Pharmacological Research

2004

DOI: 10.1016/j.phrs.2004.02.003

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Effects of Dai-saiko-to (Da-Chai-Hu-Tang) on plasma lipids and atherosclerotic lesions in female heterozygous heritable Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits

Fumihiko Yoshie

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,

²

,

Yasuhiro Komatsu

³

et al.

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Daesiho-tang (Dst Daichaihu-tang1

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Cited by 18 publications

(17 citation statements)

References 33 publications

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“…Dried powders of herbal medicine [Shosaikoto (Xiao-Chai-Hu-Tang) (21), Daisaikoto (Da-Chai-Hu-Tang) (22), Saireito (Chai-Ling-Tang) (23), Saikokeishito (Chai-Hu-Gui-Zhi-Tang) (24), and Saikokaryukotsuboreito (Chai-Hu-Jia-Long-Gu-Mu-Li-Tang) (25)] and Scutellaria root extract were supplied by Tsumura Co., Ltd. (Tokyo, Japan). The herbal medicines contained several dried herbs in fixed proportions, as standardized by the Health, Labour and Welfare Ministry of Japan (Table I).…”

Section: Methodsmentioning

confidence: 99%

Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells

¹

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²

2016

International Journal of Oncology

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CD44 is a marker of cancer stem cells in head and neck squamous cell carcinoma, and CD44 expression is related to prognosis in cancer patients. We examined whether herbal medicine components affect CD44 expression and induce cancer cell apoptosis. Baicalin enhanced apoptosis with no effect on CD44 levels, while baicalein did not enhance apoptosis and upregulated CD44 in head and neck squamous cell carcinoma. Furthermore, baicalein induced phosphorylation of CHK1, as a marker of DNA damage response to S-to-G2/M phase arrest. Our results clearly demonstrated that baicalein enhanced expression of CD44 and accordingly enhanced the DNA damage response. These data suggest that induction of CD44 inhibited cancer cell induction of apoptosis by increasing the DNA damage response. Together, our findings suggest that CD44 expression in head and neck squamous cell carcinoma plays a role in enhancing the DNA damage response.

“…Dried powders of herbal medicine [Shosaikoto (Xiao-Chai-Hu-Tang) (21), Daisaikoto (Da-Chai-Hu-Tang) (22), Saireito (Chai-Ling-Tang) (23), Saikokeishito (Chai-Hu-Gui-Zhi-Tang) (24), and Saikokaryukotsuboreito (Chai-Hu-Jia-Long-Gu-Mu-Li-Tang) (25)] and Scutellaria root extract were supplied by Tsumura Co., Ltd. (Tokyo, Japan). The herbal medicines contained several dried herbs in fixed proportions, as standardized by the Health, Labour and Welfare Ministry of Japan (Table I).…”

Section: Methodsmentioning

confidence: 99%

Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells

¹

,

²

2016

International Journal of Oncology

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CD44 is a marker of cancer stem cells in head and neck squamous cell carcinoma, and CD44 expression is related to prognosis in cancer patients. We examined whether herbal medicine components affect CD44 expression and induce cancer cell apoptosis. Baicalin enhanced apoptosis with no effect on CD44 levels, while baicalein did not enhance apoptosis and upregulated CD44 in head and neck squamous cell carcinoma. Furthermore, baicalein induced phosphorylation of CHK1, as a marker of DNA damage response to S-to-G2/M phase arrest. Our results clearly demonstrated that baicalein enhanced expression of CD44 and accordingly enhanced the DNA damage response. These data suggest that induction of CD44 inhibited cancer cell induction of apoptosis by increasing the DNA damage response. Together, our findings suggest that CD44 expression in head and neck squamous cell carcinoma plays a role in enhancing the DNA damage response.

