Effects of Daniellia oliveri stem bark and leaf extracts on rat skeletal muscle

Abstract

The stem bark and leaves of Daniellia oliveri were screened phytochemically and the effects of their respective methanol extracts on the skeletal muscle of rats were investigated using the isolated phrenic nerve hemidiaphragm muscle preparation. Both were found to contain tannins, cardiac and saponin glycosides. In addition, the bark, but not leaves, contained cyanogenetic glycosides. The methanol extracts were found to possess neuromuscular blocking properties. The leaf extract appeared to act primarily by inhibiting the influx of extracellular Ca(2+) principally by inhibiting K(+) channels. The inhibitory action of the bark extract appeared to be mediated by interference with transmitter release and an action on multiple sites.

Antimalarial Assay, Isolation, and Characterization of Compounds Responsible for Antimalarial Activity in Daniellia oliveri (Rolfe) Hutch. and Dalziel (Caesalpiniaceae)

“…Several research investigating various pharmacological activities have been done on the plant. The stem bark methanol extract has been shown to have neuromuscular blocking activity [8]. The oleoresin has antioxidant anticytotoxic activities [9,10].…”

Daniellia oliveri Leaf Extracts as an Alternative to Antibiotic Feed Additives in Broiler Chicken Diets: Meat Quality and Fatty Acid Composition

“…Scientific studies have revealed that the roots, stems, and leaves demonstrated a considerable antimicrobial (Jimoh and Oladiji, 2005), anti-inflammatory (Oyegade et al, 1999;Muanda et al, 2011), cytotoxic (Topcu et al, 1993;, antihyperglycaemic (Iwueke and Nwodo, 2008), antioxidant (Ahmadu et al, 2004), anti-diarrheal (Ahmadu et al, 2007), immunostimulatory (Lamy et al, 2010), hepatoprotective (Olatunji, 2000;Alagbe et al, 2017) and miracicidal activities (Arnao et al, 1998;. The plant parts contain various phytochemicals (tannins, flavonoids, saponins, phenols, alakloids, terpenoids, glycosides), minerals, amino acids, and vitamins and they can be traditionally used for the treatment of malaria, typhoid, skin diseases, gastro intestinal infections, urinary infections and toothache Onwukaeme et al, 1999;Musa et al, 2000).…”

Potential new drug targets and therapeutic approaches for parasitic nematode infections

“…Cardiac glycosides present in the methanol extract of the bark showed non-competitive antagonism on muscarinic receptors on isolated rat bladder smooth muscle (Onwukaeme et al, 1999a). Methanol extracts of the leaves and stem bark were showed to possess neuromuscular blocking properties on rat skeletal muscle (Onwukaeme et al, 1999b). The smoke of the bark of D.…”