Effects of d-ribose on human erythrocytes: Non-enzymatic glycation of hemoglobin, eryptosis, oxidative stress and energy metabolism

Zhang, Zehong; Tai, Yu Tzu; Li, Zhi; Pu, Yunxia; An, Liang; Li, Xiaojing; Li, Lili; Wang, Yaqi; Yang, Zhongbin; Duan, Chao; Hou, Kezuo; Zhang, Qing; Ren, Fuyu; Ma, Qiang; Yan, Shuicheng

doi:10.1016/j.bcmd.2023.102725

Cited by 4 publications

(4 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, d -ribose, a five-carbon furanose, possesses strong reducing properties [ 75 , 76 , 77 ] and is ubiquitous. It plays a vital role in organismal growth and development because it is an essential component of RNA, nucleotides, B vitamins, and several coenzymes [ 78 , 79 ]. Collectively, these differential metabolites may explain the differences between M. strigata and P. viridis in interspecies competition.…”

Section: Discussionmentioning

confidence: 99%

Integrated Metagenomic and Metabolomic Analysis on Two Competing Mussels, Mytella strigata and Perna viridis, in China

Zuo,

Ma,

et al. 2024

Animals

View full text Add to dashboard Cite

Biological invasion is a primary direct driver of biodiversity loss. Recently, owing to exploitation competition with an invasive mussel, Mytella strigata (Hanley, 1843), there has been a drastic decrease in the population of native Perna viridis (Linnaeus, 1758) in several western Pacific regions. In the present study, intestinal microbiota, metabolome, and key digestive enzyme activities were compared between the two competing mussels, M. strigata and P. viridis, to elucidate the differences in intestinal microbiota and metabolic points. We observed that Proteobacteria, Firmicutes, and Bacteroidota were the three predominant bacterial phyla in the two species. The relative abundance of Bacteroidota related to carbohydrate-degrading ability was significantly higher in M. strigata than in P. viridis. Compared to P. viridis, different metabolites including maltose and trehalose were enriched in M. strigata. Lastly, higher carbohydrases activities of alpha-amylase, cellulase, and xylanase were observed in M. strigata than in P. viridis. These differences might play an important role in the adaptation process of M. strigata to the new environment. This study provides important basic knowledge for investigating the competition between M. strigata and P. viridis in terms of food resources utilization.

show abstract

Section: Discussionmentioning

confidence: 99%

Integrated Metagenomic and Metabolomic Analysis on Two Competing Mussels, Mytella strigata and Perna viridis, in China

Zuo,

Ma,

et al. 2024

Animals

View full text Add to dashboard Cite

show abstract

“…Increased HbA1c levels are associated with higher risks of diabetic complications. [30] Hyperglycemia induces the production of ROS within RBCs through various pathways, such as the polyol pathway, advanced glycation end products (AGEs) formation, and increased mitochondrial oxidative stress. [31] Prolonged exposure to high glucose impairs the antioxidant defense mechanisms in RBCs, leading to a reduction in antioxidant enzymes (e.g., superoxide dismutase, catalase) and decreased levels of intracellular antioxidants (e.g., glutathione).…”

Section: Role Of Hyperglycemia In Inducing Oxidative Stress and Impac...mentioning

confidence: 99%

Red blood cells as biomarkers and mediators in complications of diabetes mellitus: A review

Obeagu

2024

Medicine

View full text Add to dashboard Cite

Red blood cells (RBCs), traditionally recognized for their oxygen transport role, have garnered increasing attention for their significance as crucial contributors to the pathophysiology of diabetes mellitus. In this comprehensive review, we elucidate the multifaceted roles of RBCs as both biomarkers and mediators in diabetes mellitus. Amidst the intricate interplay of altered metabolic pathways and the diabetic milieu, RBCs manifest distinct alterations in their structure, function, and lifespan. The chronic exposure to hyperglycemia induces oxidative stress, leading to modifications in RBC physiology and membrane integrity. These modifications, including glycation of hemoglobin (HbA1c), establish RBCs as invaluable biomarkers for assessing glycemic control over extended periods. Moreover, RBCs serve as mediators in the progression of diabetic complications. Their involvement in vascular dysfunction, hemorheological changes, and inflammatory pathways contributes significantly to diabetic microangiopathy and associated complications. Exploring the therapeutic implications, this review addresses potential interventions targeting RBC abnormalities to ameliorate diabetic complications. In conclusion, comprehending the nuanced roles of RBCs as biomarkers and mediators in diabetes mellitus offers promising avenues for enhanced diagnostic precision, therapeutic interventions, and improved patient outcomes. This review consolidates the current understanding and emphasizes the imperative need for further research to harness the full potential of RBC-related insights in the realm of diabetes mellitus.

