Effects of Daily Kelp (Laminaria japonica) Intake on Body Composition, Serum Lipid Levels, and Thyroid Hormone Levels in Healthy Japanese Adults: A Randomized, Double-Blind Study

Aoe, Seiichiro; Yamanaka, Chiemi; Ohtoshi, Hirofumi; Nakamura, Fumiko; Fujiwara, Suguru

doi:10.3390/md19070352

Cited by 16 publications

(24 citation statements)

References 39 publications

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“…They reanalyzed the data [ 45 ] and found that phosphatidylcholines with diacyl links, lysophosphatidylcholine/diethanolamine with acyl linkages, and free fatty acids were improved after LJP use. Aoe et al conducted a double-blind clinical trial employing iodine-reduced powder of LJP and found that it significantly reduced the body fat percentage without affecting thyroid function [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

The Effect of Laminaria japonica on Metabolic Syndrome: A Systematic Review of Its Efficacy and Mechanism of Action

Lee

et al. 2022

Nutrients

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Metabolic syndrome (MetS) is a medical condition characterized by abdominal obesity, insulin resistance, high blood pressure, and hyperlipidemia. An increase in the incidence of MetS provokes an escalation in health care costs and a downturn in quality of life. However, there is currently no cure for MetS, and the absence of immediate treatment for MetS has prompted the development of novel therapies. In accordance with recent studies, the brown seaweed Laminaria japonica (LJP) has anti-inflammatory and antioxidant properties, and so forth. LJP contains bioactive compounds used as food globally, and it has been used as a medicine in East Asian countries. We conducted a systematic review to examine whether LJP could potentially be a useful therapeutic drug for MetS. The following databases were searched from initiation to September 2021: PubMed, Web of Science, EMBASE, and Cochrane Central Register of Controlled Trials Library. Clinical trials and in vivo studies evaluating the effects of LJP on MetS were included. LJP reduces the oxidative stress-related lipid mechanisms, inflammatory cytokines and macrophage-related chemokines, muscle cell proliferation, and migration. Bioactive-glucosidase inhibitors reduce diabetic complications, a therapeutic target in obesity and type 2 diabetes. In obesity, LJP increases AMP-activated protein kinase and decreases acetyl-CoA carboxylase. Based on our findings, we suggest that LJP could treat MetS, as it has pharmacological effects on MetS.

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Section: Resultsmentioning

confidence: 99%

The Effect of Laminaria japonica on Metabolic Syndrome: A Systematic Review of Its Efficacy and Mechanism of Action

Lee

et al. 2022

Nutrients

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“…A randomized case-control study for 8 weeks revealed that wakame (Undaria pinnatifida) intake (5 g/day) in brown algae significantly decreased blood pressure and hypercholesterolemia risk in 36 older Japanese individuals with hypertension [36]. A randomized, double-blind, and placebo-controlled intervention that advanced throughout the 8 weeks showed that iodine-reduced kelp (Laminaria japonica) powder supplementation decreased serum LDL-C levels in 50 overweight Japanese adults [37]. Furthermore, in an experimental animal study, the administration of seaweed-protein-derived hydrolysates decreased systolic blood pressure in 20-week-old spontaneously hypertensive rats [38].…”

Section: Discussionmentioning

confidence: 99%

Effect of the Interaction between Seaweed Intake and LPL Polymorphisms on Metabolic Syndrome in Middle-Aged Korean Adults

et al. 2023

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This study aimed to examine the effect of the interaction between seaweed (laver, kelp, and sea mustard) intake and lipoprotein lipase gene (LPL) rs17482735 genotypes on the incidence of metabolic syndrome (MetS). The Korean Genome and Epidemiology Study (KoGES) data of Korean adults aged 40–69 years were used in this study. Information on seaweed intake was obtained from the food frequency questionnaire. To investigate the interaction between seaweed intake and LPL rs17482735 genotypes on the incidence of MetS, multivariable Cox proportional hazard models were used after adjusting for confounding variables. There was no significant association in women, but men with TG and TT genotypes of rs17482753 had lower incidence of MetS (HR 0.83, 95% CI 0.71–0.95, p-value = 0.01), low HDL-cholesterol levels (HR 0.81, 95% CI 0.69–0.95, p-value = 0.01), high triglyceride levels (HR 0.83, 95% CI 0.70–0.99, p-value = 0.0471), and high blood pressure (HR 0.79, 95% CI 0.67–0.93, p-value = 0.004). Furthermore, the incidence of MetS was lower in men with the highest laver and total seaweed intake and TG and TT genotypes of rs17482735 (HR 0.60, 95% CI 0.43–0.84; HR 0.57, 95% CI 0.41–0.79, respectively). High seaweed intake was negatively associated with MetS, suggesting that LPL genetic variations, particularly in men, may be helpful in preventing MetS. These results demonstrate that seaweed intake considering LPL genotypes may be beneficial for preventing and treating MetS.

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“…A prospective study using meal supplements showed no significant difference in TSH levels between the body fat reduction group and other groups. 13) A controlled follow-up study reported that thyroxine treatment in patients with hypothyroidism increased the resting energy expenditure and decreased body weight, whereas fat mass was unchanged with weight loss, primarily due to the excretion of excess body water. 14) It is well established that thyroid hormone status is correlated with energy expenditure.…”

Section: Discussionmentioning

confidence: 99%

Short-term Changes in Thyroid-Stimulating Hormone Level after Body Fat Reduction via Partial Meal Replacement

et al. 2023

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Background: Serum thyroid-stimulating hormone (TSH) levels change during body weight reduction. However, the changes that occur during short-term body weight control interventions remain controversial. Thus, this study aimed to evaluate the changes in TSH levels according to body fat reduction.Methods: We performed a 3-month intervention study involving partial meal replacement. Forty-nine participants completed the study. Correlations between changes in TSH levels and other body composition parameters were determined. The subjects were divided into two groups according to their body fat reduction (>1 kg, n=20; <1 kg, n=29). The changes in metabolic parameters, including TSH levels, were compared. For significant values, a multivariate analysis was performed after adjustment to evaluate the relationship between TSH changes and body fat reduction.Results: The 3-month intervention caused favorable changes in body proportions and metabolic parameters. TSH levels changed significantly only after changes in total body fat, showing a partial correlation. Changes in TSH levels were significantly different between groups (P=0.014). Moreover, the change in TSH levels was significantly different after adjustment (P=0.012).Conclusion: A body fat reduction, especially >1 kg, can reduce serum TSH concentrations in subjects with metabolic syndrome after short-term body weight intervention.

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Effects of Daily Kelp (Laminaria japonica) Intake on Body Composition, Serum Lipid Levels, and Thyroid Hormone Levels in Healthy Japanese Adults: A Randomized, Double-Blind Study

Cited by 16 publications

References 39 publications

The Effect of Laminaria japonica on Metabolic Syndrome: A Systematic Review of Its Efficacy and Mechanism of Action

The Effect of Laminaria japonica on Metabolic Syndrome: A Systematic Review of Its Efficacy and Mechanism of Action

Effect of the Interaction between Seaweed Intake and LPL Polymorphisms on Metabolic Syndrome in Middle-Aged Korean Adults

Short-term Changes in Thyroid-Stimulating Hormone Level after Body Fat Reduction via Partial Meal Replacement

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