Effects of D1 and D2 antagonists on the transient increase of dopamine release by dopamine agonists by means of brain dialysis

Kurata, Kouichi; Shibata, Ryoko

doi:10.1016/0304-3940(91)90061-w

Cited by 15 publications

(12 citation statements)

References 19 publications

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“…Given the systemic application of the D1-R antagonist, we could not distinguish brain region and subcellular localization specific effects. Nevertheless, the very same D1-R antagonist we employed here, SCH23390, has been shown to reduce dopamine (Steketee, 1998; Kurata & Shibata, 1991) as well as serotonin release (Darbin et al, 2010) in mammals, results that are compatible with our finding of reduced DOPAC and 5HIAA levels in zebrafish. Furthermore, the level of neurotransmitter production has been shown to correlate with the level of their metabolites in mammals (Diop et al, 1988), which again is in line with our finding of reduced dopamine levels in response to the systemic D1-R antagonist treatment in zebrafish.…”

Section: Discussionsupporting

confidence: 89%

“…Receptor occupancy, drug absorption, distribution, metabolism and excretion (ADME) studies have not been carried out in zebrafish for this particular drug, but based upon the mammalian literature (e.g. Cameron & Williams, 1993; Darbin et al, 2010; Steketee, 1998; Kurata & Shibata, 1991 and references therein) as well as on our own pilot behavioral studies, we found the 30 min exposure period to be sufficiently long for the drug to reach the zebrafish brain and exert behavioral effects. We also found the one hour long acclimation period to be sufficient for the fish to recover from any potential negative (fear inducing) consequences of the dosing procedure but not too long for the drug to wash out.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, SCH23390 has been thoroughly investigated for its psychopharmacological properties in mammals (e.g. Cameron & Williams, 1993; Darbin et al, 2010; Steketee, 1998; Kurata & Shibata, 1991). Last, this drug is water soluble and thus it could be administered to zebrafish by simple immersion of the subject in the drug solution.…”

Section: Introductionmentioning

confidence: 99%

“…Although both of these outcomes are possible, antagonism of D1-R using the compound we employed here, i.e. SCH23390, has been shown to reduce dopamine (Steketee, 1998; Kurata & Shibata, 1991) as well as serotonin release (Darbin et al, 2010) in mammals. It is also important to note that the level of neurotransmitter production has been shown to correlate with the level of their metabolites (Diop et al, 1988).…”

Section: Introductionmentioning

confidence: 99%

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Dopamine receptor antagonism disrupts social preference in zebrafish: a strain comparison study

2012

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Zebrafish form shoals in nature and in the laboratory. The sight of conspecifics has been found reinforcing in zebrafish learning tasks. However, the mechanisms of shoaling, and those of its reinforcing properties, are not known. The dopaminergic system has been implicated in reward among other functions and it is also engaged by drugs of abuse as shown in a variety of vertebrates including zebrafish. The ontogenetic changes in dopamine levels and, to a lesser degree, in serotonin levels, have been found to accompany the maturation of shoaling in zebrafish. Thus, we hypothesized that the dopaminergic system may contribute to shoaling in zebrafish. To test this we employed a D1-receptor antagonist and quantified behavioral responses of our subjects using a social preference (shoaling) paradigm. We found significant reduction of social preference induced by the D1-R antagonist, SCH23390, in the AB strain of zebrafish, an alteration that was not accompanied by changes in motor function or vision. We also detected D1-R antagonist induced changes in the level of dopamine, DOPAC, serotonin and 5HIAA, respectively, in the brain of AB zebrafish as quantified by HPLC with electrochemical detection. We found the antagonist induced behavioral changes to be absent and the levels of these neurochemicals to be lower in another zebrafish population, SF, demonstrating naturally occurring genetic variability in these traits. We conclude that this variability may be utilized to unravel the mechanisms of social behavior in zebrafish, a line of research that may be extended to other vertebrates including our own species.

