Effects of CYP2C19 genetic polymorphism on the pharmacokinetics of tolperisone in healthy subjects

Cho, Chang‐Keun; Byeon, J.Y.; Kang, Pureum; Park, Hye-Jung; Ko, Eunvin; Mu, Chou Yen; Jang, Choon‐Gon; Lee, Seok-Yong; Lee, Yun Jeong

doi:10.1007/s12272-022-01423-0

Cited by 8 publications

(1 citation statement)

References 31 publications

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“…Moreover, the CYP2C19*17 allele (rs12248560, c.−806C > T) is a mutation present in the 5′-flanking region that increases gene transcription and CYP2C19 activity in vivo (Sim et al 2006). Pharmacokinetic changes caused by genetic polymorphism of the gene encoding the CYP2C19 enzyme have been reported for various drugs (Scott et al 2012;Choi et al 2014;Lee et al 2018;Cho et al 2023).…”

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confidence: 99%

Frequency of the *CYP2C19**10 Allele in the Korean Population

Hong

Bae

2023

DTT

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The CYP2C19 gene has a high proportion of poor metabolizers (PMs) in Asians, including Koreans, with the CYP2C19*2 and *3 alleles accounting for most of the PMs. CYP2C19*10 is a mutation that differs by 1 bp from CYP2C19*2 and cannot be distinguished by the conventional PCR-RFLP method using SmaI. Thus, the frequency of CYP2C19*10 may appear high in an ethnic group with a high frequency of CYP2C19*2. We classified CYP2C19*2 and *10 using the pyrosequencing method and carried out a study to accurately confirm their frequency. Four hundred and thirty-two healthy Korean subjects were studied. CYP2C19 alleles (CYP2C19*2, *3, *10, and *17) were detected using pyrosequencing assays. The allele frequencies observed here were 63.0% for CYP2C19*1, 26.4% for CYP2C19*2, 9.4% for CYP2C19*3, and 1.3% for CY-P2C19*17. The CYP2C19*10 allele was not detected. The frequencies of the CYP2C19 normal metabolizer, rapid metabolizer, intermediate metabolizer, and PM phenotypes were 40.0%, 1.6%, 45.1%, and 13.2%, respectively. Similar to previous studies, the frequencies of CYP2C19*2 and *3 were relatively high, and the frequency of CYP2C19*17 was low. Finally, in Koreans, the frequency of CYP2C19*10 seems to be extremely low.

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