EFFECTS OF DECAMETHONIUM BROMIDE (C10) AND d-TUBOCURARINE ON ELECTROCONVULSIONS

Margolis, Lester H.; Simon, Attila; Bowman, Karl M.

doi:10.1001/archneurpsyc.1951.02320020046004

Cited by 4 publications

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“…Margolis (18) and his co-workers also preferred decamethomium bromide to tubocurarine, which in many cases did not produce optimal relaxation, in others caused respiratory distress, and in still others was followed by pronounced histamine-like reactions. Their review covered a relatively small number of treatments.…”

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Relaxants in Electro-Therapy; Technique and a Comparative Evaluation

Nl¹

1956

Canadian Psychiatric Association Journal

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1) An attempt is made to clarify and standardize the technique and modification of electro-convulsive therapy. 2) The literature is briefly reviewed. 3) A technique suitable for outpatient, hospital or private practice use is suggested and discussed. Kindly and proper handling of the patient, the time element, nursing requirements, and the training of medical staff were among the factors considered in the description of this technique. 4) A total of 1863 treatments were given to 246 female patients by the author over an arbitrary period and under exactly similar conditions. The limitation of the trial to females is coincidental. 5) For the first time 8 different muscle relaxants are compared and assessed in the same paper. Six of these relaxants were given to 25 of the patients in a partially unsuccessful attempt to give each of these patients a trial with each relaxant on at least one occasion. 6) It is concluded that physical disease or age do not contra-indicate the use of E.C.T. provided this is modified. 7) It is further concluded that suxethonium bromide is at least as satisfactory, and in most cases more satisfactory, than the other relaxant drugs used for the modification of electro-shock therapy. The drugs were assessed for this purpose in terms of occurrence of fracture, degree of apnoea produced, contra-indications, antidotes, effect upon blood pressure and pulse, production of histamine-like effects, excessive secretions, cyanosis, subjective ill effects, extent of muscle fasciculations, degree of relaxation, modification of the convulsion, time required, and finally—ease of handling.

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confidence: 99%