Effects of Dangshen Yuanzhi Powder on learning ability and gut microflora in rats with memory disorder

Ren, Haiqin; Gao, Shouqin; Wang, Shihui; Wang, Jiamin; Cheng, Yangang; Wang, Yan; Wang, Yingli

doi:10.1016/j.jep.2022.115410

Cited by 10 publications

(10 citation statements)

References 54 publications

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“…This is done by influencing the composition and metabolic activity of the intestinal flora and thereby regulating intestinal microecological balance. Studies have shown that Dangshen Yuanzhi Powder improves the learning and memory ability of memory-disordered (MD) animals by reducing the relative ratio of Firmicutes/Bacteroidetes and restoring intestinal flora disorder ( Ren et al, 2022 ). Meanwhile, the regulation of blood biochemical indices by Dangshen Yuanzhi Powder in MD animals was significantly correlated with the regulation of intestinal flora ( Ren et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…TNF-α belongs to the TNF ligand superfamily, which is mainly secreted by macrophages and lymphocytes ( Yuk et al, 2024 ), and promotes the production and secretion of IL-1β and IL-6. TNF-α regulates imbalances in immune regulation ( Deng et al, 2020 ), inflammation ( Xu Q. et al, 2023 ), cancer ( Zhu et al, 2019 ), memory disorders ( Ren et al, 2022 ) and other diseases. In Xu et al’s study, Dangshen Huangjiu (DHJG) achieved the efficacy of preventing gastric mucosal injury by elevating SOD and decreasing MDA, increasing antioxidant capacity, and inhibiting the AKT/NF-κB signaling pathway to decrease the expression of inflammatory factors TNF-α, IL-1β, and IL-6 in the chronic non-atrophic gastritis model of Wistar rats ( Xu Q. et al, 2023 ).…”

Section: Subsections Relevant For the Subjectmentioning

confidence: 99%

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A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

Guo,

Lou,

Hou

et al. 2024

Front. Pharmacol.

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As a traditional Chinese medicinal herb with a long history, Codonopsis pilosula (CP) has attracted much attention from the medical community in recent years. This review summarizes the research progress of CP in the medical field in the past 5 years. By searching and analyzing the literature, and combining with Cytoscape software, we comprehensively examined the role and mechanism of action of CP in individual application, combination drug application, and the role and mechanism of action of codonopsis pilosula’s active ingredients in a variety of diseases. It also analyzes the medicinal use of CP and its application value in medicine. This review found that CP mainly manifests important roles in several diseases, such as cardiovascular system, nervous system, digestive system, immune system, etc., and regulates the development of many diseases mainly through the mechanisms of inflammation regulation, oxidative stress, immunomodulation and apoptosis. Its rich pharmacological activities and diverse medicinal effects endow CP with broad prospects and application values. This review provides valuable reference and guidance for the further development of CP in traditional Chinese medicine.

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Section: Discussionmentioning

confidence: 99%

Section: Subsections Relevant For the Subjectmentioning

confidence: 99%

A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

Guo,

Lou,

Hou

et al. 2024

Front. Pharmacol.

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“…Recently, many herbal plant extracts and natural compounds were screened for promoting neurogenesis, with some of them being promising drug candidates [25][26][27]. In China, a number of herb ingredients known from Traditional Chinese Medicine (TCM) have a long history of use for improved learning and memory [28][29][30]. Therefore, these medicinal herbs provide efficient resources for drug discovery to promote neurogenesis.…”

Section: Discussionmentioning

confidence: 99%

<em>Poria cocos</em> (Schw.) Wolf, a Traditional Chinese Edible Medicinal Herb, Promotes Neuronal Differentiation and Maturation of Neural Stem/Progenitor Cells

Jiang,

Hu,

Qiu

et al. 2023

Preprint

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Neurogenesis in the adult brain plays a major role in the cognitive ability of animals including learning and memory. Poria cocos (Schw.) Wolf (P. cocos) has been known as a traditional Chinese edible medicinal herb with the potential effect to improve learning and memory. However, the effect mechanisms are still elusive. In this study, significant neuronal differentiation-promoting activities of the ethanol extracts of P. cocos (EEPC) were tested in Neuro-2a cells and mouse cortical neural stem/progenitor cells (NSPCs). Subsequently, 97 compounds of EEPC were identified using UHPLC-Q-Exactive-MS/MS. After investigation of neuronal differentiation-promoting activities of 4 major compounds (Ethyl palmitoleate, L-(-)-Arabitol, Choline and Adenosine), only Choline has significant neuronal differentiation-promoting activity. In summary, we investigated the neuronal differentiation-promoting activity and chemical compositions of EEPC, the study of the neuronal differentiation-promoting effect of ether extract of P. cocos indicated P. cocos’s positive effect on learning and memory functions. This is the first investigation of the neuronal differentiation-promoting effect of ether extract of P. cocos based on similar research references.

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“…The combination of the two has a better therapeutic effect. Sichuan lovage rhizome leads the medicine upward, to enable the medicine to reach the disease position and further play its role (23,24). Therefore, Shibing Xingnao Granules are effective in the treatment of VD.…”

Section: Discussionmentioning

confidence: 99%

Clinical effect of Shibing Xingnao granules on vascular dementia patients and its effect on serum neuronal apoptosis molecules

Liu¹,

Liu²,

Peng³

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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Effects of Dangshen Yuanzhi Powder on learning ability and gut microflora in rats with memory disorder

Cited by 10 publications

References 54 publications

A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

<em>Poria cocos</em> (Schw.) Wolf, a Traditional Chinese Edible Medicinal Herb, Promotes Neuronal Differentiation and Maturation of Neural Stem/Progenitor Cells

Clinical effect of Shibing Xingnao granules on vascular dementia patients and its effect on serum neuronal apoptosis molecules

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