Effects of Decaserpine on the Content of Catecholamine in the Brain, Atrium and Adrenal Gland of Rabbit

Higuchi, Hideo; Matsuo, Takaaki; Nakatani, George; Shimamoto, Kiro

doi:10.1254/jjp.13.36

Cited by 8 publications

(4 citation statements)

References 6 publications

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“…Three hours after 10 mg/kg of 10-MD the noradrenaline content was reduced by 54% in the brain cortex, by 68% in the brain stem and by 77% in the atria, while the serotonin content was reduced by 40% in the brain cortex and by 57% in the brain stern. The similar reduction on the tissue cate cholamine byo 10-MD has been shown by Higuchi et al (7). The lesser depletion of noradrenaline or serotonin by 10-MD than by reserpine (10,16,17) (18)(19)(20).…”

Section: Discussionsupporting

confidence: 70%

Effects of 10-Methoxydeserpidine and Reserpine on the Skin and Rectal Temperature in Rabbits

Toda

Shimamoto

Fujiwara

1964

Japanese Journal of Pharmacology

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Although the peripheral effects of reserpine are generally accepted, there is evidence to support the central action on the adrenal medulla (1)(2)(3)(4)(5). No depletion of tissue nor adrenaline by 10-methoxydeserpidine (10-MD) has been reported in mice by Leroy and Schaepdryver (6). However, Higuchi et al. (7) have shown that the intravenous injec tion of 10-MD in rabbits depletes considerably the content of noradrenaline in the brain cortex, brain stem and heart, and of adrenaline in the adrenal medulla without mani festing sedation or diarrhea.10-MD has recently been used clinically for the essential hypertension. Episode of the side effect that hyperemia and warm sensation of the face and neck manifest in some patients several hours after the oral administration has been reported (8). No such side effect has hitherto been reported in the case of reserpine. Therefore, the current report deals firstly with elucidation of action mechanism of the hyperemia and warm sensation in the face and neck caused by 10-MD, and secondarily with the phar macological difference between reserpine and 10-MD. The results in the present ex periments have shown that though reserpine produces a marked elevation of the ear temperature followed by a steady fall of the rectal temperature , 10-MD elicits a similar elevation of the ear temperature attended with no change in the rectal temperature in rabbits. METHODSThe effects of the intravenous injection of reserpine and 10-MD on the ear, thigh and rectal temperature, the spontaneous electroencephalogram (EEG), the electrocardio gram (ECG), the respiration and the content of adrenaline, noradrenaline and serotonin of the various tissues were investigated in albino rabbits, weighing 2.0 to 2.5 kg of either sex, at the room temperature of 24±0.3°C. The animals anesthetized at the stage III (plane 2 or 3) with ether were fixed on the stereotaxic instrument in an abdominal position. The surgical procedures were performed during the anesthesia. The full awaking on the EEG pattern was usually obtained about one hour after the termina tion of ether inhalation. The experiments were commenced after the stabilization of

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Section: Discussionsupporting

confidence: 70%

Effects of 10-Methoxydeserpidine and Reserpine on the Skin and Rectal Temperature in Rabbits

Toda

Shimamoto

Fujiwara

1964

Japanese Journal of Pharmacology

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“…Effects of Decaserpinl on EEG Recorded from the Motor Cortex Higuchi et al (4) have showed that the intravenous injection of 5 mg/kg of deca serpine in rabbit depletes brain noradrenaline and the peak effect is attained two to three hours after the injection. The preliminary experiments confirmed also that the intravenous injection of 5 mg/kg of decaserpine affected the spontaneous EEG of the motor cortex in rabbits.…”

Section: Resultsmentioning

confidence: 99%

Effects of Decaserpine on the Electroencephalogram of Rabbit

Nakanishi

Yamamoto

1963

Japanese Journal of Pharmacology

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The dissociation between EEG and behavior produced by reserpine in rabbit was firstly demonstrated by Rinaldi and Himwich (1). Kikuchi (2) confirmed the result that the increase of the component of the resting waves in EEG at early period of reserpine action was followed by the arousal waves. He observed the appearance of the arousal waves of EEG in all of the animals which showed a clear-cut marked sedation during 4 to 10 hours after the administration of reserpine. He further showed that the pretreatment of rabbit with methamphetamine reversed the effect of reserpine on EEG. In the early period of reserpine action the EEG of rabbit showed an arousal pattern, and later it exhibited a pattern of the resting waves, which was observed within 10 hours or more after the administration.The pharmacological effects of decaserpine (10-methoxy deserpidine) have been reported by Mir and Lewis (3). Decaserpine did not produce sedation in a variety of animals and even large doses of decaserpine did not prolong barbiturate sleep in mice. The drug did not also produce ptosis or diarrhoea.However, when the initial blood pressure was considerably high in cat, the administration of decaserpine produced a gradual fall, and the same procedure depressed the pressor response elicited by electrical afferent stimulation of the cervical vagal nerve. The depletion of catecholamine in the brain, atrium and adrenal gland by the intravenous injection of decaserpine in rabbit has been shown by Higuchi et al. (4). The decrease of the level of brain noradrenaline was maximal about three hours after the injection. The duration of the depletion of brain noradrenaline produced by the intravenous injection of decaserpine was shorter than that produced by the sane pro cedure of reserpine. The decrease of the level of brain noradrenaline caused by decaserpine almost recovered twelve hours after the injection.The depletion of noradrenaline in brain shown by Higuchi et al. (4) urged strongly the present study of the effect of decaserpine on the spontaneous EEG in rabbit. METHODSAlbino rabbits, weighing 2.0 to 3.5 kg were used. After the animal had been anesthetized with ether and a tracheal cannula had been inserted, the skull of the

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“…10-Methoxydeserpidine, in doses of 2 to 4 mg/kg, was shown to result in continual hypotensive action in anesthetized cats (9, 10). Higuchi et al (13) reported that 1 mg/kg of 10-methoxydeserpidine reduced the content of atrial norepinephrine markedly, while norepinephrine in the brain decreased slightly.…”

Section: Tetrabenazine Combined With Grid Shockmentioning

confidence: 99%

Studies on the Experimental Gastrointestinal Ulcers Produced by Reserpine and Stress

Doteuchi

1968

Japanese Journal of Pharmacology

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Effects of Decaserpine on the Content of Catecholamine in the Brain, Atrium and Adrenal Gland of Rabbit

Cited by 8 publications

References 6 publications

Effects of 10-Methoxydeserpidine and Reserpine on the Skin and Rectal Temperature in Rabbits

Effects of 10-Methoxydeserpidine and Reserpine on the Skin and Rectal Temperature in Rabbits

Effects of Decaserpine on the Electroencephalogram of Rabbit

Studies on the Experimental Gastrointestinal Ulcers Produced by Reserpine and Stress

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