for intestinal perfusion were positioned in the loop of bowel immediately above the site of the obstruction.The subsequent handling of water and electrolytes was studied by perfusing the bowel 6, 24, and 48 hours after the second operation. Since perfusion has not previously been used to study the handling of water and electrolytes in the conscious animal, the technique is described in detail (Fig.