Effects of cypermethrin on antioxidant enzymes and lipid peroxidation of Lake Van fish (<i>Alburnus tarichi</i>)

Özok, Necati

doi:10.1080/01480545.2019.1660363

Cited by 23 publications

(8 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was no significant difference in the brain MDA concentration, and the activities of brain SOD, CAT and GPx in the experimental groups (Table 2). The brain MDA concentration of the CYP group was not overtly increased in accordance with the reports of other researchers (Sankar et al, 2012;Özok et al, 2019). This may be due to the fact that CYP elicits variable responses depending upon the doses, time, routes of exposure, strain, age, gender and species of animals across multiple studies (Singh et al, 2012).…”

Section: Resultssupporting

confidence: 87%

Evaluation of the Impacts of Taurine on Oxidative Stress Indices in Sera and Brain of Rats Exposed to Cypermethrin

Akande¹,

Okoronkwo²,

Abalaka³

et al. 2021

jasem

View full text Add to dashboard Cite

Cypermethrin is a pyrethroid insecticide applied for pest control on animals and the environment. Taurine is a putative antioxidant and bioprotective amino acid. The purpose of the research was to evaluate the impacts of taurine on oxidative stress indices in the sera and brains of rats exposed to cypermethrin. Forty rats were assigned to five groups of eight rats each. Distilled water was given to the first group, while the second group received soya oil (2 ml/kg). Cypermethrin (20 mg/kg) was administered to the third group. The Taurine50+Cypermethrin group received taurine (50 mg/kg) and cypermethrin, while the Taurine100+Cypermethrin group was administered with taurine (100 mg/kg) and Cypermethrin. The treatments were given once daily by oral gavage for 35 days. Sera were obtained from the blood samples of the rats after the completion of the study for the determination of the oxidative stress indices (malondialdehyde concentration and the activities of antioxidant enzymes). Oxidative stress indices were analysed in the brains. Taurine significantly (P< 0.05) augmented the superoxide dismutase activity in the sera. However, other oxidative stress indices were not ameliorated by taurine in the sera and the brains. Cypermethrin (20 mg/kg) did not overtly evoke oxidative stress in the sera and the brains of the rats in this study, probably because it is a moderately toxic insecticide. This is the first study that has investigated the effects of taurine on cypermethrin toxicity. Further research is warranted to expound the mechanisms of action of taurine and cypermethrin in biological systems. Keywords: Taurine, Cypermethrin, Serum, Brain, Oxidative Stres

show abstract

Section: Resultssupporting

confidence: 87%

Evaluation of the Impacts of Taurine on Oxidative Stress Indices in Sera and Brain of Rats Exposed to Cypermethrin

Akande¹,

Okoronkwo²,

Abalaka³

et al. 2021

jasem

View full text Add to dashboard Cite

show abstract

“…The considerable increase in GPx activity on day 1 and day 7 of treatment ( p 0.05) at all concentrations of SDS, CPC and SLES in the present study indicated that GPx probably plays a pivotal role in antioxidant defence by protecting the organism against peroxidation of lipid (Xiong et al, 2014). However, a significant decrease in GPx activity at 2.45 mg/L of SDS as well as 0.036 mg/L of CPC and.65 mg/L and 4.96 mg/L of SLES in comparison with the control ( p < 0.05) at the end of the exposure period (14 days), may be due to inability of the antioxidant defence system to inhibit the generation of ROS induced by the toxicant (Özok, 2020). A similar alteration was reported in oligochaete worm Tubifex during 15 days of exposure to thallium (Kiliç & Kiliç, 2017).…”

Section: Resultsmentioning

confidence: 99%

Acute toxicity and impact of sublethal exposure to commonly used surfactants sodium dodecyl sulphate, cetylpyridinium chloride and sodium laureth sulphate on oxidative stress enzymes in oligochaete worm Branchiura sowerbyi (Beddard, 1892)

