Effects of cytokines and nitric oxide on myocardial E-C coupling

Haque, Raziul; Kan, Hong; Finkel, Mitchell S.

doi:10.1007/978-3-642-47070-7_10

Cited by 6 publications

(7 citation statements)

References 76 publications

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“…In addition, oxidative stress has detrimental effects on cardiac function since oxygen free radicals depress excitation-contraction coupling [39]. We measured three different markers of oxidative excess: TBARS and 8-isoprostaglandin F 2α , indices of lipid peroxidation, and serum nitrotyrosine, an indicator of tyrosine nitrosylation of proteins, a redoxsensitive process.…”

Section: Discussionmentioning

confidence: 99%

Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support

et al. 2006

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In the present study, we evaluated circulating pro-inflammatory mediators and markers of oxidative stress in patients with decompensated CHF (congestive heart failure) and assessed whether clinical recompensation by short-term inotropic therapy influences these parameters. Patients with worsening CHF (n=29, aged 61.9+/-2.7 years), NYHA (New York Heart Association) class III-IV, and left ventricular ejection fraction of 23.7+/-1.8% were studied. Controls comprised age-matched healthy volunteers (n=15; 54.1+/-3.2 years). Plasma levels of cytokines [IL (interleukin)-6 and IL-18], chemokines [MCP-1 (monocyte chemotactic protein-1)], adhesion molecules [sICAM (soluble intercellular adhesion molecule), sE-selectin (soluble E-selectin)], systemic markers of oxidation [TBARS (thiobarbituric acid-reactive substances), 8-isoprostaglandin F(2alpha) and nitrotyrosine] and hs-CRP (high-sensitivity C-reactive protein) were measured by ELISA and colorimetric assays at admission and 30 days following 72-h milrinone (n=15) or dobutamine (n=14) infusion. Plasma IL-6, IL-18, sICAM, E-selectin, hs-CRP and oxidative markers were significantly higher in patients on admission before inotropic treatment compared with controls (P<0.05). Short-term inotropic support improved clinical status as assessed by NYHA classification and by the 6-min walk test and significantly decreased plasma levels of IL-6, IL-18, sICAM, hs-CRP and markers of oxidation (P<0.05) at 30 days. The effects of milrinone and dobutamine were similar. In conclusion, our results demonstrate that patients with decompensated CHF have marked systemic inflammation and increased production of oxygen free radicals. Short-term inotropic support improves functional status and reduces indices of inflammation and oxidative stress in patients with decompensated CHF.

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Section: Discussionmentioning

confidence: 99%

Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support

et al. 2006

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“…High levels of cGMP leads to elevated activity of PKG that inhibits the L-type calcium channel and PDE II that hydrolyzes cAMP resulting in decreased cAMP levels (Juilfs et al, 1999). High levels of cGMP decrease the affinity of calcium to the myosin and mitochondrial activity in myocytes (Haque et al, 1998). It is suggested that these effects could account for the rapidly increased contractile function during inhibition of iNOS function.…”

Section: Mechanisms Of No Inhibition Of Cardiac Functionmentioning

confidence: 98%

Modulation of iNOS activity in age-related cardiac dysfunction

2004

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“…Cytokines also interfere with heart electrophysiology, as they alter electromechanical coupling contributing to the reversible myocardial depression and b-adrenergic desensitisation observed in diverse clinical conditions [52]. The plasma of cirrhotic patients is also rich in bile salts [53], which may contribute to the altered membrane fluidity of myocytes [54] seen in experimental biliary cirrhosis [39].…”

Section: Potential 'Cardiotoxins' Responsible For Electrophysiologicamentioning

confidence: 99%