This study was conducted to evaluate the toxic and harmful effects of Challenger insecticide compared to some plant extracts having insecticidal properties (Conyza aegyptiaca, Melia azedarach, and Vinca rosae) to control Agrotis ipsilon (Hüfn.) (Lepidoptera: Noctuidae). They could be used as alternatives, safer and effective products against many insect pests, also to prevent or minimize the chemical pesticide applications, consequently to keep away the environmental contamination.The alterations in the nutrient components and digestive enzyme activities in the haemolymph of Agrotis 6 th larval instar was determined after feeding the 5 th larval instar on castor bean leaves treated with tested plant extracts at 5 % concentration and Challenger insecticide at a concentration of 0.5 %. Feeding larvae on these insecticidal materials induced considerable reduction in the total protein, lipids, and carbohydrates, in larval haemolymph. Results recommend that tested insecticidal compounds at such low concentrations can hinder A. ipsilon larval duration, food consumed, and enzymatic possessions. So, the tested insecticidal materials could be applied as a control strategy for this pest.