Effects of dark-rearing on the vascularization of the developmental rat visual cortex

Argandoña, Enrike; Lafuente, José Vicente

doi:10.1016/0006-8993(96)00485-4

Cited by 51 publications

(47 citation statements)

References 32 publications

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“…We have previously reported that the main quantitative experience-induced vascular changes occur at the beginning of the critical period, where some authors have dated the peak of the neuronal critical period (Argandoñ a and Lafuente, 1996Lafuente, , 2000Berardi et al, 2000;Argandoñ a and Lafuente, 2002;Argandoñ a et al, 2005). Our previous results suggest that the increase of experience induces an increase in vascular density mediated by a peak in the secretion of VEGF.…”

Section: Vascular Densitymentioning

confidence: 63%

“…This peak occurs at the 4th postnatal week, shortly after the end of the minipump placement (Bengoetxea et al, 2008). The implantation-produced lesion induces a significantly lower increase of vascular density, which is one of the changes related to the postnatal maturation of the visual cortex (Argandoñ a and Lafuente, 1996Lafuente, , 2000Lafuente, , 2002Argandoñ a et al, 2005;Bengoetxea et al, 2008). Several authors have reported that brain injuries in developing animals generate a delay in plasticity without gross morphological damage (Prins et al, 1996;Fineman et al, 2000;Adelson et al, 2001;Argandoñ a et al, 2006;Gurkoff et al, 2006).…”

Section: Vascular Densitymentioning

confidence: 99%

“…These changes lead to an increase in metabolic demand (Black et al, 1990;Harrison et al, 2002) that is satisfied by the adaptive remodeling of the vascular network (Sirevaag et al, 1988;Argandoñ a and Lafuente, 1996;Tieman et al, 2004;Bengoetxea et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Previously, we have studied the effects of visual experience on the cortex vasculature, reporting that during the critical period the vascular density and the maturation of the vascular pattern correspond to the level of activity (Argandoñ a and Lafuente, 1996Lafuente, , 2000Lafuente, , 2002Argandoñ a et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Effect of intracortical vascular endothelial growth factor infusion and blockade during the critical period in the rat visual cortex

et al. 2012

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Section: Vascular Densitymentioning

confidence: 63%

Section: Vascular Densitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of intracortical vascular endothelial growth factor infusion and blockade during the critical period in the rat visual cortex

et al. 2012

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“…Capillary density appears to develop in accordance with local functional demands [41]. Increase in metabolic demand produces significant growth of new capillaries, while decreased activity reduces vascular growth [42,43,44,45]. Decreased VEGF mRNA expression has been recently reported in the dorsolateral prefrontal cortex of schizophrenia subjects [24].…”

Section: Discussionmentioning

confidence: 97%

Reduced Capillary Density in the Prefrontal Cortex in Schizophrenia

Uranova¹,

Zimina²,

Vikhreva³

et al. 2013

AJMSM

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Neuroimaging studies have shown that the core symptoms of schizophrenia are associated with local changes of cerebral blood flow, particularly in the frontal cortex. Previously we reported ultrastructural damage of capillaries in the upper layers of the prefrontal cortex, Brodmann's area (BA) 10 and in the visual cortex, BA 17 in schizophrenia. An electron microscopic morphometric study was performed to estimate capillary area density (N cap/mm 2 ) in two upper layers of the prefrontal and visual cortices in 26 cases of schizophrenia and 26 normal controls. Capillary area density was lower in the prefrontal cortex in the schizophrenia group (-24%, p < 0.001) and in the subgroup of schizophrenia with predominantly negative symptoms (n=12, -35%, p < 0.001) as compared to controls. Group and subgroup differences were absent in the visual cortex. Dysfunction of neocortical microvasculature in schizophrenia is related to region-specific capillary deficiency in the prefrontal cortex. These changes might contribute to the lowered blood flow, reduced glucose metabolic rates, resting hypofrontality and hypoactivation reported in the prefrontal cortex of patients with schizophrenia.

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Light‐dependent retinal innervation of the rat superior colliculus

Prichard

Armacanqui

Benca

et al. 2007

The Anatomical Record

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Mammalian retinal projections are divided into two anatomically and functionally distinct systems: the primary visual system, which mediates conscious visual processing, and the subcortical visual system, which mediates nonconscious responses to light. Light deprivation during a critical period in development alters the anatomy, physiology, and function of the primary visual system in many mammalian species. However, little is known about the influence of dark-rearing on the development of the subcortical visual system. To evaluate whether the early lighting environment alters the anatomy of the subcortical visual system, we examined the retinas and retinofugal projections of rats reared in a 12:12 light/dark cycle or in constant dark from birth to 4 months of age. We found that dark-rearing was associated with a reduction in the distribution of retinal fibers in the stratum opticum of the contralateral superior colliculus. In contrast to the plasticity of the retinocollicular projection, retinal input to sleep, circadian, and pupillary control centers in the hypothalamus, pretectum, and lateral geniculate complex was unaffected by dark-rearing. A decrease in retinal innervation of the stratum opticum and intermediate layers of the superior colliculus may account for some of the deficits in multisensory integration that have been observed in dark-reared animals of several species. Anat Rec, 290:341-348, 2007. 2007 Wiley-Liss, Inc.

show abstract

Effects of dark-rearing on the vascularization of the developmental rat visual cortex

Cited by 51 publications

References 32 publications

Effect of intracortical vascular endothelial growth factor infusion and blockade during the critical period in the rat visual cortex

Effect of intracortical vascular endothelial growth factor infusion and blockade during the critical period in the rat visual cortex

Reduced Capillary Density in the Prefrontal Cortex in Schizophrenia

Light‐dependent retinal innervation of the rat superior colliculus

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