Effects of D-allulose on glucose metabolism after the administration of sugar or food in healthy dogs

Abstract

D-allulose is a C-3 epimer of D-fructose and has recently been investigated for its hypoglycemic effects. In the present study, the effects of D-allulose on glucose metabolism were evaluated in healthy dogs administrated sugar or food. The oral administrations of D-allulose decreased plasma glucose concentrations after oral glucose or maltose administration, with a diminished plasma insulin rise. The glucose suppressive effect of D-allulose was also observed after intravenous glucose administrations without increase in plasma insulin concentration. In contrast, D-allulose showed no effect on plasma glucose and insulin concentrations after feeding. The present results suggest that D-allulose administration may be beneficial in dogs with impaired glucose tolerance. Further studies investigating the therapeutic efficacy of D-allulose in diabetic dogs are required.

The long-term safety of D-allulose administration in healthy dogs

“…In the present study, D-allulose administration did not affect the results of the glucose tolerance test. In contrast, a previous study has reported that a single administration of D-allulose (0.2 g/kg), 60 min before the intravenous glucose injection significantly lowers plasma glucose and insulin concentrations in dogs [ 19 ]. In the present study, the postadministration experiment was conducted one day after termination of D-allulose administration to evaluate the long-term cumulative effect of D-allulose on glucose metabolism.…”

“…The reported effects of D-allulose in rodents and humans may help the management of these pathologic conditions in dogs. In fact, D-allulose has been shown to suppress the rise in blood glucose following oral or intravenous glucose administration in dogs [ 19 ].…”

“…D-allulose was provided by the Kagawa University Rare Sugar Research Center, Japan. The dose rate of D-allulose was determined according to a previous study [ 19 ]. Food consumption, feces characteristics, activity, and clinical signs, if any, were recorded daily.…”

“…The biochemical parameters were measured by an automated biochemical analyzer (Labospect 003; Hitachi High-Technologies, Tokyo, Japan). Plasma insulin concentration was assayed using the LBIS dog insulin enzyme-linked immunosorbent assay kit (Shibayagi, Gunma, Japan) [ 19 ].…”