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Section: Discussionsupporting

confidence: 89%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dopamine receptor antagonism disrupts social preference in zebrafish: a strain comparison study

2012

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“…Not surprisingly, the reverse microdialysis drug delivery method has provided a powerful technique for the study of local drug action and been used extensively in the brain and other tissues and has been thoroughly reviewed in the literature (Hocht et al, 2004, 2007; Plock and Kloft, 2005). The drug concentrations used in this study are 10-fold higher than those generally found in brain slice superfusion experiments, and were chosen to compensate for the spatial and temporal limitations associated with drug administration by reverse microdialysis, usually done in other studies (Hoebel et al, 1983; Johnson and Justice, 1983; Kurata and Shibata, 1991; Zornoza et al, 2005b; Rodriguez et al, 2008). …”

Section: Discussionmentioning

confidence: 99%

Local Hippocampal Methamphetamine-Induced Reinforcement

Ricoy

Martinez

2009

Front. Behav. Neurosci.

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Drug abuse and addiction are major problems in the United States. In particular methamphetamine (METH) use has increased dramatically. A greater understanding of how METH acts on the brain to induce addiction may lead to better therapeutic targets for this problem. The hippocampus is recognized as an important structure in learning and memory, but is not typically associated with drug reinforcement or reward processes. Here, the focus is on the hippocampus which has been largely ignored in the addiction literature as compared to the nucleus accumbens (NAc), ventral tegmental area (VTA), and prefrontal cortex (PFC). The results show that METH administered unilaterally via a microdialysis probe to rats’ right dorsal hippocampus will induce drug-seeking (place preference) and drug-taking (lever-pressing) behavior. Furthermore, both of these responses are dependent on local dopamine (DA) receptor activation, as they are impaired by a selective D1/D5 receptor antagonist. The results suggest that the hippocampus is part of the brain's reward circuit that underlies addiction.

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Dopamine D1 receptor blockade impairs alcohol seeking without reducing dorsal striatal activation to cues of alcohol availability

Fanelli

Robinson

2015

Brain and Behavior

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IntroductionAlcohol-associated cues activate both ventral and dorsal striatum in functional brain imaging studies of heavy drinkers. In rodents, alcohol-associated cues induce changes in neuronal firing frequencies and increase dopamine release in ventral striatum, but the impact of alcohol-associated cues on neuronal activity in dorsal striatum is unclear. We previously reported phasic changes in action potential frequency in the dorsomedial and dorsolateral striatum after cues that signaled alcohol availability, prompting approach behavior.MethodsWe investigated the hypothesis that dopamine transmission modulates these phasic firing changes. Rats were trained to self-administer alcohol, and neuronal activity was monitored with extracellular electrophysiology during “anticipatory” cues that signaled the start of the operant session. Sessions were preceded by systemic administration of the D1-type dopamine receptor antagonist SCH23390 (0, 10, and 20 μg/kg).ResultsSCH23390 significantly decreased firing rates during the 60 s prior to cue onset without reducing phasic excitations immediately following the cues. While neuronal activation to cues might be expected to initiate behavioral responses, in this study alcohol seeking was reduced despite the presence of dorsal striatal excitations to alcohol cues.ConclusionsThese data suggest that D1 receptor antagonism reduces basal firing rates in the dorsal striatum and modulates the ability of neuronal activation to “anticipatory” cues to initiate alcohol seeking in rats with an extensive history of alcohol self-administration.

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Effects of D1 and D2 antagonists on the transient increase of dopamine release by dopamine agonists by means of brain dialysis

Cited by 15 publications

References 19 publications

Dopamine receptor antagonism disrupts social preference in zebrafish: a strain comparison study

Dopamine receptor antagonism disrupts social preference in zebrafish: a strain comparison study

Local Hippocampal Methamphetamine-Induced Reinforcement

Dopamine D1 receptor blockade impairs alcohol seeking without reducing dorsal striatal activation to cues of alcohol availability

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