show abstract

“…Notably, D-ribose glycation of serum proteins was both more pronounced and faster compared to D-glucose, further underscoring D-ribose’s heightened nonenzymatic glycation capability. Multiple studies have pointed out that D-ribose can interact with Hb [ 6 , 38 – 40 ], myoglobin [ 34 ], bovine serum albumin (BSA) [ 35 , 37 , 41 ], fibrinogen [ 42 ], β2-microglobulin [ 43 ], α-synuclein [ 44 ], and human immunoglobulin-G [ 45 ], thereby initiating rapid nonenzymatic glycation reactions and protein aggregation. Glycation with D-ribose leads to structural alterations in native Hb [ 46 ].…”

Section: Effect Of Exogenous D-ribose On Cellsmentioning

confidence: 99%

“…A subsequent series of in vitro experiments has substantiated that elevated concentrations of D-ribose exert detrimental effects on peripheral blood mononuclear cells, human neuroblastoma SY5Y cells, glomerular interstitial cells SV40 MES 13, human glioma cells U251, human astroblastoma cells U87MG, renal mesangial cells, and Chinese hamster ovary (CHO) cells [ 38 , 54 , 55 ]. The toxicity mechanism of D-ribose is primarily associated with AGEs, which comprise a diverse and highly reactive group of compounds.…”

Section: Effect Of Exogenous D-ribose On Cellsmentioning

confidence: 99%

D-ribose metabolic disorder and diabetes mellitus

Tai,

Zhang,

Liu

et al. 2024

Mol Biol Rep

Self Cite

View full text Add to dashboard Cite

D-ribose, an ubiquitous pentose compound found in all living cells, serves as a vital constituent of numerous essential biomolecules, including RNA, nucleotides, and riboflavin. It plays a crucial role in various fundamental life processes. Within the cellular milieu, exogenously supplied D-ribose can undergo phosphorylation to yield ribose-5-phosphate (R-5-P). This R-5-P compound serves a dual purpose: it not only contributes to adenosine triphosphate (ATP) production through the nonoxidative phase of the pentose phosphate pathway (PPP) but also participates in nucleotide synthesis. Consequently, D-ribose is employed both as a therapeutic agent for enhancing cardiac function in heart failure patients and as a remedy for post-exercise fatigue. Nevertheless, recent clinical studies have suggested a potential link between D-ribose metabolic disturbances and type 2 diabetes mellitus (T2DM) along with its associated complications. Additionally, certain in vitro experiments have indicated that exogenous D-ribose exposure could trigger apoptosis in specific cell lines. This article comprehensively reviews the current advancements in D-ribose’s digestion, absorption, transmembrane transport, intracellular metabolic pathways, impact on cellular behaviour, and elevated levels in diabetes mellitus. It also identifies areas requiring further investigation.

show abstract

Effects of d-ribose on human erythrocytes: Non-enzymatic glycation of hemoglobin, eryptosis, oxidative stress and energy metabolism

Cited by 4 publications

References 43 publications

Integrated Metagenomic and Metabolomic Analysis on Two Competing Mussels, Mytella strigata and Perna viridis, in China

Integrated Metagenomic and Metabolomic Analysis on Two Competing Mussels, Mytella strigata and Perna viridis, in China

Red blood cells as biomarkers and mediators in complications of diabetes mellitus: A review

D-ribose metabolic disorder and diabetes mellitus

Contact Info

Product

Resources

About