Effects of d,l-fenfluramine on aggressive and impulsive responding in adult males with a history of conduct disorder

Cherek, Don R.; Lane, Scott D.

doi:10.1007/pl00005493

Cited by 65 publications

(43 citation statements)

References 70 publications

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“…It is consistent with other work showing that ATD affects impulsive behavior only in certain individuals (Cherek and Lane, 1999;LeMarquand et al, 1999;Bjork et al, 2000;Marsh et al, 2002;Swann et al, 2002; but see Crean et al, 2002).…”

Section: Discussionsupporting

confidence: 92%

“…CSF concentrations of the 5-HT metabolite 5-HIAA correlate inversely with impulsive behaviors in many neuropsychiatric and personality disorders including aggressive, conduct, and attention-deficit/hyperactivity disorders (Evenden, 1999). Furthermore, recent studies with human volunteers have found that ATD increases impulsive and aggressive behavior, although these effects appear to depend on individual differences in impulsive personality traits (Cherek and Lane, 1999;LeMarquand et al, 1999;Dougherty et al, 1999;Bjork et al, 2000;Marsh et al, 2002;Crean et al, 2002). Findings from studies with clinical human populations are corroborated by an extensive number of animal studies, which suggest that impulsive choice in delaydiscounting paradigms and premature responding in choice reaction-time tasks implicate changes in the 5-HT system (Wogar et al, 1993;Harrison et al, 1997a, b;Puumala and Sirvio, 1998;Koskinen et al, 2000;Mobini et al, 2000;Dalley et al, 2002;Passetti et al, 2003;Winstanley et al, 2003;Liu et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Tryptophan Depletion Disrupts the Motivational Guidance of Goal-Directed Behavior as a Function of Trait Impulsivity

Cools

Blackwell

Clark

et al. 2005

Neuropsychopharmacol

143

145

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Serotonin (5-HT) is well known to affect the motivational properties of stimuli predictive of rewards as well as the inhibitory control of behavior. Here, central 5-HT depletion was induced by the acute tryptophan (TRP) depletion (ATD) procedure in young healthy volunteers to examine the role of 5-HT in motivated action and prepotent response inhibition. A novel reaction-time task, tailored to individual differences in general cognitive speed, was employed to measure the guidance of behavior by motivationally relevant signals predictive of reinforcement likelihood, while the stop-signal reaction-time task was used to measure response inhibition. Following the TRP-balancing control drink, cues predictive of high-reinforcement certainty induced faster, but less accurate responses compared with cues predictive of lower reinforcement certainty. Depletion of central 5-HT modulated this coupling between motivation and action by slowing responses and increasing accuracy as a function of incentive certainty. These effects of ATD on motivated action correlated highly with individual differences in the personality trait of Nonplanning Impulsiveness (Barratt Impulsivity Scale (BIS-11)), so that strongest effects on motivated action were observed in high-impulsive individuals. By contrast, ATD left unaltered the ability to inhibit prepotent responses. Our findings may have implications for a variety of neuropsychiatric disorders including impulsive aggressive disorders and depression.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Tryptophan Depletion Disrupts the Motivational Guidance of Goal-Directed Behavior as a Function of Trait Impulsivity

Cools

Blackwell

Clark

et al. 2005

Neuropsychopharmacol

143

145

View full text Add to dashboard Cite

show abstract

“…Some studies find that antisocial behavioral patterns and impulsivity may be mediated via a serotonergic mechanism (Virkkunen et al 1987;Cherek and Lane 1999), and others relate impulsivity and ASP to prefrontal cortex abnormalities (Hare 1984;Cloninger 1987;O'Connor et al 1994;Bauer 1997Bauer , 2001Costa et al 2000). High discounting may also have a genetic basis.…”

Section: Discussionmentioning

confidence: 94%

Discounting of delayed rewards in substance abusers: relationship to antisocial personality disorder

2002

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“…However, in our study, responding increased across the three daily sessions. Furthermore, past research suggests that PSAP responding does not significantly decrease from day one to day two [Cherek and Lane, 1999;Cherek et al, 2002a]. That being stated, future studies may examine this possibility by altering the order of presentation of escape and no escape availability.…”

Section: Discussionmentioning

confidence: 99%

Providing an escape option reduces retaliatory aggression

2005

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The purpose of this study was to examine whether providing an explicit means to escape future attacks by a provocative fictitious participant reduces retaliatory aggression. Using a laboratory measure of aggression (the Point Subtraction Aggression Paradigm), 25 participants were given the opportunity to earn points with monetary value on a fixed ratio (FR) 100 schedule, and to subtract points from a fictitious participant on an FR 10 schedule. Aggressive responding was defined as the number of point subtraction responses by the participant. Aggressive responding also produced intervals free from further attack by the fictitious participant. Provocation was manipulated by having the fictitious person subtract points from the participant. Each participant next completed the same task with an explicit FR 10 escape response option added. The escape option produced intervals free from attack identical to the aggressive option, but without taking points away from the fictitious participant. Results indicate that the availability of an escape response attenuated aggressive behavior in response to provocation.

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Effects of d,l-fenfluramine on aggressive and impulsive responding in adult males with a history of conduct disorder

Abstract: Release of serotonin and/or reuptake blockade by d,l-fenfluramine is the possible mechanism for reductions in aggression and impulsivity. These results are consistent with a large body of data linking reduced serotonin function and aggressive behavior and impulsivity.

Cited by 65 publications

References 70 publications

Tryptophan Depletion Disrupts the Motivational Guidance of Goal-Directed Behavior as a Function of Trait Impulsivity

Tryptophan Depletion Disrupts the Motivational Guidance of Goal-Directed Behavior as a Function of Trait Impulsivity

Discounting of delayed rewards in substance abusers: relationship to antisocial personality disorder

Providing an escape option reduces retaliatory aggression

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