Bhattacharya

Chatterjee

et al. 2021

Aquac Res

View full text Add to dashboard Cite

The current study aimed to determine the detrimental effects of sodium dodecyl sulphate (SDS), cetylpyridinium chloride (CPC), and sodium laureth sulphate (SLES) on survival rate and oxidative stress enzymes in Branchiura sowerbyi (Beddard, 1892). The 96 h LC50 values of SDS, CPC and SLES to Branchiura sowerbyi were estimated to be 8.27, 0.12 and 19.58 mg/L, respectively. Moreover, surfactant toxicity was projected using general threshold survival models (GUTS) in terms of required data sets and fit performance. The result suggested that GUTS‐IT (individual tolerance) model can better predict the survival rate observed in Branchiura sowerbyi for surfactant exposure than the GUTS‐SD (stochastic death) model. Sublethal levels of SDS, CPC and SLES (10% and 30% of the 96 h LC50 value) elicited substantial changes in oxidative stress enzymes over the 14‐day exposure period. Superoxide dismutase (SOD), reduced glutathione (GSH), glutathione S‐transferase (GST) and glutathione peroxidase (GPx) demonstrated a significant increasing trend initially followed by a subsequent declining trend, but the levels of catalase (CAT), as well as malondialdehyde (MDA), increased significantly throughout the periods of exposure. The consequences of SDS, CPC and SLES on Branchiura sowerbyi were evaluated using a correlation matrix, principal component analysis, and integrated biomarker response assessment. These findings suggest that SDS, CPC and SLES exposure detrimentally affect survival rate and alter the levels of oxidative stress enzymes in Branchiura sowerbyi.

show abstract

“…Thereafter, a static lethal toxicity assay was conducted to determine the 96-hour LC50. The choice of static non-renewal experimental design was based on the knowledge that the half-life of most pyrethroid pesticides is longer than 48 hours [27] and the desire to accommodates time-dependent degradation of the pesticides. Four different concentrations of pesticides, 0.75 µg/L cypermethrin and 6.25 µg/L dimethoate (Group II); 0.9 µg/L cypermthrin and 7.5 µg/L (Group III), 1.13 µg/L of cypermethrin and 9.3 µg/L of dimethoate (Group IV) and control, no pesticide (Group I) were used for the lethal assay.…”

Section: Experimental Designmentioning

confidence: 99%

Combinations of cypermethrin and dimethoate alter behavior, hematology and histology of African Catfish, Clarias gariepinus

Okogwu¹,

Elebe²,

Nwonumara³

2022

Environ Anal Health Toxicol

View full text Add to dashboard Cite

Cypermethrin and dimethoate are pesticides frequently used in agriculture to eliminate pests. Contemporaneity of these and other pesticides in commercial preparations and several aquatic ecosystems is well known, though poorly studied. This study aims to evaluate the effect of sublethal concentrations of combinations of cypermethrin and dimethoate on juvenile catfish, Clarias gariepinus, given that the pesticides concomitantly occur in the floodplains were the fish breed. Behavioral, hematological and histopathological changes in juvenile fish exposed to sublethal concentrations were monitored for 96 hours. Pesticide exposed fish exhibited abnormal behaviors such as erratic swimming, frequent air gulping, sudden jerk movement and rapid opercula movement and these were more pronounced in higher concentrations. Significant reductions in erythrocytes (0.83-20.94%), hemoglobin (4.12-29.23%) and PVC (7.14-28.57%) and increase in leucocytes (4.84-9.32%) were observed (p<0.05). Mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH) and mean cell volume (MCV) reduced significantly in the exposed groups compared to the control. Infiltration of inflammatory cells, distortion of cell architecture, hemorrhage and necrosis were the observed histopathological damages in the heart, brain, gill, liver, kidney and fin of exposed fish. These pathological damages were more severe than previously reported for either chemical. Therefore, the use of these chemicals in agriculture should be regulated, especially near fish breeding sites.

show abstract

Effects of cypermethrin on antioxidant enzymes and lipid peroxidation of Lake Van fish (Alburnus tarichi)

Cited by 23 publications

References 42 publications

Evaluation of the Impacts of Taurine on Oxidative Stress Indices in Sera and Brain of Rats Exposed to Cypermethrin

Evaluation of the Impacts of Taurine on Oxidative Stress Indices in Sera and Brain of Rats Exposed to Cypermethrin

Acute toxicity and impact of sublethal exposure to commonly used surfactants sodium dodecyl sulphate, cetylpyridinium chloride and sodium laureth sulphate on oxidative stress enzymes in oligochaete worm Branchiura sowerbyi (Beddard, 1892)

Combinations of cypermethrin and dimethoate alter behavior, hematology and histology of African Catfish, Clarias gariepinus

Contact Info

Product

Resources

About