1990
DOI: 10.1089/jir.1990.10.379
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Effects of Cytokines from Virus-Induced Human Lymphoblasts on the Growth and Viability of the Promyelocytic Leukemia Cell Line HL-60

Abstract: Cells of the human B-cell lymphoblastic leukemia line, BALL-1, were stimulated with Sendai virus. It is shown that the crude culture supernatants contain not only interferon-alpha (IFN-alpha) and tumor necrosis factor-alpha (TNF-alpha) but also other cytokines, here collectively termed 'X' cytokines. The latter did not affect the cytostatic or differentiation-inducing effect of IFN-alpha but synergistically increased the cytotoxicity of TNF-alpha.

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