“…Hussain et al reported that DST ameliorates body weight gain in high-fat diet fed mice by regulating leptin and adiponectin gene expression in adipose tissue (11). In vivo and in vitro studies have reported that DST improves lipid metabolism by lowering hepatic triglyceride biosynthesis and by increasing low-density lipoprotein-receptor gene expression in hepatocytes (15,16). However, no clinical data for DST are available on obesity or NAFLD.…”

Section: Daesiho-tang (Dst Daichaihu-tangmentioning

confidence: 99%

Effect of Daesiho-tang on obesity with non-alcoholic fatty liver disease: A study protocol for a randomised, double-blind, placebo-controlled pilot trial

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³

et al. 2020

Preprint

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Background: The high prevalence of obesity and non-alcoholic fatty acid disease has become an important public health problem. Daesiho-tang (DST) is an herbal medicine widely used to treat obesity, metabolic syndrome and liver diseases. This pilot study will assess the feasibility of using DST in obese patients with a non-alcoholic fatty liver disease (NAFLD) prior to undertaking a full-scale clinical trial. Methods: This is a study protocol for a randomised, double-blind, parallel-group, stratified, placebo-controlled pilot trial. We will recruit a total of 60 participants with body mass index ≥ 25 kg/m2 and will have NAFLD. They will take either DST or placebo (3 g, three times daily) for 12 weeks with a 4-week follow-up period. The effects of DST will be evaluated by the mean change in body weight as the primary measurement and other secondary parameters (body composition, anthropometric measurements, blood tests, hepatic fat quantification through transient elastography and a physical symptoms questionnaire). Faecal samples will be collected before and after the intervention for a gut microbial analysis. Discussion: This study will explore the effect of DST on weight loss and obesity-related markers, along with NAFLD-related clinical parameters in obese patients with NAFLD to conduct further large-scale trials. Furthermore, it will provide insight into the DST pharmacological mechanism of action through a gut microbiome analysis Trial registration: Korean Clinical Trial Registry, KCT0003554. Registered on 25 February 2019, https://cris.nih.go.kr/cris/search/search_result_st01_en.jsp?seq=13379

“…Hussain et al reported that DST ameliorates body weight gain in mice fed a high-fat diet by regulating leptin and adiponectin gene expression in adipose tissue [11]. Authors of in vivo and in vitro studies have reported that DST improves lipid metabolism by lowering hepatic triglyceride biosynthesis and by increasing low-density lipoprotein receptor gene expression in hepatocytes [15,16]. However, no clinical data for DST are available regarding its use for obesity or NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Effect of Daesiho-tang on obesity with non-alcoholic fatty liver disease: a study protocol for a randomised, double-blind, placebo-controlled pilot trial

¹

,

²

,

³

et al. 2020

View full text Add to dashboard Cite

Background: The high prevalence of obesity and non-alcoholic fatty acid disease has become an important public health problem. Daesiho-tang (DST) is an herbal medicine widely used to treat obesity, metabolic syndrome and liver diseases. This pilot study will assess the feasibility of using DST in obese patients with a non-alcoholic fatty liver disease (NAFLD) prior to undertaking a full-scale clinical trial. Methods/design: This is a study protocol for a randomised, double-blind, parallel-group, stratified, placebo-controlled pilot trial. We will recruit a total of 60 participants with NAFLD who have a body mass index ≥ 25 kg/m 2 . They will take either DST or placebo (3 g, three times daily) for 12 weeks with a 4-week follow-up period. The effects of DST will be evaluated by the mean change in body weight as the primary measurement and other secondary parameters (body composition, anthropometric measurements, blood tests, hepatic fat quantification through transient elastography and a physical symptoms questionnaire). Faecal samples will be collected before and after the intervention for a gut microbial analysis.Discussion: In anticipation of conducting further large-scale trials, in this study we will explore the effect of DST on weight loss and obesity-related markers, along with NAFLD-related clinical parameters, in obese patients with NAFLD. Furthermore, it will provide insight into the DST pharmacological mechanism of action through a gut microbiome analysis.

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